Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycles: a prospective study

Ioannidis, George; Sacks, Gavin; Reddy, Nivedita; Seyani, Lata; Margara, R.; Lavery, Stuart; Trew, G.

doi:10.1093/humrep/deh644

Cited by 55 publications

(37 citation statements)

References 26 publications

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“…Progesterone is involved in endometrial maturation and high levels of this hormone allow for complete transformation of the endometrium [47]. Progesterone levels in the luteal phase are positively correlated with the chance of successful conception [48,49] and negatively correlated with uterine arterial pulsatility, which was found to be associated with recurrent pregnancy loss [50]. In women undergoing embryo transfer, live birth rates were greater for those receiving progesterone, compared with those who did not take progesterone [51].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E ( ApoE ) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

et al. 2015

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The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l 21 ) than women with genotypes without ApoE4 (120.49 pmol l 21 ), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.

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Section: Discussionmentioning

confidence: 99%

Apolipoprotein E ( ApoE ) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

et al. 2015

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“…They found that the single progesterone assay on day 14 postoocyte retrieval was significantly high in women with on-going pregnancies compared to women with an abnormal pregnancy. Ioannidis and colleagues concluded that single serum progesterone measurement could be a useful indicator of pregnancy outcome in women undergoing IVF/ICSI treatment (Ioannidis et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Abdelazim¹,

Belal²,

Makhlouf³

2013

J Turkish German Gynecol Assoc

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This study was designed to detect the relation between serum progesterone and viability of pregnancy during the first trimester. Prospective study carried out in Al-Rashid Maternity and Ahmadi Kuwait oil company hospitals, over three years from February 2009 to February 2012. Two hundred and Sixty (260) pregnant women were hospitalized due to vaginal bleeding and/or abdominal pain during the first trimester of their pregnancies and were included in this study. Women included in this study were; sure of dates, conceived spontaneously with no history of infertility and had a positive serum pregnancy test. 2 ml blood samples were taken for women included in this study for serum progesterone assay. Women included in this study were followed by ultrasound for the viability of the pregnancy till the end of first trimester and the outcome of their pregnancy were recorded, while women with exogenous progesterone support or multiple pregnancies or suspected ectopic pregnancy or Hydatiform mole were excluded from this study. Data were collected and statistically analyzed to detect the relationship between serum progesterone level and viability of pregnancy during the first trimester. The mean age of the studied population was 32.7 ± 5.1 years, the mean gestational age at progesterone assay was 9.7 ± 0.5 week and by the end of the first trimester, women included in this study were classified according to the viability of their pregnancies into; viable pregnancy group 178 (68.5%) cases and non-viable pregnancy group (ended by miscarriage) 82 (31.5%) cases. The mean serum progesterone of the studied population was significantly high in viable pregnancy group (46.5 ± 7.4 ng/ml) compared to non-viable pregnancy group (9.9 ± 4.8 ng/ml), (p <0.05). In this study; 6.7% of viable pregnancies had serum progesterone level <10 ng/ ml, while 20.7% of non-viable pregnancies had serum progesterone level >10 ng/ml, the serum progesterone at cut off level 10 ng/ml was 79.3% sensitive to diagnose non-viable pregnancy and was 93.3% specific to diagnose viable pregnancy. Also, in this study; 1.1% of viable pregnancies had serum progesterone level <20 ng/ ml, while 4.8% of non-viable pregnancies had serum progesterone level >20 ng/ml, the serum progesterone at cut off level 20 ng/ml was 95.1% sensitive to diagnose non-viable pregnancy and was 98.9% specific to diagnose viable pregnancy. Serum progesterone is a reliable marker for early pregnancy failure and single assay of its serum level can differentiate between viable and non-viable pregnancies.

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“…No correlation between increased mid-luteal serum P levels and high pregnancy rate in women undergoing COH was observed. In contrast, Ioannidis et al (16) have suggested that mid-luteal serum P measurement may be a useful indicator of pregnancy, with high sensitivity and specificity. Some investigators have reported higher preimplantation levels of P in pregnant women, whereas lower levels were found to be associated with abnormal pregnancies (17)(18)(19).…”

mentioning

confidence: 94%

Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection

Ganesh

Goswami

Chattopadhyay

et al. 2009

Fertility and Sterility

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Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycles: a prospective study

Cited by 55 publications

References 26 publications

Apolipoprotein E ( ApoE ) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

Apolipoprotein E ( ApoE ) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

Relation between single serum progesterone assay and viability of the first trimester pregnancy

Luteal phase estradiol level: a potential predictive marker for successful pregnancy in in vitro fertilization/intracytoplasmic sperm injection

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