Day-night variation in prepro vasoactive intestinal peptide/peptide histidine isoleucine mRNA within the rat suprachiasmatic nucleus

Albers, H. Elliott; Stopa, Edward G.; Zoeller, R. Thomas; Kauer, John S.; King, Joan C.; Fink, J. Stephen; Mobtaker, H.; Wolfe, Hubert J.

doi:10.1016/0169-328x(90)90077-q

Cited by 125 publications

(44 citation statements)

References 21 publications

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“…The content of VIP and its mRNA is known to display diurnal variation in a light-responsive manner (Takahashi et al 1989;Albers et al 1990;Okamoto et al 1991). Combined application of VIP, PHI, and GRP induces a phase shift of locomotor activity rhythm and a change in electrical activity (Albers et al 1991).…”

Section: Discussionmentioning

confidence: 99%

“…dial part showed a light-independent endogenous rhythm (Schwartz et al 1983;Uhl and Reppert 1986), and VIP in the ventrolateral part showed light-dependent changes (Takahashi et al 1989;Albers et al 1990;Okamoto et al 1991). Somatostatin (SS) expression in neurons located in the bordering region of ventrolateral and dorsomedial components shows a light-independent endogenous rhythm (Fukuhara et al 1993;Nishiwaki et al 1995).…”

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confidence: 99%

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Peptide Expression in GABAergic Neurons in Rat Suprachiasmatic Nucleus in Comparison with Other Forebrain Structures: A Double Labeling In Situ Hybridization Study

Tanaka

Matsuda

Shigeyoshi

et al. 1997

J Histochem Cytochem.

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SUMMARYWe investigated the characteristics of GABAergic neurons in the rat suprachiasmatic nucleus (SCN) in normal untreated rats by examination of co-expressed peptides. We adopted double labeling in situ hybridization using a digoxigenin-labeled glutamic acid decarboxylase (GAD) riboprobe and 35 S-labeled peptide riboprobes. GAD mRNA-positive neurons were distributed throughout the SCN from the rostral to the caudal pole. In the dorsomedial part of the SCN, most GAD mRNA-positive neurons co-expressed arginine vasopressin mRNA. In the ventrolateral part of the SCN, about two thirds of GAD mRNApositive neurons co-expressed vasoactive intestinal peptide (VIP) mRNA. Co-expression of GAD and somatostatin mRNA was observed in virtually all neurons of the intermediate part of the SCN. In contrast, these peptidergic traits were poorly expressed in hypothalamic GABAergic neurons outside the SCN. Vasopressin mRNA-positive cells in the supraoptic nucleus did not express GAD mRNA, and co-expression of somatostatin mRNA and GAD mRNA was rare in the periventricular hypothalamic nucleus. Similarly, the VIP mRNA co-expression ratio of GABAergic neurons in the cerebral cortex was far lower than that in the SCN.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Peptide Expression in GABAergic Neurons in Rat Suprachiasmatic Nucleus in Comparison with Other Forebrain Structures: A Double Labeling In Situ Hybridization Study

Tanaka

Matsuda

Shigeyoshi

et al. 1997

J Histochem Cytochem.

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“…VP-LIR neuronal processes were mainly distributed in the dorsomedial portion of the SCN and were intermingled with the VP-LIR neuronal perikarya. It has been clarified that VIP-like immunoreactivity and mRNA of VIP-LIR substance show diurnal variation under the influence of light from the retina [1,5,21,25] and mRNA of VP-LIR substance show circadian rhythm without the influence of light in the rat SCN [28]. Therefore it is prerequisite to scrutinize whether or not similar phenomena occur in the VIP-LIR and VP-LIR neurons in the monkey SCN.…”

Section: Distribution Of Vip-lir and Vp-lir Neuronal Elementsmentioning

confidence: 99%

“…These inputs make synaptic contacts with the VIP-LIR neuronal elements [6,9,14,26]. Moreover, it has been demonstrated that VIP-LIR neurons show a diurnal variation in their immunoreactivity [25] and messenger RNA (mRNA) [1,5,21], and that this variation appears to be under the influence of the neuronal inputs from the retina. Therefore we considered the VIP-LIR neurons to play a significant role in entrainment.…”

Section: Introductionmentioning

confidence: 99%

VIP-like Immunoreactive and Vasopressin-like Immunoreactive Neuronal Elements in the Suprachiasmatic Nucleus of Japanese Monkey (Macaca fuscata): Light and Electron Microscopic Immunocytochemical Study

Ibata

Tanaka

Iijima

et al. 2003

Acta Histochem. Cytochem

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VIP-like immunoreactive (VIP-LIR) and vasopressin-like immunoreactive (VP-LIR) neuronal elements located in the monkey suprachiasmatic nucleus (SCN) were investigated by light and electron microscopic immunocytochemistry. Both populations of neurons in the monkey SCN show a similar distribution to those of the rat except for some subtle differences. In addition to the ordinary distribution of VIP-LIR and VP-LIR neurons, VIP-LIR neurons of similar or some smaller size to those in the ventrolateral portion of the nucleus were also observed in the periventricular nucleus adjacent to the third ventricle. VP-LIR neurons with similar size and either strong or weak immunoreactivity compared with those located in the dorsomedial area were detected in the periventricular nucleus in which magnocellular VP-LIR neurons with strong immunoreactivity were distributed. Both VIP-LIR and VP-LIR neuronal perikarya were found to contain well developed cell organelles such as rER and mitochondria as well as immunoreactive dense granules. VIP-LIR neuronal perikarya were generally surrounded by astroglial processes. However, nonimmunoreactive axons were frequently found to make synaptic contact with VIP-LIR dendrites or dendritic spines. Thus the VIP-LIR neurons are thought to receive neuronal inputs from other parts of CNS mainly from the dendrites or dendritic spines. VIP-LIR and VP-LIR axons were seen to form synapses on non-immunoreactive dendrites. VIP-LIR axons were also found to form axoaxonic synapses on non-immunoreactive axons. Synaptic contacts between VIP-LIR neuronal elements were also occasionally observed. The present study has demonstrated that both the VIP-LIR and VP-LIR neurons are at least partly intrinsic neurons in the SCN, and also projecting elements to the other neurons of the CNS.

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“…PHI, VIP, peptide histidine valine (PHV), and peptide histidine methionine, among others, are processed from this precursor molecule. Prepro-VIPrelated peptides, including PHI, share a structural homology, as well as a certain degree of functional similarities, e.g., by having a stimulatory effect on the release and/or synthesis of glucagon (8), prolactin (20,28,40), and melatonin (21,37,49), and by affecting circadian rhythmicity (2,3), heart rate (38), vasomotor functions (15,19), and activation of the hypothalamic-pituitaryadrenal (HPA) axis (4,6).…”

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confidence: 99%

Effect of peptide histidine isoleucine on consummatory behavior in rats

Olszewski

Wirth

Shaw

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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. Effect of peptide histidine isoleucine on consummatory behavior in rats. Am J Physiol Regul Integr Comp Physiol 284: R1445-R1453, 2003. First published February 20, 2003 10.1152/ajpregu.00554.2002-Peptide histidine isoleucine (PHI) and VIP are derived from the same precursor. While central VIP decreases food intake, potential effects of PHI on feeding have not been studied. In the current study, we found that PHI administered intracerebroventricularly (ICV) or into the hypothalamic paraventricular nucleus (PVN) or central nucleus of the amygdala (CeA) decreased food consumption in overnight-deprived rats. The magnitude of an anorexigenic response to PHI differed depending on the injection route: ICV-infused peptide evoked the most potent effect. We determined that that only PVN-and CeA-injected PHI did not have aversive consequences. In addition, we infused anorexigenic doses of PHI via the same routes and assessed Fos immunoreactivity of PVN oxytocin (OT) and vasopressin (VP) neurons using double immunohistochemistry. OT and VP are thought to promote feeding termination. PHI increased the percentage of Fos-positive OT neurons regardless of the injection route. PVN-and ICV-infused PHI induced activation of VP cells. We conclude that central PHI has an inhibitory influence on food intake in rats. The PVN, with OT and VP neurons, and CeA may be involved in the mediation of anorexigenic effects of PHI. conditioned taste aversion; oxytocin; vasopressin; paraventricular nucleus of the hypothalamus; amygdala PEPTIDE HISTIDINE ISOLEUCINE (PHI) belongs to the pituitary adenylate cyclase-activating polypeptide (PACAP)/ glucagon family derived from a common precursor protein, prepro-VIP. PHI, VIP, peptide histidine valine (PHV), and peptide histidine methionine, among others, are processed from this precursor molecule. Prepro-VIPrelated peptides, including PHI, share a structural homology, as well as a certain degree of functional similarities, e.g., by having a stimulatory effect on the release and/or synthesis of glucagon (8), prolactin (20,28,40), and melatonin (21, 37, 49), and by affecting circadian rhythmicity (2, 3), heart rate (38), vasomotor functions (15, 19), and activation of the hypothalamic-pituitaryadrenal (HPA) axis (4, 6).PHI is widespread throughout the central and peripheral nervous systems (12). The presence of this peptide has been demonstrated in numerous central regions, where PHI often colocalizes in neurons with other products of prepro-VIP (13). Interestingly, PHIcontaining neuronal elements are encompassed in several brain sites involved in the regulation of consummatory behavior, including the hypothalamic paraventricular (PVN), supraoptic (SON), and arcuate (ARC) nuclei, central nucleus of the amygdala (CeA), and bed nucleus of the stria terminalis (17, 30).The abundance of receptors for PHI in these feedingrelated areas has also been confirmed. There are two well-described subtypes of receptors for PHI, termed VIP1 and VIP2 (18,24,45). These receptors do not seem to be selective to PHI al...

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Day-night variation in prepro vasoactive intestinal peptide/peptide histidine isoleucine mRNA within the rat suprachiasmatic nucleus

Cited by 125 publications

References 21 publications

Peptide Expression in GABAergic Neurons in Rat Suprachiasmatic Nucleus in Comparison with Other Forebrain Structures: A Double Labeling In Situ Hybridization Study

Peptide Expression in GABAergic Neurons in Rat Suprachiasmatic Nucleus in Comparison with Other Forebrain Structures: A Double Labeling In Situ Hybridization Study

VIP-like Immunoreactive and Vasopressin-like Immunoreactive Neuronal Elements in the Suprachiasmatic Nucleus of Japanese Monkey (Macaca fuscata): Light and Electron Microscopic Immunocytochemical Study

Effect of peptide histidine isoleucine on consummatory behavior in rats

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