DBS are suitable for 1,5-anhydroglucitol monitoring in GSD1b and G6PC3-deficient patients taking SGLT2 inhibitors to treat neutropenia

Dewulf, Joseph P.; Chevalier, Nathalie; Marie, Sandrine; Veiga-da-Cunha, Maria

doi:10.1016/j.ymgme.2023.107712

Cited by 2 publications

(1 citation statement)

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“…Almost all 1,5-AG excreted in urine is reabsorbed in the renal tubules by specific sodium-glucose cotransporter 4 or specific sodium-glucose cotransporter 5 (SGLT4 or SGLT5), and this process ( 4 ) is competitively inhibited by glucose since 1,5-AG and glucose share the transporter protein ( Figure 2 ). Previous research had suggested that SGLT4 is the renal transporter for 1,5-AG, but more recently it has been demonstrated that 1,5-AG is transported by SGLT5, while mannose is transformed by SGTL4 ( 5 , 6 ). Nevertheless, there could be some optional bias because these studies are focused on patients with neutropenia.…”

Section: Overview Of 15-agmentioning

confidence: 99%

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

Xu,

Pan,

Chen

2024

Front. Endocrinol.

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1,5-Anhydroglucitol (1,5-AG) is sensitive to short-term glucose fluctuations and postprandial hyperglycemia, which has great potential in the clinical application of diabetes as a nontraditional blood glucose monitoring indicator. A large number of studies have found that 1,5-AG can be used to screen for diabetes, manage diabetes, and predict the perils of diabetes complications (diabetic nephropathy, diabetic cardiovascular disease, diabetic retinopathy, diabetic pregnancy complications, diabetic peripheral neuropathy, etc.). Additionally, 1,5-AG and β cells are also associated with each other. As a noninvasive blood glucose monitoring indicator, salivary 1,5-AG has much more benefit for clinical application; however, it cannot be ignored that its detection methods are not perfect. Thus, a considerable stack of research is still needed to establish an accurate and simple enzyme assay for the detection of salivary 1,5-AG. More clinical studies will also be required in the future to confirm the normal reference range of 1,5-AG and its role in diabetes complications to further enhance the blood glucose monitoring system for diabetes.

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Section: Overview Of 15-agmentioning

confidence: 99%