DC Calcium lactate, a new filler-binder for direct compaction of tablets

Bolhuis, G.K.; Eissens, Anko C.; Zoestbergen, E

doi:10.1016/s0378-5173(01)00657-3

“…Bolhuis et al (2001) compared the compaction properties of diOE erent hydrates of calcium lactate. Calcium lactate pentahydrate was found to have low strain-rate sensitivity and a high bonding capacity, indicating its suitability as a ® ller in direct compression formulations.…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

Hardy

¹

,

Cook

²

2003

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster development and manufacture of dosage forms. A variety of approaches to prediction or correlation of properties are reviewed. These approaches have variable accuracy, with no single technique yet able to provide an accurate prediction of the overall properties of the dosage form. However, there have been some successes in predicting trends within a formulation series based on the physicochemical and mechanical properties of raw materials, predicting process scale-up through mechanical characterisation of materials and predicting product characteristics by process monitoring. Advances in information technology have increased predictive capability and accuracy by facilitating the analysis of complex multivariate data, mapping formulation characteristics and capturing past knowledge and experience.

show abstract

“…Compaction simulators may also be used to study the mechanical properties of excipients. Bolhuis et al (2001) compared the compaction properties of diOE erent hydrates of calcium lactate. Calcium lactate pentahydrate was found to have low strain-rate sensitivity and a high bonding capacity, indicating its suitability as a ® ller in direct compression formulations.…”

Section: Mechanical Properties Of the Bulk Materialsmentioning

confidence: 99%

In-vitro evaluation of bioadhesion in particulate systems and possible improvement using interactive mixtures

Bredenberg

¹

,

Nyström

²

2003

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

There is much interest in predicting the properties of pharmaceutical dosage forms from the properties of the raw materials they contain. Achieving this with reasonable accuracy would aid the faster development and manufacture of dosage forms. A variety of approaches to prediction or correlation of properties are reviewed. These approaches have variable accuracy, with no single technique yet able to provide an accurate prediction of the overall properties of the dosage form. However, there have been some successes in predicting trends within a formulation series based on the physicochemical and mechanical properties of raw materials, predicting process scale-up through mechanical characterisation of materials and predicting product characteristics by process monitoring. Advances in information technology have increased predictive capability and accuracy by facilitating the analysis of complex multivariate data, mapping formulation characteristics and capturing past knowledge and experience.

show abstract

“…Though several filler-binders are available in the market, efforts to find more compressible filler-binders or that have multifunctions, persist [2][3][4]. For examples, a free-flowing form of calcium lactate pentahydrate has been found to be an effective filler-binder for direct compression [2].…”

Section: Introductionmentioning

confidence: 99%

“…For examples, a free-flowing form of calcium lactate pentahydrate has been found to be an effective filler-binder for direct compression [2]. Kumar and Medina developed and evaluated novel cellulose II powders as multifunctional filler-binders in the formulation of direct compression tablets [3,4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Weakly Cationic Exchange Poly (Methacrylic Acid-Co-Divinylbenzene) Resin as Filler- Binder for Direct Compression Tablets

Akkaramongkolporn

¹

,

Ngawhirunpat²,

Opanasopit³

2012

Trop. J. Pharm Res

1

0

View full text Add to dashboard Cite

Purpose: To evaluate a weakly cationic exchange poly(methacrylic acid-co-divinylbenzene) resin (PMD) as a new filler-binder for direct compression tablets. Methods: Powder properties of PMD and MCC were characterized. Tablets made from PMD and MCC with and without propranolol hydrochloride were evaluated for diameter, thickness, friability, assay, disintegration, dissolution and compression behavior. Results: Tablets made from PMD (thickness: 3.54 -4.46 mm) were thicker than those of MCC (2.93 -3.33 mm). At compression pressures ≥ 309 MPa, the crushing strength of PMD tablets was so high that it exceeded the capacity of the tester (500 N). PMD tablets rapidly disintegrated (0.43 -9.56 min), but MCC tablets did not disintegrate within 60 min. The crushing strength of PMD tablets containing 10 and 100 mg propranolol hydrochloride was 406.1 and 177.9 N, respectively, which were lower than that of tablets without the drug. Tablets made from PMD also exhibited faster drug dissolution. The slopes of the linear portions of Heckel plots for PMD and MCC were comparable (5.02×10 -3 and 5.12×10 -3 MPa -1 ), respectively. Conclusion: PMD has good compressibility at high compression pressures, which should make it a suitable filler-binder for direct compression tablets.

show abstract

DC Calcium lactate, a new filler-binder for direct compaction of tablets

Cited by 21 publications

References 8 publications

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms

In-vitro evaluation of bioadhesion in particulate systems and possible improvement using interactive mixtures

Evaluation of a Weakly Cationic Exchange Poly (Methacrylic Acid-Co-Divinylbenzene) Resin as Filler- Binder for Direct Compression Tablets

Contact Info

Product

Resources

About