DC discharges in atmospheric air for bio-decontamination – spectroscopic methods for mechanism identification

Machala, Zdenko; Jedlovský, I.; Chladekova, Lenka; Pongrác, Branislav; Giertl, D.; Janda, M.; Šikurová, L; Polčic, Peter

doi:10.1140/epjd/e2009-00035-7

Cited by 61 publications

(40 citation statements)

References 30 publications

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“…Studies using isolated protein and plasmid DNA models have shown protein and DNA damages [95]- [99], and more relevant experiments using bacterial cells have provided direct evidence of breaching and rapture of cell membrane [100], reduction and degradation of proteins [101]- [103], lipid damage [104], and (mostly) single-strand breaks (SSB) of DNA [105]. These results have prompted the suggestion of the involvement of ROS, charged particles, and UV photons [92][100] [105] - [108], with ROS often linked to oxidation of protein and lipid and with UV photons linked to DNA damages.…”

Section: Reactive Plasma Species and Their Biological Targetsmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

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To cite this version:M G Kong, M Keidar, K Ostrikov. Plasmas meet nanoparticleswhere synergies can advance the frontier of medicine. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (17) AbstractNanoparticles and low-temperature plasmas have been developed, independently and often along different routes, to tackle the same set of challenges in biomedicine. There are intriguing similarities and contrasts in their interactions with cells and living tissues, and these are reflected directly in the characteristics and scope of their intended therapeutic solutions, in particular their chemical reactivity, selectivity against pathogens and cancer cells, safety to healthy cells and tissues, and targeted delivery to diseased tissues. Time has come to ask the inevitable question of possible plasma-nanoparticle synergy and the related benefits to the development of effective, selective, and safe therapies for modern medicine. This perspective article offers a detailed review of the strengths and weakenesses of nanomedicine and plasma medicine as a stand-alone technology, and then provides a critical analysis of some of the major opportunities enabled by synergising the nanotechnology and the plasma technology. It is shown that the plasma-nanoparticle synergy is best captured through the plasma nanotechnology and its benefits for medicine are highly promising.

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Section: Reactive Plasma Species and Their Biological Targetsmentioning

confidence: 99%

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

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“…Nevertheless, the measurement of TBARS by referring to MDA provides an indicator of the peroxidation of membrane lipids because of the interaction of ROS with the cell membrane. For plasma-liquid systems, MDA was positively analyzed during the decontamination of water containing Salmonella typhimurium, Bacillus cereus, and Saccharomyces cerevisiae using water electrospray direct current (DC) discharge and E. coli using DBD, demonstrating the occurrence of this inactivation route in gas-liquid plasmas [10,15,16,32].…”

Section: Introductionmentioning

confidence: 99%

Membrane damage and active but nonculturable state in liquid cultures of Escherichia coli treated with an atmospheric pressure plasma jet

Doležalová

Lukeš

2015

Bioelectrochemistry

163

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“…However, in the case of more intensive transient spark discharges in atmospheric air, the OH emission line at 308.9 nm was clearly detected, which indicates that such non-thermal plasma discharges are capable of generating a significant concentration of OH radicals in gaseous medium [10]. As indicated in [11], the concentration of OH radicals in non-thermal plasma can be 10 13 -10 15 cm -3 .…”

Section: Introductionmentioning

confidence: 94%

“…Transient atmospheric plasma discharges have been selected for this study due to their high bioinactivation capability: it has been shown in [10] that such transient sparks demonstrate a higher bactericidal efficiency as compared with corona discharges. In the present paper, the efficiency of OH production in water-based solutions by the transient plasma discharges was obtained as a function of peak voltage level, polarity, total delivered charge, and discharge propagation path.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence detection of hydroxyl radicals in water produced by atmospheric pulsed discharges

Timoshkin

Maclean

et al. 2015

IEEE Trans. Dielect. Electr. Insul.

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It has been proven that hydroxyl (OH) radicals can be generated by streamer discharges across water surfaces under ambient atmospheric conditions. Hydroxyl radicals have the highest oxidation capability amongst all oxygen-based reactive species, thus OH play an important role in oxidation of organic molecules and the bactericidal effects of plasma discharges. In this study, generation of hydroxyl radicals in water by pulsed streamer discharges was investigated. Terephthalic acid was used as a chemical probe as this acid is converted into 2-hydroxyterephthalic acid (HTA) by chemical reaction with OH radicals. The concentration of OH radicals was quantified by measuring the fluorescence light intensity generated by HTA molecules in water solutions. Both positive and negative pulsed discharges with different voltage levels were tested. Two different types of sample holder -non-conductive plastic dishes, and dishes lined with conductive aluminum foilwere used in order to investigate the effect of the discharge propagation path on the efficiency of OH production. The efficiency of OH production was measured as a function of: the distance between the needle electrode and the water surface; the magnitude and polarity of HV energization; and the total delivered charge. The obtained results will help in optimization of non-thermal plasma systems for chemical and biological decontamination.

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DC discharges in atmospheric air for bio-decontamination – spectroscopic methods for mechanism identification

Cited by 61 publications

References 30 publications

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Membrane damage and active but nonculturable state in liquid cultures of Escherichia coli treated with an atmospheric pressure plasma jet

Fluorescence detection of hydroxyl radicals in water produced by atmospheric pulsed discharges

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