Smart grid implementation is facilitated by multi-source energy systems development, i.e., microgrids, which are considered the key smart grid building blocks. Whether they are alternative current (AC) or direct current (DC), high voltage or low voltage, high power or small power, integrated into the distribution system or the transmission network, multi-source systems always require an intelligent energy management that is integrated into the power system. A comprehensive intelligent energy system aims at providing overall energy efficiency with regard to the following: increased power generation flexibility, increased renewable generation systems, improved energy consumption, reduced CO2 emission, improved stability, and minimized energy cost. This Special Issue presents recent key theoretical and practical developments that concern the models, technologies, and flexible solutions to facilitate the following optimal energy and power flow strategies: the techno-economic model for optimal sources dispatching (mono and multi-objective energy optimization), real-time optimal scheduling, and real time optimization with model predictive control.