2018
DOI: 10.21873/invivo.11247
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DCLK1 Expression in Colorectal Polyps Increases with the Severity of Dysplasia

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Cited by 7 publications
(10 citation statements)
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“…Recent studies showed that the inflammatory process may also lead to induction of colorectal tumorigenesis with secondary increase of DCLK1 at the cellular level (17)(18)(19). In the early stage of CRC carcinogenesis, the expression of DCLK1 seems to increase from low-grade adenomas with worsening severity of dysplasia (18,19).…”
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confidence: 99%
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“…Recent studies showed that the inflammatory process may also lead to induction of colorectal tumorigenesis with secondary increase of DCLK1 at the cellular level (17)(18)(19). In the early stage of CRC carcinogenesis, the expression of DCLK1 seems to increase from low-grade adenomas with worsening severity of dysplasia (18,19).…”
mentioning
confidence: 99%
“…Recent studies showed that the inflammatory process may also lead to induction of colorectal tumorigenesis with secondary increase of DCLK1 at the cellular level (17)(18)(19). In the early stage of CRC carcinogenesis, the expression of DCLK1 seems to increase from low-grade adenomas with worsening severity of dysplasia (18,19). Moreover, significantly higher DCLK1 expression levels were detected in CRC tissue than in normal colonic specimens, and DCLK1 silencing significantly inhibited cell migration, invasion, and sphere-forming potential (20).…”
mentioning
confidence: 99%
“…The expression of intestinal stem cell markers Sox9, Hopx, and survivin as well as tuft cell marker DCLK1 is of high interest in human colorectal cancer regarding prognosis and as possible therapeutic targets. 1,10,14,15,32,34,43,49 51,53,56,58,76,79,82 Shared molecular characteristics in human and canine sporadic CRCs, such as frequent mutations of adenomatous polyposis coli gene, suggest sporadic canine CRCs as an appropriate model for human disease. 88…”
Section: Discussionmentioning
confidence: 99%
“…Initial assumptions interpreted these cells as quiescent stem cells that might play a role as CSCs. 12 14,21 23,58,76,83 Although more recent studies identified the DCLK1 + cell population within the intestinal epithelium as tuft cells, 25 DCLK1 is still of interest in gastrointestinal oncology. Nakanishi et al 64 have shown DCLK1 to discriminate between normal IESCs and CSCs.…”
Section: Discussionmentioning
confidence: 99%
“…DCLK1 can act as an intestinal CSC marker and is a potential target for novel therapies in CRC [ 51 ]. As for MACC1, DCLK1 increases in CRC during the transition from early-stage adenoma to more advanced dysplasia [ 52 ]. Mohammadi et al have shown the regulation of DCLK1 by miR-200.…”
Section: Discussionmentioning
confidence: 99%