De novo cerebellar medulloblastoma in a 26-year recurrence-free case of temporal glioblastoma multiforme

Abstract

<jats:p>The authors describe a patient who survived 26 years after resection of a right temporal glioblastoma multiforme (GBM) without signs of tumor recurrence. Preoperative emergency angiography demonstrated a hypovascular mass localized in the right temporal lobe with right-to-left shift of the vascular structures. At surgery, the tumor had cystic and solid components localized in the lateral occipitotemporal gyrus, reaching the posterolateral wall of the inferior horn of the right lateral ventricle and extending to the trigone and posterior horn. The initial pathological diagnosis of a GBM was reviewed and confirmed throughout the follow-up period. Twenty-six years after surgery and subsequent radiosurgery, the patient underwent resection of a medulloblastoma localized in the right cerebellum as well as stereotactic biopsy sampling of tissue at the original GBM site. Neither radiological nor histological evidence of recurrence of the GBM could be documented. The intraoperative, histological, and radiological findings are described.</jats:p>

Medulloblastomas – Primitive neuroectodermal tumours in the adult population

“…16 There are, however, case reports of this malignancy occurring after previous radiotherapy. 17,18 There was no association in this group, nor has it occurred in any other patient in this department irradiated for a CNS tumour.…”