Deafness Due to Orally Administered Neomycin

Gibson, William S

doi:10.1001/archotol.1967.00760050165008

Cited by 19 publications

(6 citation statements)

References 7 publications

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“…Hear ing loss is one of the most serious potential toxic effects of neomycin ther apy [8,11,16,20]. The range of plasma neomycin concentrations associ ated with ototoxicity in adults is poorly defined [2,5,18].…”

Section: Discussionmentioning

confidence: 99%

“…Neomycin is a potentially toxic drug which, like other aminoglycoside antibiotics, can cause deafness and kidney damage [8,11,20], In adults, neomycin is poorly absorbed from the gastrointestinal tract [5,17,23] but the extent of its absorption in infants with gastrointes tinal disease is unknown. The purpose of this communication is to report the oral absorption of neomycin in 2 premature infants with NEC.…”

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confidence: 99%

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Absorption of Oral Neomycin in Premature Infants with Suspected Necrotizing Enterocolitis

Nation¹,

Huang²,

Vidyasagar³

et al. 1982

Dev Pharmacol Ther

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The oral absorption of neomycin was studied in 2 premature infants (32 weeks of gestation) with suspected necrotizing enterocolitis. 1 infant received 50 mg and the other 100 mg of neomycin sulfate/kg/day in 4 divided doses for approximately 7 days. Plasma neomycin levels were determined by a micro, sensitive and specific high-performance liquid chromatographic assay developed in our laboratory. Plasma levels as high as 2.9 and 4.5 μg/ml were observed in these 2 infants. A urinary recovery study for 1 infant revealed that at least 3.7% of the oral dose was absorbed. The significant and persistent plasma levels of neomycin in these patients suggest the need for extreme caution in using this potentially toxic antibiotic for prolonged treatment in neonates.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Absorption of Oral Neomycin in Premature Infants with Suspected Necrotizing Enterocolitis

Nation¹,

Huang²,

Vidyasagar³

et al. 1982

Dev Pharmacol Ther

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show abstract

“…Despite these properties, which are particularly useful in treating type Ila, the compound has not achieved widespread use. This could be related to its major side effect of audio toxicity (Gibson, 1967;Greenwood, 1959;Halpern and Heller, 1961;Greenberg and Momary, 1965;King, 1962). Neomycin, if absorbed in quantity, can cause permanent deafness with oral treatment (several cases have been reported).…”

Section: D-thyroxinementioning

confidence: 99%

Hypolipaemic drugs and coronary heart disease

Howard¹

1975

Journal of Clinical Pathology

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“…The toxic effect of aminoglycoside antibiotics on the inner ear has been known for a long time, not only after parenteral but also after oral or intra-articular administration (Ballantyne, 1983;Brummett, 1980;Engstrom and Kohonen, 1965;Gibson, 1967;Gonzalez and Ona, 1975). Topical applications have also caused lesions when these antibiotics were given intrabronchially by aerosols (Fuller, 1960) or as a wound irrigant (Kelly et al, 1969).…”

Section: Introductionmentioning

confidence: 99%

Long-term ototoxic effects of neomycin applied topically in the middle ear: A morphological study in the guinea pig

Moráis

González

et al. 1988

J. Laryngol. Otol.

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Neomycin was instilled daily, uni-or bilaterally, into the middle ear of guinea pigs for three months. The cochleae were examined, by light and electron microscopy, six months after the end of treatment. The organs of Corti of the treated ears were completely destroyed, and in the most advanced lesions, were substituted by a single layer of very thin flat cells. In the spiral ganglion only some glial cells and a few neurons could be observed. All surviving neurons were myelinated, and their ultrastructure was greatly altered, with disappeared, losing it amorphous and filamentous components. The spiral limbus and the stria vascularis were atrophic and were also covered, in the final stages, by flat elongated cells. In view of its morphological characteristics, this epithelium may arise from the displacement of the interdental cells and perhaps from the cochlear surface of Reissner's membrane.

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Deafness Due to Orally Administered Neomycin

Cited by 19 publications

References 7 publications

Absorption of Oral Neomycin in Premature Infants with Suspected Necrotizing Enterocolitis

Absorption of Oral Neomycin in Premature Infants with Suspected Necrotizing Enterocolitis

Hypolipaemic drugs and coronary heart disease

Long-term ototoxic effects of neomycin applied topically in the middle ear: A morphological study in the guinea pig

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