Dealing with the hidden unphysical constraint and the butterfly effect in spectrum computations

Zhang, Yi; Sun, Weiguo; Fu, Jia; Fan, Qunchao; Ma, Jie; Liu, Xiao; Jia, Suotang; Feng, Hao; Li, Huidong

doi:10.1016/j.jqsrt.2013.02.018

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…Moreover, mitochondrion is a key power house of most cells, so it is with cancer cells as well [ 15 ]. There have been a vast body of studies involving mitochondria that would commence compensating for the insufficient energy of in harsh conditions of cancer cells through the tricarboxylic acid cycle (TCA) and oxidative phosphorylation [ 16 – 19 ]. Questions have been raised about the impact of mitochondria which might remedy the energy deprivation of starvation therapy [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Boosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO

Wang

Fan

et al. 2022

J Nanobiotechnol

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Background By hindering energy supply pathway for cancer cells, an alternative therapeutic strategy modality is put forward: tumor starvation therapy. And yet only in this blockade of glucose supply which is far from enough to result in sheer apoptosis of cancer cells. Results In an effort to boost nutrient starvation-dominated cancer therapy, here a novel mitochondrial Ca2+ modulator Alg@CaP were tailor-made for the immobilization of Glucose oxidase for depriving the intra-tumoral glucose, followed by the loading of Curcumin to augment mitochondrial Ca2+ overload to maximize the therapeutic efficiency of cancer starvation therapy via mitochondrial dysfunctions. Also, autophagy inhibitors Obatoclax were synchronously incorporated in this nano-modulator to highlight autophagy inhibition. Conclusion Here, a promising complementary modality for the trebling additive efficacy of starvation therapy was described for cutting off the existing energy sources in starvation therapy through Curcumin-augmented mitochondrial Ca2+ overload and Obatoclax-mediated autophagy inhibition. Graphical Abstract

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