Death by SARS-CoV 2: a Romanian COVID-19 multi-centre comorbidity study

Stoian, Anca Pantea; Pricop-Jeckstadt, Mihaela; Pană, Adrian; Ileanu, Bogdan Vasile; Schitea, Ruxandra-Ioana; Geantă, Marius; Catrinoiu, Doina; Suceveanu, Andra Iulia; Serafinceanu, Cristian; Pițuru, Silviu; Poiană, Cătălina; Timar, Bogdan; Nițipir, Cornelia; Pârvu, Simona; Arsene, Andreea Letiția; Mazilu, Laura; Toma, Antonela; Hainăroşie, Răzvan; Ceriello, Antonio; Rizzo, Manfredi; Jinga, Viorel

doi:10.1038/s41598-020-78575-w

Cited by 54 publications

(43 citation statements)

References 30 publications

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“…Among the first 147 COVID-19 cases in Romania, 88 were imported cases, with 64 from Italy [12]. At the first release of the present survey, there were around 9000 cases, more than 40,000 people quarantined at home, and more than 500 deaths from COVID-19 [14]. Even if many distancing rules were maintained for almost the entire year, including schools closing [15], the social pressure made it impossible and unreasonable to reimpose strict measures as in the beginning of the pandemic.…”

Section: Perspectives On Covid-19 Prevention and Knowledgementioning

confidence: 65%

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Perceptions of Romanian Physicians on Lockdowns for COVID-19 Prevention

Dima

Balaban

Jurcuţ³

et al. 2021

Healthcare

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) was declared a pandemic in March 2020, triggering important changes for the entire society and healthcare systems, as well as significant lockdown measures aimed to limit the disease spread. We herein intended to catch the dynamic of Romanian physicians’ perceptions of COVID-19 impact. For this purpose, after a literature review, a 30-item questionnaire was designed. The questionnaire was twice distributed online, about 1 month apart, during which partial relaxation measures were decreed in Romania. The questionnaire was voluntarily filled in by Romanian physicians who were willing to participate in the study. A total of 214 physicians answered the questionnaire upon its first release, and 199 respondents were registered upon its second release, most of whom (94.9%) were involved in clinical work, with one-third working in units dedicated to COVID-19 patients. In parallel with the relaxation of lockdown measures, along with increased confidence in the efficiency of protective measures (46.7% vs. 31.3%), separation from household members decreased from 36.9% to 22.1%. Nevertheless, the feeling of rejection felt by doctors remained similar (22.4% vs. 24.6%). Furthermore, answers regarding the clinical picture, diagnostic approach, and treatment options are discussed. Most of therapeutic options considered for SARS-CoV-2 treatment (e.g., lopinavir/ritonavir, oseltamivir, hydroxychloroquine, azithromycin, tocilizumab, and convalescent plasma) failed to confirm significant efficiency. On the contrary, vaccines for widescale use are already available despite the initial skepticism. In the beginning of the pandemic, 25.2% (18.2% vs. 32.2%) considered that there will not be an effective COVID-19 vaccine, while 41.6% (43.0% vs. 40.2%) thought that a vaccine would be available after at least 12 months. In conclusion, initially, following only a 1 month period, Romanian physicians’ intention to consider treatments such as hydroxychloroquine or lopinavir/ritonavir for COVID-19 decreased significantly. Moreover, confidence in the efficiency of available protective measures increased, and the rates of separation from household members decreased.

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Section: Perspectives On Covid-19 Prevention and Knowledgementioning

confidence: 65%

“…In Romania, the first case of SARS-CoV-2 infection was confirmed on 26 February 2020, a contact of an Italian citizen [13], and, 1 month later, on 22 March 2020, the first COVID-19 death was noted [14]. Among the first 147 COVID-19 cases in Romania, 88 were imported cases, with 64 from Italy [12].…”

Section: Perspectives On Covid-19 Prevention and Knowledgementioning

confidence: 98%

Perceptions of Romanian Physicians on Lockdowns for COVID-19 Prevention

Dima

Balaban

Jurcuţ³

et al. 2021

Healthcare

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“…The simulations of the measures' effects in containing the virus spread in Romania below were made in AnyLogic 8, based on a data set that should be adjusted and adapted to different regions. As input, the model uses the Romanian population divided into three age groups: 0-19, 20-59, and 60 years or older, according to national severity profiles which show a higher incidence of severe COVID-19 cases and deaths in the 60+ age group, due to existing comorbidities (59). The number of days between being infected to becoming infectious is, on average, 5.1 days (60,61), and the time being infectious 5.0 (62).…”

Section: The Choice Of An Epidemiological Modelmentioning

confidence: 99%

A Multi-Criteria Framework for Pandemic Response Measures

Ekenberg

Mihai

Fasth

et al. 2021

Front. Public Health

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In managing the COVID-19 pandemic, several compelling narratives seem to have played a significant role in the decision-making processes regarding which risk mitigation and management measures to implement. Many countries were to a large extent unprepared for such a situation, even though predictions about a significant probability for a pandemic to occur existed, and national governments of several countries often acted in an uncoordinated manner, which resulted in many inconsistencies in the disaster risk reduction processes. Limited evidence has also made room for strategic narratives meant to persuade the public of the chosen set of actions, even though the degree of uncertainty regarding the outcomes of these was high, further complicating the situation. In this article, we assume a normative standpoint regarding rhapsodic decision making and suggest an integrated framework for a more elaborated decision analysis under the ambiguity of how to contain the virus spread from a policy point of view, while considering epidemiologic estimations and socioeconomic factors in a multi-stakeholder-multi-criteria context based on a co-creative work process for eliciting attitudes, perceptions, as well as preferences amongst relevant stakeholder groups. The framework, applied in our paper on Romania for demonstrative purposes, is used for evaluating mitigation measures for catastrophic events such as the COVID-19 situation, to mobilize better response strategies for future scenarios related to pandemics and other hazardous events, as well as to structure the production and analysis of narratives on the current pandemic effects.

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“…In this way, chronic inflammation in vessel structure is a pathological process that acts as a crucial contributor to the development of hypertension [ [19] , [20] , [21] ]. Investigations have reported that hypertension, diabetes, and cardiovascular diseases were the most prevalent comorbidities among patients with COVID-19, in which hypertension appeared consistently as the most prevalent risk factor [ [22] , [23] , [24] , [25] ].…”

Section: Figmentioning

confidence: 99%