Debilitating Metastatic Spindle Cell Carcinoma of the Breast

Alexander, Jonathan S; Hashmi, Hamza; Reynolds, Samuel

doi:10.7759/cureus.3864

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Tumours are commonly large, well-circumscribed, cyst-containing lesions that are most frequently located in the upper outer quadrant of the breast [14] . At the time of initial diagnosis, numerous spindle cell carcinomas tend to be large and localised, with histopathological examination often showing well-defined margins or a partially nodular appearance [15] .…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Carcinoma of the Breast in a Patient with Previous History of Rectal Cancer: A Case Report

Al-Mallah,

Al-Najafi,

Zakaria

2022

Forum of Clinical Oncology

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Background Spindle cell carcinoma of the breast is a very rare subtype of metaplastic breast cancer with aggressive behaviour in comparison with invasive ductal carcinoma, which is the most common histological type of breast cancer. It has a poor prognosis and a controversial response to systemic therapy. Aim of this study The aim of this study is to shed light on this uncommon but aggressive type of breast cancer. Case Presentation In this case report, we present a 56-year-old woman with spindle cell carcinoma of the breast with a previous history of treated rectal cancer. She presented with a left breast mass. Ultrasound-guided fine needle aspiration gave results positive for malignancy. A left mastectomy with axillary clearance was done, and the histopathology was spindle cell carcinoma of the breast. The patient refused chemotherapy until five months post-operation when she presented with local recurrence of two small masses at the site of mastectomy. New imaging revealed bilateral pulmonary metastasis. She started on single agent Adriamycin and received a total of six cycles. A CT scan of the chest and abdomen with contrast revealed disease progression. Imaging of the brain showed brain metastasis. The patient refused any kind of further chemotherapy or radiotherapy treatment until she passed away one month later from aspiration pneumonia and its complications. Conclusion Metaplastic breast cancer is an aggressive subtype of breast cancer with rapid progression, a high tendency for distant metastases, a poor response to treatment, and a short survival time.

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Section: Discussionmentioning

confidence: 99%

Spindle Cell Carcinoma of the Breast in a Patient with Previous History of Rectal Cancer: A Case Report

Al-Mallah,

Al-Najafi,

Zakaria

2022

Forum of Clinical Oncology

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“…Spindle cell sarcomas are rare lesions of the breast which range from benign to highgrade malignant carcinomas, with a prevalence of less than 0.5% per year [1][2][3]. Differential diagnosis of these lesions includes sarcomatoid/metaplastic carcinoma, primary breast sarcoma, and phyllodes tumor (PT) [4].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of High-Grade Spindle Cell Sarcoma of the Breast: A Case Report

Tharwani,

Habib,

Ahmed

et al. 2024

Case Rep Oncol

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Introduction: Spindle cell sarcomas are rare breast lesions which are difficult to diagnose due to resemblance with other breast lesions. Histopathological examination and immunohistochemical staining are essential for diagnosis. Case Presentation: We present a rare case of a 15-year-old female presenting with high-grade rapidly progressive spindle cell sarcoma of the breast, differentiated as phyllodes tumor, with axillary lymph node involvement. Her lesion, on the left breast, measured 16.9 × 10.1 × 13.7 cm. Histology revealed malignant neoplasm arranged in sheets and individual neoplastic cells with an epithelioid to spindled morphology with scant cytoplasm and irregular nuclear membranes. Immunohistochemistry showed weakly positive focal CD-99, and negative WT-1, Myogenin, Desmin, p63, Cytokeratin, Synaptophysin, and CD-34 markers. She was successfully managed with modified radical mastectomy and discharged with regular follow-up advised. Conclusion: Spindle cell sarcomas have a very aggressive course and prompt diagnosis, and management is mandatory for better patient outcomes. Modified radical mastectomy is the mainstay of treatment.

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Debilitating Metastatic Spindle Cell Carcinoma of the Breast

Cited by 2 publications

References 8 publications

Spindle Cell Carcinoma of the Breast in a Patient with Previous History of Rectal Cancer: A Case Report

Spindle Cell Carcinoma of the Breast in a Patient with Previous History of Rectal Cancer: A Case Report

A Rare Case of High-Grade Spindle Cell Sarcoma of the Breast: A Case Report

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