Deceleration capacity: A novel predictor for total mortality in patients with non-ischemic dilated cardiomyopathy

Demming, Thomas; Sandrock, Sarah; Kühn, Christian; Kotzott, Laura; Tahmaz, Nihat; Bonnemeier, Hendrik

doi:10.1016/j.ijcard.2016.06.205

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Beside HRT, the main elements which determine the sympathetic-parasympathetic balance should include the heart rhythm variability and the acceleration/deceleration capacity. Their significance has been proven in many conditions, including coronary disease, heart failure, hypertension, and liver diseases, including cirrhosis [ 15 , 16 , 18 , 39 – 41 ]. The autonomic balance evaluation is also carried out by means of other methods.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C

Poliwczak

Białkowska

Wożny

et al. 2020

aoms

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Introduction Cardiovascular diseases are ranked as the third cause of mortality among people infected with hepatitis C virus (HCV), but the relationship of infection with cardiovascular risk remains disputable. We have focused on the comprehensive use of parameters obtainable during long-term electrocardiographic (ECG) Holter monitoring. Material and methods Heart rate variability and turbulence (HRV and HRT), deceleration/acceleration capacity (DC/AC), corrected QT interval (QTc) and late potential (LP) were used. 36 persons were included, and 30 healthy subjects formed a control group. All were submitted to 24-hour Holter ECG-monitoring. Results The studied groups were not statistically significantly different with regards to basic anthropometric parameters. Statistically significantly higher medium and maximum heart rhythm and aminotransferase activities were recorded in patients with hepatitis C. The HRV parameters r-MSSD, p50NN, HF, and absolute DC/AC values were significantly lower in the subjects with hepatitis C than those in the control group. The QTc interval, measured for nocturnal hours, was also significantly longer in that group. There were no differences in the albumin level or basic echocardiographic parameters, including left ventricle ejection fraction. Nor was there any difference in the HRT parameters, or LP. The most interesting observation was the positive correlation among the number of viral RNA copies and DC, and LF. Conclusions We confirmed the presence of autonomic disorders with prevalence of sympathetic system activity and prolonged QTc interval in patients with chronic hepatitis C. Those parameters significantly correlated with infection intensity. Our results suggest that HCV infection could be an independent cardiovascular risk factor, not associated with the lipid profile. Further prospective studies are needed.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C

Poliwczak

Białkowska

Wożny

et al. 2020

aoms

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“…The DC has been shown to be a powerful predictor of adverse outcomes in various heart diseases 3‐5 . Therefore, in the present study, we explored the relationship between DC before treatment initiation and cardiotoxicity, as assessed by decreased LVEF during a 2‐year follow‐up.…”

Section: What Is Known and Objectivementioning

confidence: 99%

Deceleration capacity of heart rate predicts trastuzumab‐related cardiotoxicity in patients with HER2‐positive breast cancer: A prospective observational study

2020

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“…Only a few studies have examined the association of this novel marker with cardiac mortality in patients with DCM. In 201 patients with a 40-month follow-up, DC below 4.5 ms powerfully and independently predicted mortality [ 74 ]. Similar results were also published by Yang, where in 65 male patients, a DC < 4.72 ms was a significant predictor of cardiac mortality on a 60-month follow-up [ 75 ].…”

Section: Heart Rate Turbulence Deceleration Capacity Turbulence Onset...mentioning

confidence: 99%

Noninvasive electrocardiographic risk factors for sudden cardiac death in dilated ca rdiomyopathy: is ambulatory electrocardiography still relevant?

et al. 2023

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Risk stratification for sudden cardiac death in dilated cardiomyopathy is a field of constant debate, and the currently proposed criteria have been widely questioned due to their low positive and negative predictive value. In this study, we conducted a systematic review of the literature utilizing the PubMed and Cochrane library platforms, in order to gain insight about dilated cardiomyopathy and its arrhythmic risk stratification utilizing noninvasive risk markers derived mainly from 24 h electrocardiographic monitoring. The obtained articles were reviewed in order to register the various electrocardiographic noninvasive risk factors used, their prevalence, and their prognostic significance in dilated cardiomyopathy. Premature ventricular complexes, nonsustained ventricular tachycardia, late potentials on Signal averaged electrocardiography, T wave alternans, heart rate variability and deceleration capacity of the heart rate, all have both some positive and negative predictive value to identify patients in higher likelihood for ventricular arrhythmias and sudden cardiac death. Corrected QT, QT dispersion, and turbulence slope–turbulence onset of heart rate have yet to establish a predictive correlation in the literature. Although ambulatory electrocardiographic monitoring is frequently used in clinical practice in DCM patients, no single risk marker can be used for the selection of patients at high-risk for malignant ventricular arrhythmic events and sudden cardiac death who could benefit from the implantation of a defibrillator. More studies are needed in order to establish a risk score or a combination of risk factors with the purpose of selecting high-risk patients for ICD implantation in the context of primary prevention.

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Deceleration capacity: A novel predictor for total mortality in patients with non-ischemic dilated cardiomyopathy

Cited by 11 publications

References 21 publications

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C

Deceleration capacity of heart rate predicts trastuzumab‐related cardiotoxicity in patients with HER2‐positive breast cancer: A prospective observational study

Noninvasive electrocardiographic risk factors for sudden cardiac death in dilated ca rdiomyopathy: is ambulatory electrocardiography still relevant?

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