Decellularized tilapia fish skin: A novel candidate for tendon tissue engineering

Liu, Zhe; Yu, Ming-Zhao; Peng, Hao; Liu, Ruo-Tao; Lim, Thou; Zhang, Changqing; Zhu, Zhenzhong; Wei, Xiaojuan

doi:10.1016/j.mtbio.2022.100488

Cited by 12 publications

(10 citation statements)

References 54 publications

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“…In addition, cross-linked decellularized tilapia skin was found to have both improved function, as well as a positive contribution to cell proliferation in a retrospective cohort study by Liu and colleagues. The study emphasized the efficacy of this graft in the treatment of tendon repair [19] . Similarly, a prospective study examining the use of synthetic peptides obtained from tilapia piscidin in wound healing of the skin ((TP2, TP2-5, and TP2-6) found favorable effects in cell proliferation when treated with HaCaT keratinocytes.…”

Section: Resultsmentioning

confidence: 99%

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Use of Nile tilapia fish skin in treatment for burn victims

Ghosh,

Sánchez-Velazco,

Prem

et al. 2023

International Journal of Surgery: Global Health

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Burn injuries in the United States result in 1.1 million hospital admissions, with around 4500 deaths annually, according to the CDC. Although skin grafts have been the standard treatment since 1869, recent research suggests that tilapia skin could offer a safer and more effective alternative. This review aims to assess the strengths and knowledge gaps related to the usage of fish skin in burn patients. A systematic search was conducted on electronic databases, such as PubMed, Scopus, Web of Science, Clinicaltrials.gov, and Google Scholar, using relevant MESH keywords from 2018 to 2022. The search and analysis followed the “Preferred Reporting Items for Systematic Reviews and Meta-analysis” methodology. Data extraction utilized a template based on the Cochrane Consumers and Communication Review group’s extraction guidelines. Out of 166 studies identified, 12 relevant studies were extensively analyzed. The trials consistently demonstrated accelerated reepithelialization, improved patient compliance in managing burn-related pain, no immunologic or allergic reactions, reduced infection rates, shorter hospital stays, and decreased treatment costs when using fish skin. These findings suggest that fish skin is comparable to traditional treatments in terms of effectiveness and safety. Considering the discussed advantages, Nile tilapia fish skin emerges as a promising xenograft option for burn victims. However, further large-scale trials and studies are needed before its widespread and official implementation in burn centers. More research is required to establish the efficacy and safety of fish skin as a viable treatment modality.

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Section: Resultsmentioning

confidence: 99%

“…Liu and colleagues yield propitious results for using decellularized tilapia fish skin as an alternative for tendon tissue replacement. NTS has intrinsic properties, such as abundant collagen and mechanical strength to promote collagen fibers expression [19] .…”

Section: No Cytotoxicity Notedmentioning

confidence: 99%

Use of Nile tilapia fish skin in treatment for burn victims

Ghosh,

Sánchez-Velazco,

Prem

et al. 2023

International Journal of Surgery: Global Health

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“…Therefore, the authors claimed that DTFS with TDSCs is a promising therapeutic option for tendon tissue regeneration. 73 18 patch consisting of acellular tilapia fish skin (AFS) and chitosan (CS), for wound healing. Pregel CS containing vascular endothelial growth factor (VEGF) was linked to the acellular skin matrix.…”

Section: In-vivo Applicationsmentioning

confidence: 99%

“…The results of the in vivo study on the rat Achilles tendon defect model showed that the DTFS with cultured cells can help regenerate the tendon tissue. Therefore, the authors claimed that DTFS with TDSCs is a promising therapeutic option for tendon tissue regeneration 73 . Cao et al designed a hybrid skin patch consisting of acellular tilapia fish skin (AFS) and chitosan (CS), for wound healing.…”

Section: Acellular Fish Skinmentioning

confidence: 99%

Acellular fish skin for wound healing

Esmaeili

Biazar

Ebrahimi

et al. 2023

International Wound Journal

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Fish skin grafting as a new skin substitute is currently being used in clinical applications. Acceleration of the wound healing, lack of disease transmission, and low cost of the production process can introduce fish skin as a potential alternative to other grafts. An appropriate decellularization process allows the design of 3D acellular scaffolds for skin regeneration without damaging the morphology and extracellular matrix content. Therefore, the role of decellularization processes is very important to maintain the properties of fish skin. In this review article, recent studies on various decellularization processes as well as biological, physical, and mechanical properties of fish skin and its applications with therapeutic effects in wound healing were investigated.

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“…4,5 The decellularized tilapia skin (dTS) has emerged as a notable candidate for regenerative materials among various marine species. 6 It is known that the tilapia skin is rich in type I collagen and omega-3 fatty acids, attributing to its favorable traits such as good biocompatibility, low inflammatory responses, and excellent antibacterial activity. 7,8 A clinical report demonstrated that the tilapia skin as the graft support significantly promotes the healing rate of burn wounds.…”

Section: Introductionmentioning

confidence: 99%