Decentralized Finance (DeFi) is an emerging and revolutionizing field with notable uncertainties of reliability to be used on a mass scale. On the other hand, Artificial Intelligence (AI) has proved to be a crucial helping tool in numerous domains. In this study, we present a systematic review of the utility of AI in DeFi in terms of impact, reliability, and security and conduct exhaustive analysis. The review was motivated by an in-depth investigation of recently published literature that prioritized AI and DeFi in their research. This research, like many prior studies, examined the articles in terms of impact, reliability, and security. In addition, a new relevance score is introduced to better comprehend the quality of the content. According to investigation, the combination of AI and DeFi is one of the trending research topics that lacks adequate interpretations of black-box methodologies. Furthermore, it was discovered that one of the primary issues in DeFi is security, and numerous technologies, including blockchain technology and machine learning approaches, have been used to minimize such challenges. We hope that the gap addressed throughout this review will give insights to future researchers and practitioners, ultimately leading to new research opportunities in AI to bridge the gap of trust between peers and make the integration of DeFi more agile in the near future.