Deciphering cellular plasticity in pancreatic cancer for effective treatments

Uddin, Md. Hafiz; Zhang, Dingqiang; Muqbil, Irfana; El-Rayes, Bassel F.; Chen, Herbert; Philip, Philip A.; Azmi, Asfar S.

doi:10.1007/s10555-023-10164-5

Cited by 3 publications

(1 citation statement)

References 177 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both are considered low immunereactive cancers that represent either the limited infiltration of immune cells or the extensive infiltration of immunosuppressive T cells [36]. Pancreatic cancer has high cellular plasticity, meaning that the cancer cells can change and adapt to different microenvironments [37].…”

Section: A Common Feature In Both Pca and Pdacmentioning

confidence: 99%

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

Benzaquen,

Lawrence,

Taussky

et al. 2024

Cancers

View full text Add to dashboard Cite

Introduction: Crosstalk occurs between nerve and cancer cells. These interactions are important for cancer homeostasis and metabolism. Nerve cells influence the tumor microenvironment (TME) and participate in metastasis through neurogenesis, neural extension, and axonogenesis. We summarized the past and current literature on the interaction between nerves and cancer, with a special focus on pancreatic ductal adenocarcinoma (PDAC), prostate cancer (PCa), and the role of the nerve growth factor (NGF) in cancer. Materials/Methods: We reviewed PubMed and Google Scholar for the relevant literature on the relationship between nerves, neurotrophins, and cancer in general and specifically for both PCa and PDAC. Results: The NGF helped sustain cancer cell proliferation and evade immune defense. It is a neuropeptide involved in neurogenic inflammation through the activation of several cells of the immune system by several proinflammatory cytokines. Both PCa and PDAC employ different strategies to evade immune defense. The prostate is richly innervated by both the sympathetic and parasympathetic nerves, which helps in both growth control and homeostasis. Newly formed autonomic nerve fibers grow into cancer cells and contribute to cancer initiation and progression through the activation of β-adrenergic and muscarinic cholinergic signaling. Surgical or chemical sympathectomy prevents the development of prostate cancer. Beta-blockers have a high therapeutic potential for cancer, although current clinical data have been contradictory. With a better understanding of the beta-receptors, one could identify specific receptors that could have an effect on prostate cancer development or act as therapeutic agents. Conclusion: The bidirectional crosstalk between the nervous system and cancer cells has emerged as a crucial regulator of cancer and its microenvironment. Denervation has been shown to be promising in vitro and in animal models. Additionally, there is a potential relationship between cancer and psychosocial biology through neurotransmitters and neurotrophins.

show abstract

Section: A Common Feature In Both Pca and Pdacmentioning

confidence: 99%

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

Benzaquen,

Lawrence,

Taussky

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors

Yamamoto,

Ha,

Liu

et al. 2024

Neoplasia

View full text Add to dashboard Cite

Tumor energy metabolism: implications for therapeutic targets

Hu,

Liu,

Fang

et al. 2024

Mol Biomed

View full text Add to dashboard Cite

Tumor energy metabolism plays a crucial role in the occurrence, progression, and drug resistance of tumors. The study of tumor energy metabolism has gradually become an emerging field of tumor treatment. Recent studies have shown that epigenetic regulation is closely linked to tumor energy metabolism, influencing the metabolic remodeling and biological traits of tumor cells. This review focuses on the primary pathways of tumor energy metabolism and explores therapeutic strategies to target these pathways. It covers key areas such as glycolysis, the Warburg effect, mitochondrial function, oxidative phosphorylation, and the metabolic adaptability of tumors. Additionally, this article examines the role of the epigenetic regulator SWI/SNF complex in tumor metabolism, specifically its interactions with glucose, lipids, and amino acids. Summarizing therapeutic strategies aimed at these metabolic pathways, including inhibitors of glycolysis, mitochondrial-targeted drugs, exploitation of metabolic vulnerabilities, and recent developments related to SWI/SNF complexes as potential targets. The clinical significance, challenges, and future directions of tumor metabolism research are discussed, including strategies to overcome drug resistance, the potential of combination therapy, and the application of new technologies.

show abstract

Deciphering cellular plasticity in pancreatic cancer for effective treatments

Cited by 3 publications

References 177 publications

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

The Crosstalk between Nerves and Cancer—A Poorly Understood Phenomenon and New Possibilities

GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors

Tumor energy metabolism: implications for therapeutic targets

Contact Info

Product

Resources

About