Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach

Increasing research suggests that sphingolipid metabolism is essential for the progression and metastasis of cancer. The underlying mechanistic insight into the dysregulation of sphingolipid metabolism affecting pathways is poorly investigated. As a result, the goal of the current study was to glean knowledge from the systems biology approach to investigate how the sphingolipid metabolism affects the signal transduction network in non‐small cell lung cancer (NSCLC), the most common type of cancer in terms of occurrence and death globally. Our paper includes system‐level models representing the diseased and healthy states elucidating that sphingolipids and its enzymes mediate PI3K/AKT pathway. Notably, its activation of downstream signaling mediators has led to cancer growth. Considering the critical role of sphingolipids in NSCLC, our study advocates the target CERS6 which can be potentially inhibited using hsa‐miR‐520c‐3p to combat NSCLC for future precision medicine.

show abstract

MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective

Gulhane

Singh

2022

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

Nectin-4: a Tumor Cell Target and Status of Inhibitor Development

2023

View full text Add to dashboard Cite

Unraveling the Post-Translational Modifications and therapeutical approach in NSCLC pathogenesis

Gulhane¹,

Singh²

2023

Translational Oncology

Self Cite

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Deciphering miR-520c-3p as a probable target for immunometabolism in non-small cell lung cancer using systems biology approach

Cited by 5 publications

References 40 publications

MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective

MicroRNA‐520c‐3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective

Nectin-4: a Tumor Cell Target and Status of Inhibitor Development

Unraveling the Post-Translational Modifications and therapeutical approach in NSCLC pathogenesis

Contact Info

Product

Resources

About