2022
DOI: 10.26434/chemrxiv-2022-pxnv9-v2
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Deciphering O-glycoprotease substrate preferences with O-Pair Search

Abstract: O-glycoproteases are an emerging class of enzymes that selectively digest glycoproteins at positions decorated with specific O-linked glycans. O-glycoprotease substrates range from any O-glycoprotein (albeit with specific O-glycan modifications) to only glycoproteins harboring specific O-glycosylated sequence motifs, such as those found in mucin domains. Their utility for multiple glycoproteomic applications is driving the search to both discover new O-glycoproteases and to understand how structural features o… Show more

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