Deciphering Plasmonic Modality to Address Challenges in Disease Diagnostics

Derin, Esma; Erdem, Özgecan; İnci, Fatih

doi:10.1002/9783527830343.ch1

Cited by 4 publications

(4 citation statements)

References 98 publications

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“…Non-invasive biosensors typically facilitate signal acquisition such that health-related data can Trends in Biotechnology be rapidly processed [83]. Plasmonic biosensors, for instance, measure resonance shifts caused by the excitation of surface plasmons once biomolecular interaction occurs [84,85]. Despite their label-free nature that allows real-time and continuous measurements with high sensitivity, they still face limitations such as immobilization effects, steric hindrance with binding, and mass transport limitations [86].…”

Section: Ai-assisted Biosensors To Accelerate Clinical Decisionsmentioning

confidence: 99%

Smart materials: rational design in biosystems via artificial intelligence

Sagdic

Eş

Sitti

et al. 2022

Trends in Biotechnology

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Section: Ai-assisted Biosensors To Accelerate Clinical Decisionsmentioning

confidence: 99%

Smart materials: rational design in biosystems via artificial intelligence

Sagdic

Eş

Sitti

et al. 2022

Trends in Biotechnology

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“…There is an increasing demand for developing on-chip sensing platforms of biomolecules to meet the recent trends in personalized healthcare, rapid point-of-care diagnostics, etc., leading on-chip sensing as an active and expanding field of research [261]. A myriad of on-chip sensing techniques have already been developed based on different methodologies including optical, plasmonic, and electrical modalities, some of which have yet to develop into full-fledged commercial healthcare applications [262][263][264][265][266][267]. Recently, plasmonic devices have been getting particular attention in biosensing applications.…”

Section: On-chip Optical Detection Of Single Moleculesmentioning

confidence: 99%

A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices

Rahman

Islam

et al. 2022

Micromachines

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Single-molecule techniques have shifted the paradigm of biological measurements from ensemble measurements to probing individual molecules and propelled a rapid revolution in related fields. Compared to ensemble measurements of biomolecules, single-molecule techniques provide a breadth of information with a high spatial and temporal resolution at the molecular level. Usually, optical and electrical methods are two commonly employed methods for probing single molecules, and some platforms even offer the integration of these two methods such as optofluidics. The recent spark in technological advancement and the tremendous leap in fabrication techniques, microfluidics, and integrated optofluidics are paving the way toward low cost, chip-scale, portable, and point-of-care diagnostic and single-molecule analysis tools. This review provides the fundamentals and overview of commonly employed single-molecule methods including optical methods, electrical methods, force-based methods, combinatorial integrated methods, etc. In most single-molecule experiments, the ability to manipulate and exercise precise control over individual molecules plays a vital role, which sometimes defines the capabilities and limits of the operation. This review discusses different manipulation techniques including sorting and trapping individual particles. An insight into the control of single molecules is provided that mainly discusses the recent development of electrical control over single molecules. Overall, this review is designed to provide the fundamentals and recent advancements in different single-molecule techniques and their applications, with a special focus on the detection, manipulation, and control of single molecules on chip-scale devices.

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“…Next to the electrochemical sensing mechanism, optical modalities have been utilized mostly as biosensing platforms due to their noninvasive or minimally invasive interactions with biological specimens. ,− In this scope, the recent work on the plasmonic detection modality was able to measure SARS-CoV-2 N antibodies in unprocessed human serum within 15 min . In this study, recombinant N proteins as recognition elements to sense anti-nucleocapsid antibodies were immobilized on a gold surface.…”

Section: Recent Progress In Covid-19 Diagnostic Technologiesmentioning

confidence: 99%