Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids

Shaji, Maneesha; Tamada, Atsushi; Fujimoto, Kazuya; Muguruma, Keiko; Karsten, Stanislav L.; Yokokawa, Ryuji

doi:10.1039/d3lc00930k

Lab Chip

2024

DOI: 10.1039/d3lc00930k

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Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids

Maneesha Shaji,

Atsushi Tamada,

Kazuya Fujimoto

et al.

Abstract: The first global analysis of the cerebral organoid (CO) response to 3D microvasculature indicates elaborate crosstalk between COs and ECs and points out potential vascularization factors for brain organoid vascularization on a chip.

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Cited by 6 publications

References 87 publications

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Vascularized organoid-on-a-chip: design, imaging, and analysis

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Yang,

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Angiogenesis

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Vascularized organoid-on-a-chip: design, imaging, and analysis

Yu,

Yang,

Peng

et al. 2024

Angiogenesis

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Advancements in Microphysiological Systems: Exploring Organoids and Organ-on-a-Chip Technologies in Drug Development -Focus on Pharmacokinetics Related Organs-

Kimura,

Nishikawa,

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et al. 2024

Drug Metabolism and Pharmacokinetics

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Brain organoids: A new tool for modelling of neurodevelopmental disorders

Aili,

Maimaitiming,

Wang

et al. 2024

J Cellular Molecular Medi

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Neurodevelopmental disorders are mostly studied using mice as models. However, the mouse brain lacks similar cell types and structures as those of the human brain. In recent years, emergence of three‐dimensional brain organoids derived from human embryonic stem cells or induced pluripotent stem cells allows for controlled monitoring and evaluation of early neurodevelopmental processes and has opened a window for studying various aspects of human brain development. However, such organoids lack original anatomical structure of the brain during maturation, and neurodevelopmental maturation processes that rely on unique cellular interactions and neural network connections are limited. Consequently, organoids are difficult to be used extensively and effectively while modelling later stages of human brain development and disease progression. To address this problem, several methods and technologies have emerged that aim to enhance the sophisticated regulation of brain organoids developmental processes through bioengineering approaches, which may alleviate some of the current limitations. This review discusses recent advances and application areas of human brain organoid culture methods, aiming to generalize optimization strategies for organoid systems, improve the ability to mimic human brain development, and enhance the application value of organoids.

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Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids

Abstract: The first global analysis of the cerebral organoid (CO) response to 3D microvasculature indicates elaborate crosstalk between COs and ECs and points out potential vascularization factors for brain organoid vascularization on a chip.

Cited by 6 publications

References 87 publications

Vascularized organoid-on-a-chip: design, imaging, and analysis

Vascularized organoid-on-a-chip: design, imaging, and analysis

Advancements in Microphysiological Systems: Exploring Organoids and Organ-on-a-Chip Technologies in Drug Development -Focus on Pharmacokinetics Related Organs-

Brain organoids: A new tool for modelling of neurodevelopmental disorders

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