“…Obvious possible candidates include neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and Creutzfeld-Jacob disease. The role of intracellular Ca 2+ in general and of ER Ca 2+ in particular (Ureshino et al, 2019;da Costa et al, 2020;Lim et al, 2021;Callens et al, 2021;Kovacs et al, 2021;Guan et al, 2021;Huang et al, 2022;Ge et al, 2022;Kim et al, 2022) as well as of ER stress and accumulation of misfolded proteins (da Costa et al, 2020;Guan et al, 2021;Kim et al, 2022;Ren et al, 2021;Yasmeen et al, 2022;Shacham et al, 2019;Chakraborty et al, 2005) have indeed already been demonstrated in several neurodegenerative diseases.…”