Deciphering the parameters to produce highly reproducible and scalable iron oxide nanoparticles

Avasthi, Ashish; Caro, Carlos; García-Martín, María Luisa; Leal, Manuel Pernía

doi:10.1039/d2re00516f

Cited by 6 publications

(4 citation statements)

References 75 publications

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“…The preparation of Fe 3 O 4 NPs of 18 nm was prepared with some modifications according to the procedure reported in a previous work . Briefly, 1 mmol iron oleate, 0.5 mmol oleic acid, and 10 g of 1-octadecene were mixed and heated to reflux for 1 h under a flow of argon.…”

Section: Methodsmentioning

confidence: 99%

“…The preparation of Fe 3 O 4 NPs of 18 nm was prepared with some modifications according to the procedure reported in a previous work. 36 Briefly, 1 mmol iron oleate, 0.5 mmol oleic acid, and 10 g of 1-octadecene were mixed and heated to reflux for 1 h under a flow of argon. Then, the reaction was washed several times with a mixture of ethanol, acetone, and isopropanol as precipitating agents and centrifuged followed by redispersion in toluene.…”

Section: Methodsmentioning

confidence: 99%

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Efficient Strategy to Synthesize Tunable pH-Responsive Hybrid Micelles Based on Iron Oxide and Gold Nanoparticles

Gimeno-Ferrero,

de Jesús,

Leal

2024

Langmuir

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The preparation of multifunctional nanomaterials based on inorganic nanoparticles with organic materials has emerged as a promising strategy for the development of new nanomedicines for in vitro and in vivo biomedical applications. Here, we synthesized pH-responsive hybrid inorganic micelles by combining a novel pH-responsive amphiphilic molecule with hydrophobic payloads. This amphiphile was synthesized in a one-pot reaction and self-assembled readily into micelles under acidic pH conditions. In the presence of hydrophobic NP payloads such as AuNPs or IONPs, the amphiphile self-organized around them through hydrophobic interactions, resulting in the formation of colloidally stable hybrid micelles. The size of the hydrophobic NPs determined the pH-response of the inorganic hybrid micelles, which is tuned from pH 7 to 11 for our pH-responsive amphiphilic molecule. This achievement represents a novel approach for the synthesis of tunable pH-responsive hybrid micelles based on inorganic NPs for biomedical imaging, hyperthermia treatment, and also drug delivery nanosystems.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Efficient Strategy to Synthesize Tunable pH-Responsive Hybrid Micelles Based on Iron Oxide and Gold Nanoparticles

Gimeno-Ferrero,

de Jesús,

Leal

2024

Langmuir

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“…Subsequently, the samples were sonicated for 30 min, followed by a 5 min decantation before measurements at room temperature. Upon observation of sings of sedimentation, samples were subjected to hand shake for 15 s when necessary (Sandler et al, 2019;Avasthi et al, 2023).…”

Section: Interfacial Properties In Bio-relevant Fluidsmentioning

confidence: 99%

Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen

Torres,

Cadena Castro,

Ancarani

et al. 2024

Front. Nanotechnol.

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Magnetic hybrid nanomaterials offer promising properties for the advancement of nanoplatforms in cancer nanomedicine, particularly in drug delivery applications. These nanoplatforms can effectively respond to various stimuli present at the tumor site, such as pH and temperature fluctuations, allowing for controlled and triggered release of therapeutic payloads. In this study, we present a straightforward methodology for the synthesis of stable hybrid magnetic nanoplatforms (HMNP) based on Fe3O4 nanoparticles, L-cysteine (L-Cys), and hyaluronic acid (HA) as key constituents for the delivery of tamoxifen (TMX). The synthesized superparamagnetic HMNP, Fe3O4-L-Cys-HA, with a size of 11 nm, was successfully loaded with TMX. The incorporation of L-Cys showed superior interaction with the surface of Fe3O4 nanoparticles compared to other L-Cys derivatives explored as ligands. Consequently, L-Cys was selected for further functionalization with HA, providing the HMNP with active targeting properties toward CD44-overexpressed receptors. High loading efficiency of TMX (75%) was achieved via electrostatic interaction between the carboxylate groups exposed by the HMNP and the ammonium group of the TMX side chain. Efficient control in the TMX release towards different receptor media was observed. Notably, the release of TMX from HMNP-TMX was triggered under acidic pH and hyperthermia conditions, showcasing its responsiveness to both stimuli. Furthermore, enhanced anticancer activity of TMX against MDA-MB-231 breast cancer cells was observed when loaded into HMNP (IC50 almost 3-fold lower for HMNP-TMX compared to free TMX), indicating improved cell uptake of TMX-loaded HMNP in comparison to the free drug. Overall, pH/temperature dual-sensitive HMNP demonstrates promising potential as a nanoplatform for cancer nanomedicine, with prospects for magnetic hyperthermia therapy.

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“…19–22 The optimization of the synthetic route is of utmost importance since a small variation in the preparative conditions can significantly impact the final outcome. 23–26 Among the more popular methods are coprecipitation, thermal decomposition, microemulsion, and hydrothermal. 27–29 Coprecipitation is perhaps the simplest of all: the precipitation of a 1 : 1 molar mixture of Fe( ii ) and Fe( iii ) salts in the basic medium at ambient conditions.…”

Section: Introductionmentioning

confidence: 99%

Low-cost one-pot synthesis of hydrophobic and hydrophilic monodispersed iron oxide nanoparticles

Reja,

Kumar,

Vasudevan

2024

Nanoscale Adv.

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Deciphering the parameters to produce highly reproducible and scalable iron oxide nanoparticles

Abstract: This article introduces a modified method to yield small IONPs (∼4 nm) with high reproducibility and scalability after revisiting established synthesis methods and investigating the effect of variations in several parameters involved in these methods.

Cited by 6 publications

References 75 publications

Efficient Strategy to Synthesize Tunable pH-Responsive Hybrid Micelles Based on Iron Oxide and Gold Nanoparticles

Efficient Strategy to Synthesize Tunable pH-Responsive Hybrid Micelles Based on Iron Oxide and Gold Nanoparticles

Magnetic hybrid nanomaterial based on a natural polymer and an amino acid as pH/temperature dual-responsive nanoplatform for the delivery of tamoxifen

Low-cost one-pot synthesis of hydrophobic and hydrophilic monodispersed iron oxide nanoparticles

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