Decline in semen quality among 30,636 young Chinese men from 2001 to 2015

Huang, Chuan; Li, Baishun; Xu, Kongrong; Liú, Dan; Hu, Jie; Yang, Yang; Nie, Hongchuan; Fan, Liqing; Zhu, Wenbing

doi:10.1016/j.fertnstert.2016.09.035

Cited by 141 publications

(85 citation statements)

References 32 publications

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“…Because estrogenic chemicals have become both increasingly common and ubiquitous environmental contaminants in developed countries, the implications for humans are serious. Indeed, it is possible effects are already apparent, with population-based studies from the U.S., Europe, Japan, and China reporting reductions in sperm counts/quality [2,3,5,6,50–53] and male fertility (reviewed in [7]) within a span of several decades.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a comprehensive analysis in 2000 of data from more than 100 studies in Western countries provided evidence of a decline in human spermatogenesis during the preceding 50 years [1]. More recent longitudinal cross-sectional studies suggest reductions in both sperm count and quality among young men (ages 18–37) in China (2001–2015;[2]), Spain (2001–2011;[3]), France (1989–2005;[4]), Denmark (1996–2010;[5]), and Finland (1998–2006; [6]). Changes in sperm production have coincided with increases in the incidence of other reproductive defects, including hypospadias, cryptorchidism, and testicular germ cell cancers (reviewed in [7]), and the combined spectrum of reproductive effects has been termed testicular dysgenesis syndrome (TDS; [8]).…”

Section: Introductionmentioning

confidence: 99%

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Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

et al. 2017

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The hypothesis that developmental estrogenic exposure induces a constellation of male reproductive tract abnormalities is supported by experimental and human evidence. Experimental data also suggest that some induced effects persist in descendants of exposed males. These multi- and transgenerational effects are assumed to result from epigenetic changes to the germline, but few studies have directly analyzed germ cells. Typically, studies of transgenerational effects have involved exposing one generation and monitoring effects in subsequent unexposed generations. This approach, however, has limited human relevance, since both the number and volume of estrogenic contaminants has increased steadily over time, intensifying rather than reducing or eliminating exposure. Using an outbred CD-1 mouse model, and a sensitive and quantitative marker of germline development, meiotic recombination, we tested the effect of successive generations of exposure on the testis. We targeted the germline during a narrow, perinatal window using oral exposure to the synthetic estrogen, ethinyl estradiol. A complex three generation exposure protocol allowed us to compare the effects of individual, paternal, and grandpaternal (ancestral) exposure. Our data indicate that multiple generations of exposure not only exacerbate germ cell exposure effects, but also increase the incidence and severity of reproductive tract abnormalities. Taken together, our data suggest that male sensitivity to environmental estrogens is increased by successive generations of exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

et al. 2017

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“…A possible decline in world seminal parameters has been suggested by several researchers. A study published in 2017 noted a decline in seminal quality in young Chinese men over a 15-year period 4 . Over the past 35 years, an average 57% decline in sperm concentration has been reported worldwide 5 .…”

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confidence: 99%

Changes in seminal parameters among Brazilian men between 1995 and 2018

Siqueira

Ropelle

Nascimento

et al. 2020

Sci Rep

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Aiming to investigate trends in seminal parameter values among Brazilian men between 1995 and 2018, we performed a retrospective analysis of spermograms of couples admitted for infertility testing at UNICAMP/Brazil. For the present study, only the first sample produced by each man was analyzed (9,267 samples). Total motile sperm count (TMSC), percentage of spermatozoa with normal morphology (NM), and sperm concentration after seminal processing (SCA) were considered dependent variables. Statistical analysis was carried out through linear regression for the median values both in the general population and in the population categorized by age group (<30, 30-39, and ≥40 years). During the study period, the mean age of men was 32.46 (± 6.48) years, with a median of 32 (18-67) years. We found a significant decrease in the median values of TMSC (reduction of 2.84 million/year), NM (reduction of 0.52% each year) and SCA (reduction of 0.24 million/mL each year). In conclusion, we observed that Brazilian men undergoing infertility investigation had a decline in seminal parameters in the past 23 years. Surveillance should be maintained in the coming years, and further studies are needed to elucidate possible causes for seminal deterioration and to devise strategies to reverse this trend.

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“…Semen quality is an important factor that reflects male reproductive function. In China, the percentage of eligible sperm donors also showed a decreasing trend over the 15-year period, from 55.78% in 2001 to 17.80% in 2015, with the main reason for semen parameters including semen volume, sperm concentration, sperm motility were below the lower threshold of standard screening sperm donors (Huang et al, 2017). Unfortunately, in the past few decades, semen quality has been seen a marked decline even in healthy men.…”

mentioning

confidence: 99%

“…Unfortunately, in the past few decades, semen quality has been seen a marked decline even in healthy men.In addition, World Health Organization (WHO) has lowered the accepted values of normal sperm parameter, including count, motility and morphology, because over the past decades, these parameters have a significant decline in healthy men (Cooper et al, 2010; World Health Organization, 1999). In China, the percentage of eligible sperm donors also showed a decreasing trend over the 15-year period, from 55.78% in 2001 to 17.80% in 2015, with the main reason for semen parameters including semen volume, sperm concentration, sperm motility were below the lower threshold of standard screening sperm donors (Huang et al, 2017). In the United States, the number of assisted reproduction techniques increased 36% in…”

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confidence: 99%

Gasoline exhaust damages spermatogenesis through downregulating α6-integrin andβ1-integrinin the rat model

Luo

Zhao

et al. 2018

Andrologia

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The health influence of air pollution has been an international public health concern. Increasing evidence has suggested that air pollution has been associated with decreased sperm quality. However, the underlying molecular mechanisms are still not fully elucidated. We aimed to verify whether gasoline exhaust leads to reproductive impairment by injuring spermatogonial stem cells and explore its underlying molecular mechanism. Twenty male Sprague-Dawley rats were randomly divided into two groups: the exposure group (n = 10) and the control group (n = 10). After 6-month exposure, the sperm count and morphology were determined. The histological changes in the seminiferous tubules were examined by HE staining. The expression of α6-integrin and β1-integrin was assessed with Quantitative RT-PCR, Western blot and Immunohistochemical staining. Compared with control group, male rats exposed to gasoline exhaust showed significantly reduced sperm count, increased sperm abnormality rate and the total number of spermatogonia, primary spermatocytes, secondary spermatocytes, spermatids were decreased. (all p < .01). The expression levels of α6-integrin and β1-integrin in the exposure group were significantly lower than those in the control group (all p < .01). Our study showed that exposure to gasoline exhaust caused impairment to spermatogonial stem cells through downregulating α6-integrin and β1-integrin.

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Decline in semen quality among 30,636 young Chinese men from 2001 to 2015

Abstract: The semen quality among young Chinese men has declined over a period of 15 years, especially in terms of sperm concentration, total sperm count, sperm progressive motility, and normal morphology.

Cited by 141 publications

References 32 publications

Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure

Changes in seminal parameters among Brazilian men between 1995 and 2018

Gasoline exhaust damages spermatogenesis through downregulating α6-integrin andβ1-integrinin the rat model

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