Declining trends in syphilis prevalence among antenatal women in northern India: a 10-year analysis from a tertiary healthcare centre

Sethi, Sunil; Sharma, Kusum; Dhaliwal, Lakhbir Kaur; Banga, S. S.; Sharma, Mukut

doi:10.1136/sti.2007.025551

Cited by 16 publications

(16 citation statements)

References 3 publications

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“…11 This is comparable to the findings of Sethi et al who had observed a declining trend of VDRL reactivity from 1.82% in 1996 to 0.84% in 2005 among pregnant women in a 10 year analysis. 12 Our study also corroborates to the low prevalence of syphilis seroreactivity. The declining trend of STDs like syphilis is an indication of effective awareness campaign, awareness and management of these diseases and a result of their inclusion in national programmes.…”

Section: Discussionsupporting

confidence: 86%

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Seroprevalence of TORCH infection among pregnant women

Sahu¹,

Pradhan

Nayak

2019

Int J Community Med Public Health

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Background: TORCH infection complex during pregnancy has bad obstetric outcomes starting from low birth weight to congenital anomalies, sensory neural deafness, mental retardation, cerebral palsy and sometimes to fatal outcomes like abortion and still birth. As these diseases remain mostly asymptomatic these are rarely tested during pregnancy. Serology is the mainstay of diagnosing these infections..Methods: A cross sectional study was undertaken to estimate the burden of these infections in a rural belt of western Odisha where majority of the population depend upon agricultural work. A total number of 402 antenatal cases were screened by ELISA test for presence of IgG&IgM antibodies against toxoplasma, rubella virus, cytomegalovirus (CMV), herpes simplex virus (HSV) 1 & 2; RPR test was done to know seroprevalence of Syphilis.Results: It was found that Rubella is the most predominant infection being positive in 69.1% of the cases (IgG 68.4%, IgM 0.5%, and both IgG&IgM 0.25%), followed by CMV infection-66.7% (IgG 57.2%, IgM 1.7%, both 7.7%), Toxoplasma infection-39.8% (IgG 38.3%, IgM 0.7%, both 0.7%), HSV 1-23.6% (IgG 21.1%, IgM 2%, both 0.25%) and HSV 2 – 13.2% (IgG 11.7%, IgM 1.6%, both 0.25%). The seoprevalence of syphilis by RPR was least common with 0.5%.Conclusions: This study showed that most of the infections have occurred by 20 years of age and before or during the 1st pregnancy. It is less common among the antenatal cases who have better education and have spouses servicing in private or government sectors signifying the more health and sanitation awareness among this group.

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Section: Discussionsupporting

confidence: 86%

“…Due to massive campaign and screening programmes to control HIV and STDs and ready availability of antibiotics it is showing a downward trend. 11,12 Most of these infections remain asyptomatic and clinical diagnosis is unreliable. The diagnosis of these infections is mainly based upon the presence of serum antibodies, particularly IgM in patient's serum.…”

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confidence: 99%

Seroprevalence of TORCH infection among pregnant women

Sahu¹,

Pradhan

Nayak

2019

Int J Community Med Public Health

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“…24 Syphilis also contributes to stillbirths in other areas of the world including Russia, Asia, and South America. [30][31][32] Stillbirths due to syphilis should be easy to eliminate. Within a functioning health system, screening of pregnant women for syphilis is feasible, and once disease is diagnosed, treatment is easy and inexpensive.…”

Section: Transplacental Infections: Syphilis and Other Spirochaetesmentioning

confidence: 99%

Infection-related stillbirths

et al. 2010

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Infection is an important cause of stillbirth world-wide; in low and middle income countries (LMICs), 50% or more are likely caused by infection. In contrast, in high income countries, only10-25% of stillbirths are caused by infection. Syphilis, where prevalent, causes the majority of infectious stillbirths and is the infection most amenable to screening and treatment. Ascending bacterial infection is a common cause of stillbirth, but prevention has proven elusive. Many viral infections are causal for stillbirth but aside from vaccination for common childhood diseases, it is unclear how most viral-caused stillbirths may be prevented. Malaria, because of its high prevalence and extensive placental damage accounts for large numbers of stillbirths. Intermittent malarial prophylaxis and insecticide impregnated bed nets should decrease stillbirths. Many animal and vector-borne infections cause stillbirth. Because this relationship is especially important in LMICs, research that more clearly defines this relationship is crucial to reduce the unacceptably high stillbirth rates in those areas.

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“…Although a previous report from our center indicated a falling trend of syphilis in pregnant ladies, data regarding the prevalence in other groups is lacking. [5] Hence, this study was carried out to analyze the trends of seroprevalence of syphilis in pregnant ladies, drug addicts attending de-addiction clinic (intravenous drug user [IVDU]), HIV-positive patients attending antiretroviral treatment (ART) clinic, patients attending STD clinic and patients admitted in wards/out-patient departments (OPDs), at our tertiary care center in North India, from January 1, 2006 to December 31, 2011.…”

Section: Introductionmentioning

confidence: 99%

Rising trends of syphilis in a tertiary care center in North India

Sethi¹,

Mewara²,

Hallur³

et al. 2015

Indian J Sex Transm Dis

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Background and Objectives:Syphilis is a classical sexually transmitted disease (STD), caused by Treponema pallidum subsp. pallidum. In this retrospective study, we analyzed trends of syphilis prevalence in patient groups attending our tertiary care center.Materials and Methods:The data was obtained by reviewing laboratory records of the STD laboratory from January 1, 2006 to December 31, 2011. Cases positive by both Venereal Disease Research Laboratory (VDRL) and Treponema pallidum particle agglutination (TPPA) tests were analyzed for seroprevalence of syphilis in different groups, and to analyze the rising or falling trends, if any.Results:A total of 28,920 serum samples were received in the 6-year study period for VDRL testing, of which 972 (3.4%) were found to be reactive. Of these, 1722 sera were also submitted for TPPA testing, 374 (21.7%) of which were positive. A total of 375 samples were submitted for both tests, indicating biological false positivity of 0.27%. A rising trend, though not statistically significant, was observed in pregnant women, drug users and patients from wards/out-patient departments, while a statistically significant rise in prevalence of syphilis was found in HIV-positive individuals. A falling trend (not statistically significant) was observed in STD clinic attendees.Conclusion:An increasing trend of syphilis was observed during the study period when all groups were analyzed together, especially in HIV-seropositive individuals, which calls for continued and sustained efforts for case detection, treatment, and preventive measures to contain the disease.

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Declining trends in syphilis prevalence among antenatal women in northern India: a 10-year analysis from a tertiary healthcare centre

Cited by 16 publications

References 3 publications

Seroprevalence of TORCH infection among pregnant women

Seroprevalence of TORCH infection among pregnant women

Infection-related stillbirths

Rising trends of syphilis in a tertiary care center in North India

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