Decoding Serine Metabolism: Unveiling Novel Pathways for Evolving Cancer Therapies
Aristotle Lau,
John Blenis,
Guillermo Burgos-Barragan
Abstract:Serine metabolism plays a pivotal role in cancer, making it an appealing therapeutic target. Two recent studies published in Nature Metabolism and Science Translational Medicine uncovered novel players and therapeutic opportunities within this crucial metabolic pathway. Papalazarou and colleagues employed genetic tools coupled with metabolomics and high-throughput imaging to identify and characterize membrane transporters involved in serine uptake and mitochondrial import in colorectal cancer. Notably, they sh… Show more
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