Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Salmanton-García, Jon; Marchesi, Francesco; Farina, Francesca; Weinbergerová, Barbora; Itri, Federico; Dávila-Valls, Julio; Martín-Pérez, Sonia; Glenthøj, Andreas; Hersby, Ditte Stampe; Gomes Da Silva, Maria; Nunes Rodrigues, Raquel; López-García, Alberto; Córdoba, Raúl; Bilgin, Yavuz M.; Falces-Romero, Iker; El-Ashwah, Shaimaa; Emarah, Ziad; Besson, Caroline; Kohn, Milena; Van Doesum, Jaap; Ammatuna, Emanuele; Marchetti, Monia; Labrador, Jorge; Zambrotta, Giovanni Paolo Maria; Verga, Luisa; Jaksic, Ozren; Nucci, Marcio; Piukovics, Klára; Cabirta-Touzón, Alba; Jiménez, Moraima; Arellano, Elena; Espigado, Ildefonso; Blennow, Ola; Nordlander, Anna; Meers, Stef; Vian Praet, Jens; Aiello, Tommaso Francesco; Garcia-Vidal, Carolina; Fracchiolla, Nicola S.; Sciumè, Mariarita; Seval, Guldane Cengiz; Žák, Pavel; Buquicchio, Caterina; Tascini, Carlo; Gräfe, Stefanie K.; Schönlein, Martin; Adžić-VUKIČEVIĆ, Tatjana; Bonuomo, Valentina; Cattaneo, Chiara; Nizamuddin, Summiya; Čerňan, Martin; Plantefeve, Gaëtan; Prin, Romane; Szotkovski, Tomas; Collins, Graham P.; Dargenio, Michelina; Petzer, Verena; Wolf, Dominik; Čolović, Natasha; Prezioso, Lucia; Valković, Toni; Passamonti, Francesco; Méndez, Gustavo-Adolfo; Sili, Uluhan; Vena, Antonio; Bavastro, Martina; Limongelli, Alessandro; Duarte, Rafael F.; Ledoux, Marie-Pierre; Cvetanoski, Milche; Stojanoski, Zlate; Machado, Marina; Batinić, Josip; Magliano, Gabriele; Biernat, Monika M.; Pantić, Nikola; Poulsen, Christian Bjørn; Cuccaro, Annarosa; Del Principe, Maria Ilaria; Kulasekararaj, Austin; Ormazabal-Vélez, Irati; Busca, Alessandro; Demirkan, Fatih; Ijaz, Marriyam; Klimko, Nikolai; Stoma, Igor; Khostelidi, Sofya; Fernández, Noemí; Omrani, Ali S.; Bergantim, Rui; De Jonge, Nick; Fouquet, Guillemette; Navrátil, Milan; Abu-Zeinah, Ghaith; Samarkos, Michail; Maertens, Johan; De Ramón, Cristina; Guidetti, Anna; Magyari, Ferenc; González-López, Tomás José; Lahmer, Tobias; Finizio, Olimpia; Ali, Natasha; Pinczés, László Imre; Lavilla-Rubira, Esperanza; Romano, Alessandra; Merelli, Maria; Delia, Mario; Calbacho, Maria; Meletiadis, Joseph; Antić, Darko; Hernández-Rivas, José-Ángel; Marques De Almeida, Joyce; Al-Khabori, Murtadha; Hoenigl, Martin; Tisi, Maria Chiara; Khanna, Nina; Barać, Aleksandra; Eisa, Noha; Di Blasi, Roberta; Liévin, Raphaël; Miranda-Castillo, Carolina; Bahr, Nathan C.; Lamure, Sylvain; Papa, Mario Virgilio; Yahya, Ayel; Aujayeb, Avinash; Novák, Jan; Erben, Nurettin; Fernández-Galán, María; Ribera-Santa Susana, José-María; Rinaldi, Ikhwan; Fazzi, Rita; Piedimonte, Monica; Duléry, Rémy; Gonzaga, Yung; Soto-Silva, Andrés; Sapienza, Giuseppe; Serris, Alexandra; Drgoňa, Ľuboš; Groh, Ana; Serrano, Laura; Gavriilaki, Eleni; Tragiannidis, Athanasios; Prattes, Juergen; Coppola, Nicola; Otašević, Vladimir; Mladenović, Miloš; Mitrović, Mirjana; Mišković, Bojana; Jindra, Pavel; Zompi, Sofia; Sacchi, Maria Vittoria; Krekeler, Carolin; Shumilov, Evgenii; Infante, Maria Stefania; García-Bordallo, Daniel; Çolak, Gökçe Melis; Cingolani, Antonella; Mayer, Jiří; Criscuolo, Marianna; Nygaard, Marietta; Hanáková, Michaela; Fianchi, Luana; Ráčil, Zdeněk; Giordano, Antonio; Quattrone, Martina; Bonanni, Matteo; Koehler, Philipp; Rahimli, Laman; Cornely, Oliver A.; Pagano, Livio; Martín-Vallejo, Francisco Javier; Zdziarski, Przemyslaw; Zarrinfer, Hossein; Wittig, Jana; Win, Sein; Wai-Man, Vivien; Víšek, Benjamín; Vinh, Donald C.; Vehreschild, Maria; Varricchio, Gina; Tsirigotis, Panagiotis; Torres-Tienza, Ana; Tanase, Alina Daniela; Tafuri, Agostino; Stamouli, Maria; Sramek, Jiří; Soussain, Carole; Shirinova, Ayten; Schubert, Jörg; Schalk, Enrico; Salehi, Mohammad Reza; Saleh, Modar; Rosati, Giorgio; Roldán, Elisa; Reizine, Florian; Rêgo, Mayara; Regalado-Artamendi, Isabel; Popova, Marina; Pinto, Fernando; Philippe, Laure; Orth, Hans Martin; Ommen, Hans-Beier; Obr, Aleš; Núñez-Martín-Buitrago, Lucía; Noël, Nicolas; Neuhann, Julia; Nadali, Gianpaolo; Nacov, Julia A.; Munhoz Alburquerque, Ana M.; Mitra, Maria Enza; Mikulska, Malgorzata; Mellinghoff, Sibylle; Mechtel, Ben; Martín-González, Juan-Alberto; Malak, Sandra; Loureiro-Amigo, Jorge; Lorenzo De La Peña, Lisset; Liberti, Giulia; Landau, Marianne; Lacej, Ira; Kolditz, Martin; Kho, Chi Shan; Khedr, Reham Abdelaziz; Karthaus, Meinolf; Karlsson, Linda Katharina; Jiménez-Lorenzo, María-Josefa; Izuzquiza, Macarena; Hoell-Neugebauer, Baerbel; Herbrecht, Raoul; Heath, Christopher H.; Guolo, Fabio; Grothe, Jan; Giordano, Antonio; Gerasymchuk, Sergey; García-Sanz, Ramón; García-Poutón, Nicole; Funke, Vaneuza Araújo Moreira; Fung, Monica; Flasshove, Charlotte; Fianchi, Luana; Essame, Jenna; Egger, Matthias; Drenou, Bernard; Dragonetti, Giulia; Desole, Maximilian; Della Pepa, Roberta; Deau Fischer, Bénédicte; De Kort, Elizabeth; De Cabo, Erik; Danion, François; Daguindau, Etienne; Cushion, Tania; Cremer, Louise; Criscuolo, Marianna; Cordini, Gregorio; Cingolani, Antonella; Ciceri, Fabio; Chowdhury, Fazle Rabbi; Chelysheva, Ekaterina; Chauchet, Adrien; Chai, Louis Yi Ann; Ceesay, M. Mansour; Busch, Elena; Brehon, Mathias; Borducchi, Davimar M.M.; Booth, Stephen; Bologna, Serge; Berg Venemyr, Caroline; Bailén-Almorox, Rebeca; Antoniadou, Anastasia; Anastasopoulou, Amalia N.; Altuntaş, Fevzi

doi:10.1016/j.eclinm.2024.102553

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…HSCT is a crucial and sometimes curative treatment approach for various hematological malignancies [122]. COVID-19 disease formed a challenge for both transplant physicians and their vulnerable patients [123]. Endothelial dysfunction, complement dysregulation, and the activation of coagulation cascade are implemented in the pathogenesis of various HSCT complications, which can be described as endotheliopathies.…”

Section: Discussionmentioning

confidence: 99%

Genetic Susceptibility in Endothelial Injury Syndromes after Hematopoietic Cell Transplantation and Other Cellular Therapies: Climbing a Steep Hill

Evangelidis,

Kalmoukos

et al. 2024

CIMB

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Hematopoietic stem cell transplantation (HSCT) remains a cornerstone in the management of patients with hematological malignancies. Endothelial injury syndromes, such as HSCT-associated thrombotic microangiopathy (HSCT-TMA), veno-occlusive disease/sinusoidal obstruction syndrome (SOS/VOD), and capillary leak syndrome (CLS), constitute complications after HSCT. Moreover, endothelial damage is prevalent after immunotherapy with chimeric antigen receptor-T (CAR-T) and can be manifested with cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS). Our literature review aims to investigate the genetic susceptibility in endothelial injury syndromes after HSCT and CAR-T cell therapy. Variations in complement pathway- and endothelial function-related genes have been associated with the development of HSCT-TMA. In these genes, CFHR5, CFHR1, CFHR3, CFI, ADAMTS13, CFB, C3, C4, C5, and MASP1 are included. Thus, patients with these variations might have a predisposition to complement activation, which is also exaggerated by other factors (such as acute graft-versus-host disease, infections, and calcineurin inhibitors). Few studies have examined the genetic susceptibility to SOS/VOD syndrome, and the implicated genes include CFH, methylenetetrahydrofolate reductase, and heparinase. Finally, specific mutations have been associated with the onset of CRS (PFKFB4, CX3CR1) and ICANS (PPM1D, DNMT3A, TE2, ASXL1). More research is essential in this field to achieve better outcomes for our patients.

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Section: Discussionmentioning

confidence: 99%

Genetic Susceptibility in Endothelial Injury Syndromes after Hematopoietic Cell Transplantation and Other Cellular Therapies: Climbing a Steep Hill

Evangelidis,

Kalmoukos

et al. 2024

CIMB

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Viral infection after hematopoietic stem cell transplantation

Ljungman

2024

Current Opinion in Hematology

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Purpose of review Viral infections are important complications after allogeneic hematopoietic stem cell transplantation. New infections develop such as SARS-CoV-2 with the potential for severe consequences. In this review, newly published information regarding management of viral infections is discussed. Recent findings Letermovir and maribavir are antiviral agents that have positively impacted the management of cytomegalovirus infections. These should today be included in treatment algorithms. The first antiviral cellular therapy for anti-CD20 refractory EBV-associated lymphoproliferative disease is now licensed and available. Vaccination as well as introduction of antiviral agents, mAbs and possibly the development of different viral strains have reduced mortality in COVID-19 in this patient population. Well designed studies have shown the improved immunogenicity of high-dose influenza vaccines. There is still an unmet medical need for patients infected with human metapneumovirus and parainfluenza viruses. Summary Although improvements in patient management for several important posttransplantation viral infections have been reported, an unmet medical need still exists for other viruses occurring in this high-risk population.

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Outcomes and Patterns of Evolution of Patients with Hematological Malignancies during the COVID-19 Pandemic: A Nationwide Study (2020–2022)

Garcia-Carretero,

Ordoñez-Garcia,

Gil-Prieto

et al. 2024

JCM

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Background: Early reports suggest that hematological malignancy (HM) is a relevant risk factor for morbidity and mortality in COVID-19. We investigated the characteristics, outcomes, and risk factors for mortality in patients hospitalized with HM and COVID-19. Methods: We conducted a retrospective, nationwide study using data from hospitalized patients that were provided by the Spanish Ministry of Health including all patients admitted to a Spanish hospital from 2020 to 2022 with a COVID-19 diagnosis. A descriptive analysis and correlational analyses were conducted. Logistic regression was used to assess mortality in these patients and to calculate odds ratios (ORs). Results: We collected data on 1.2 million patients with COVID-19, including 34,962 patients with HMs. The incidence of hospitalization for patients with HMs was 5.8%, and the overall mortality rate was higher than for patients without HMs (19.8% versus 12.7%, p = 0.001). Mortality rates were higher for patients with lymphomas, multiple myelomas, and leukemias than for those with myeloproliferative disorders. Having HMs was a risk factor for mortality, with OR = 1.7 (95% CI 1.66–1.75, p = 0.001). By subtype, non-Hodgkin lymphomas were the highest risk factor for mortality (OR = 1.7), followed by leukemias (OR = 1.6), Hodgkin lymphomas (OR = 1.58), and plasma cell dyscrasias (OR = 1.24). Conclusions: This study identifies the different clinical profiles of patients with HMs who are at a high risk for mortality when hospitalized with COVID-19. As members of a vulnerable population, these patients deserve special prophylactic and therapeutic measures to minimize the effects of SARS-CoV-2 infection.

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Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Cited by 3 publications

References 38 publications

Genetic Susceptibility in Endothelial Injury Syndromes after Hematopoietic Cell Transplantation and Other Cellular Therapies: Climbing a Steep Hill

Genetic Susceptibility in Endothelial Injury Syndromes after Hematopoietic Cell Transplantation and Other Cellular Therapies: Climbing a Steep Hill

Viral infection after hematopoietic stem cell transplantation

Outcomes and Patterns of Evolution of Patients with Hematological Malignancies during the COVID-19 Pandemic: A Nationwide Study (2020–2022)

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