Deconvolution of laser based images for monitoring rheumatoid arthritis

Abstract

Optical imaging in biomedicine is governed by the light absorption and scattering interaction on microscopic and macroscopic constituents in the medium. Therefore, light scattering characteristics of human tissue correlate with the stage of some diseases. In the near infrared range the scattering event with the coefficient approximately two orders of magnitude greater than absorption plays a dominant role. When measuring the optical parameters variations were discovered that correlate with the rheumatoid arthritis of a small joint. The potential of an experimental setup for transillumination of the finger joint with a laser diode and the pattern of the stray light detection are demonstrated. The scattering caused by skin contains no useful information and it can be removed by a deconvolution technique to enhance the diagnostic value of this non-invasive optical method. Monte Carlo simulations ensure both the construction of the corresponding point spread function and the theoretical verification of the stray light picture in rather complex geometry.

The characteristic time of glucose diffusion measured for muscle tissue at optical clearing

“…Such a tissue can be subjected to optical clearing to reduce such a difference [13]. As an example, some studies and applications on muscle with imaging techniques could be improved if optical clearing is used [14,15].…”

Diagnosis of rheumatoid arthritis using light: correction of motion artefacts and color visualization of multispectral images

“…The investigations in patients showed significant differences regarding the intensity distributions of the scattered-light images during follow-up after administration of suitable drugs [5,6]. Clinical findings of the examined joints corresponded with the results of the optical diagnosis in more than 80% of all cases.…”

Pseudo colour visualization of fused multispectral laser scattering images for optical diagnosis of rheumatoid arthritis

“…The investigations in patients showed significant differences regarding the intensity distributions of the scattered light images during follow-up after administration of suitable drugs [10,11]. Clinical findings of the examined joints corresponded with the results of the optical diagnosis in more than 80% of all cases.…”

“…For this reason, an optimum algorithm must be found which accentuates and depicts diagnostically essential visual contents. information in contrast to former methods [10,11]. These features are emphasized further by pseudo-coloration.…”