Decorating Porous Aromatic Framework Cavities with Long‐Chain Alkyl Grippers for Rapid and Selective Iron(III) Detection

Abstract

Due to the key role of Fe(III) species in living organisms, realtime detection of Fe 3 + ions is an important topic for the accurate diagnosis of many diseases, such as Alzheimer's, Huntington's, and Parkinson's diseases. Here, soft long-chain alkyl groups serving as the grippers are introduced into the rigid porous skeleton through a one-step Suzuki-coupling reaction. Through the ion-induced dipole interaction of longchain alkyl groups with Fe 3 + ions, the resulting PAF solid exhibits excellent enrichment effect for metal elements.Accordingly, an absorption competition quenching (ACQ) phenomenon is observed leading to the selectivity and sensitivity for monitoring Fe 3 + ions in the presence of various interfering ions. The sensing performance with the detection limit of 5.34 × 10 À 6 M far exceeds that of other porous solids including MOFs, ZIFs, COPs, and PNTs, etc. This work pioneers an efficient strategy that introducing long-chain alkanes as the grippers for the design of advanced sensors for practical application.

Porous organic polymers-based fluorescent chemosensors for Fe(III) ions-a functional mimic of siderophores

“…While being widely used as a fluorescent sensor, pyrene and its derivatives suffer from a decrease in fluorescence quantum yield due to the tight packing of porous solids affects the practical applicability of such sensor ( Feng et al, 2023 ). In their work, the Xia group innovatively introduced long-chain alkanes into a porous aromatic network which resulted in the improvement of the quantum yield to a great extent (0.79% (pure phenyl-based PAF) to 22.98% (long-chain alkane-grafted PAF) ( Yan et al, 2022 ). This porous aromatic framework was used successfully as a fluorescent sensor for Fe(III) with high selectivity, sensitivity, and high quantum yield efficiency.…”

“…(B) Fluorescence sensing of Fe(III) by LNU-22 and LNU-24. Reprinted with permission from ( Yan et al, 2022 ). Copyright 2022 Wiley.…”