Decorin as a possible strategy for the amelioration of COVID-19

Allawadhi, Prince; Singh, Vishal; Khurana, Isha; Rawat, Pushkar Singh; Renushe, Akshata Patangrao; Khurana, Amit; Navik, Umashanker; Allwadhi, Sachin; Karlapudi, Satish Kumar; Banothu, Anil Kumar; Bharani, Kala Kumar

doi:10.1016/j.mehy.2021.110612

Cited by 24 publications

(14 citation statements)

References 63 publications

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“…Natural product bilirubin nanomedicine can inhibit inflammatory response which has potential in anti-COVID-19 40 . Based on our data that Honghua or Xihonghua may target cell adhesion, which may link to extracellular matrix based targeting in nanomedicine 41 . Moreover, carbon dots could also be applied in anti-COVID-19 42 , 43 .…”

Section: Discussionmentioning

confidence: 95%

Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Tilegen

Nazarbek

et al. 2022

Sci Rep

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Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.

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Section: Discussionmentioning

confidence: 95%

Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Tilegen

Nazarbek

et al. 2022

Sci Rep

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“…Progesterone decreases the severity of cytokine storms in COVID-19 patients 40 . In addition to those proposed repurposing drugs, some other highly potential drugs are also worth considering such as Bilirubin 53 and Decorin 54 .…”

Section: Discussionmentioning

confidence: 99%

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence

Hsieh

Wang

Chen

et al. 2021

Sci Rep

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Since the 2019 novel coronavirus disease (COVID-19) outbreak in 2019 and the pandemic continues for more than one year, a vast amount of drug research has been conducted and few of them got FDA approval. Our objective is to prioritize repurposable drugs using a pipeline that systematically integrates the interaction between COVID-19 and drugs, deep graph neural networks, and in vitro/population-based validations. We first collected all available drugs (n = 3635) related to COVID-19 patient treatment through CTDbase. We built a COVID-19 knowledge graph based on the interactions among virus baits, host genes, pathways, drugs, and phenotypes. A deep graph neural network approach was used to derive the candidate drug’s representation based on the biological interactions. We prioritized the candidate drugs using clinical trial history, and then validated them with their genetic profiles, in vitro experimental efficacy, and population-based treatment effect. We highlight the top 22 drugs including Azithromycin, Atorvastatin, Aspirin, Acetaminophen, and Albuterol. We further pinpointed drug combinations that may synergistically target COVID-19. In summary, we demonstrated that the integration of extensive interactions, deep neural networks, and multiple evidence can facilitate the rapid identification of candidate drugs for COVID-19 treatment.

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“…Nanoceria is a rare earth nanoparticle that possesses promising anti-inflammatory properties by inhibition of NFκB and MAPK pathways, which could halt the progression of systemic inflammatory complications in COVID-19 patients [130]. Bilirubin, decorin, and silver nanoparticles are other nanomedicines that act in almost similar ways to nanoceria [131][132][133].…”

Section: Novel and Repurposed Drugsmentioning

confidence: 99%

Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review

Azali

Mohamed

Harun

et al. 2022

Journal of Genetic Engineering and Biotechnology

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Background The baculovirus expression vector system has been developed for expressing a wide range of proteins, including enzymes, glycoproteins, recombinant viruses, and vaccines. The availability of the SARS-CoV-2 genome sequence has enabled the synthesis of SARS-CoV2 proteins in a baculovirus-insect cell platform for various applications. Main body of the abstract The most cloned SARS-CoV-2 protein is the spike protein, which plays a critical role in SARS-CoV-2 infection. It is available in its whole length or as subunits like S1 or the receptor-binding domain (RBD). Non-structural proteins (Nsps), another recombinant SARS-CoV-2 protein generated by the baculovirus expression vector system (BEV), are used in the identification of new medications or the repurposing of existing therapies for the treatment of COVID-19. Non-SARS-CoV-2 proteins generated by BEV for SARS-CoV-2 diagnosis or treatment include moloney murine leukemia virus reverse transcriptase (MMLVRT), angiotensin converting enzyme 2 (ACE2), therapeutic proteins, and recombinant antibodies. The recombinant proteins were modified to boost the yield or to stabilize the protein. Conclusion This review covers the wide application of the recombinant protein produced using the baculovirus expression technology for COVID-19 research. A lot of improvements have been made to produce functional proteins with high yields. However, there is still room for improvement and there are parts of this field of research that have not been investigated yet.

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Decorin as a possible strategy for the amelioration of COVID-19

Cited by 24 publications

References 63 publications

Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Honghua extract mediated potent inhibition of COVID-19 host cell pathways

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence

Application of Baculovirus Expression Vector system (BEV) for COVID-19 diagnostics and therapeutics: a review

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