Decorin in the Tumor Microenvironment

Baghy, Kornélia; Reszegi, Andrea; Tátrai, Péter; Kovalszky, Ilona

doi:10.1007/978-3-030-48457-6_2

Cited by 23 publications

(17 citation statements)

References 176 publications

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“…We assign properties and functions of the identified proteins according to Baghy et al [ 25 , 26 , 27 , 28 ]. In summary, collagen acts as a cell-binding protein that performs an adhesive function by integrating collagen bundles, a major component of the extracellular matrix.…”

Section: Resultsmentioning

confidence: 99%

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

et al. 2022

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Natural biopolymers demonstrate significant bone and connective tissue-engineering application efficiency. However, the quality of the biopolymer directly depends on microstructure and biochemical properties. This study aims to investigate the biocompatibility and microstructural properties of demineralized human spongiosa Lyoplast® (Samara, Russian Federation). The graft’s microstructural and biochemical properties were analyzed by scanning electron microscopy (SEM), micro-computed tomography, Raman spectroscopy, and proteomic analysis. Furthermore, the cell adhesion property of the graft was evaluated using cell cultures and fluorescence microscopy. Microstructural analysis revealed the hierarchical porous structure of the graft with complete removal of the cellular debris and bone marrow components. Moreover, the proteomic analysis confirmed the preservation of collagen and extracellular proteins, stimulating and inhibiting cell adhesion, proliferation, and differentiation. We revealed the adhesion of chondroblast cell cultures in vitro without any evidence of cytotoxicity. According to the study results, demineralized human spongiosa Lyoplast® can be effectively used as the bioactive scaffold for articular hyaline cartilage tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

et al. 2022

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“…Another study confirmed that a Decorin-overexpression could enhance the proliferation of myoblasts and lead to the growth of myotubes [ 74 ]. Within muscle-body-crosstalk, Decorin inhibits angiogenesis and tumorgenesis [ 75 ].…”

Section: Myokinesmentioning

confidence: 99%

Myokines and Resistance Training: A Narrative Review

Zunner

Wachsmuth

Eckstein

et al. 2022

IJMS

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In the last few years, the muscular system has gained attention due to the discovery of the muscle-secretome and its high potency for retaining or regaining health. These cytokines, described as myokines, released by the working muscle, are involved in anti-inflammatory, metabolic and immunological processes. These are able to influence human health in a positive way and are a target of research in metabolic diseases, cancer, neurological diseases, and other non-communicable diseases. Therefore, different types of exercise training were investigated in the last few years to find associations between exercise, myokines and their effects on human health. Particularly, resistance training turned out to be a powerful stimulus to enhance myokine release. As there are different types of resistance training, different myokines are stimulated, depending on the mode of training. This narrative review gives an overview about resistance training and how it can be utilized to stimulate myokine production in order to gain a certain health effect. Finally, the question of why resistance training is an important key regulator in human health will be discussed.

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“…Within the crosstalk between the muscle and the tumor microenvironment, decorin, which is secreted during exercise, has been shown to inhibit angiogenesis, carcinogenesis but also the TGFβ-induced fibrosis, through the interactions with different receptors, such as the epidermal growth factor receptor (EGFR) or insulin-like growth factor 1 receptor (IGF-1R), regulation of cell-cycle associated genes, but also miRNAs [ 312 , 313 , 314 ]. Moreover, its high level is associated with the improved physical function and an increased overall survival (median 732 days vs. 463 days) in hepatocellular carcinoma [ 315 ].…”

Section: Emerging Mechanistic Viewsmentioning

confidence: 99%

Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives

Torregrosa

Chorin

Beltran

et al. 2022

Cancers

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Multidisciplinary supportive care, integrating the dimensions of exercise alongside oncological treatments, is now regarded as a new paradigm to improve patient survival and quality of life. Its impact is important on the factors that control tumor development, such as the immune system, inflammation, tissue perfusion, hypoxia, insulin resistance, metabolism, glucocorticoid levels, and cachexia. An increasing amount of research has been published in the last years on the effects of physical activity within the framework of oncology, marking the appearance of a new medical field, commonly known as “exercise oncology”. This emerging research field is trying to determine the biological mechanisms by which, aerobic exercise affects the incidence of cancer, the progression and/or the appearance of metastases. We propose an overview of the current state of the art physical exercise interventions in the management of cancer patients, including a pragmatic perspective with tips for routine practice. We then develop the emerging mechanistic views about physical exercise and their potential clinical applications. Moving toward a more personalized, integrated, patient-centered, and multidisciplinary management, by trying to understand the different interactions between the cancer and the host, as well as the impact of the disease and the treatments on the different organs, this seems to be the most promising method to improve the care of cancer patients.

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Decorin in the Tumor Microenvironment

Cited by 23 publications

References 176 publications

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

Myokines and Resistance Training: A Narrative Review

Physical Activity as the Best Supportive Care in Cancer: The Clinician’s and the Researcher’s Perspectives

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