Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness

He, Jianghong; Cui, Yue; Song, Ming; Yang, Yi; Dang, Yuanyuan; Jiang, Tianzi; Xu, Ran

doi:10.1111/ane.12299

Cited by 39 publications

(33 citation statements)

References 25 publications

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“…Previous studies have established a functional interaction between the precuneus and thalamus during changes in consciousness [Arthuis et al, 2009;Crone et al, 2015;Hannawi et al, 2015;He et al, 2014;Vanhaudenhuyse et al, 2010;Xie et al, 2011;Zhang and Li, 2012]. Here, we identified a map of structural and functional connectivity between these two regions.…”

Section: Functional Vs Structural Connectivitymentioning

confidence: 89%

Structural and functional connectivity of the precuneus and thalamus to the default mode network

2016

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Neuroimaging studies have identified functional interactions between the thalamus, precuneus, and default mode network (DMN) in studies of consciousness. However, less is known about the structural connectivity of the precuneus and thalamus to regions within the DMN. We used diffusion tensor imaging (DTI) to parcellate the precuneus and thalamus based on their probabilistic white matter connectivity to each other and DMN regions of interest (ROIs) in 37 healthy subjects from the Human Connectome Database. We further assessed resting-state functional connectivity (RSFC) among the precuneus, thalamus, and DMN ROIs. The precuneus was found to have the greatest structural connectivity with the thalamus, where connection fractional anisotropy (FA) increased with age. The precuneus also showed significant structural connectivity to the hippocampus and middle pre-frontal cortex, but minimal connectivity to the angular gyrus and midcingulate cortex. In contrast, the precuneus exhibited significant RSFC with the thalamus and the strongest RSFC with the AG. Significant symmetrical structural connectivity was found between the thalamus and hippocampus, mPFC, sFG, and precuneus that followed known thalamocortical pathways, while thalamic RSFC was strongest with the precuneus and hippocampus. Overall, these findings reveal high levels of structural and functional connectivity linking the thalamus, precuneus, and DMN. Differences between structural and functional connectivity (such as between the precuneus and AG) may be interpreted to reflect dynamic shifts in RSFC for cortical hub-regions involved with consciousness, but could also reflect the limitations of DTI to detect superficial white matter tracts that connect cortico-cortical regions. Hum Brain Mapp 38:938-956, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Functional Vs Structural Connectivitymentioning

confidence: 89%

Structural and functional connectivity of the precuneus and thalamus to the default mode network

2016

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“…By using a seed based analysis approach, our data suggest that the claustrum and MD thalamus are anatomically and functionally connected to mPFC, and thus may be involved in the rodent default mode network. Previous studies in both humans (He et al 2015) and rodents (Sforazzini et al 2014b; Schwarz et al 2013) using seed-based approaches have indicated that thalamus is functionally connected to the default mode network (reviewed in Gozzi and Schwarz 2016). Our data expand on these studies to indicate that the claustrum is also functionally connected to the mPFC, and thus likely to influence the default mode network.…”

Section: Discussionmentioning

confidence: 99%

Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states

et al. 2016

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The claustrum is a brain region whose function remains unknown, though many investigators suggest it plays a role in conscious attention. Resting-state functional magnetic resonance imaging (RS-fMRI) has revealed how anesthesia alters many functional connections in the brain, but the functional role of the claustrum with respect to the awake versus anesthetized states remains unknown. Therefore, we employed a combination of seed-based RS-fMRI and neuroanatomical tracing to reveal how the anatomical connections of the claustrum are related to its functional connectivity during quiet wakefulness and the isoflurane-induced anesthetic state. In awake rats, RS-fMRI indicates that the claustrum has interhemispheric functional connections with the mediodorsal thalamus (MD) and medial prefrontal cortex (mPFC), as well as other known connections with cortical areas that correspond to the connections revealed by neuroanatomical tracing. During deep isoflurane anesthesia, the functional connections of the claustrum with mPFC and MD were significantly attenuated, while those with the rest of cortex were not significantly altered. These changes in claustral functional connectivity were also observed when seeds were placed in mPFC or MD during RS-fMRI comparisons of the awake and deeply anesthetized states. Collectively, these data indicate that the claustrum has functional connections with mPFC and MD-thalamus that are significantly lessened by anesthesia.

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“…Thalamo-DMN connectivity has been shown to be altered in numerous patient populations including reduced connectivity in patients with disordered consciousness (He et al, 2014), but increased connectivity in individuals with depression (Greicius et al, 2007) and PTSD (Yin et al, 2011). Furthermore chronic pain patients, greater connectivity between the thalamus and DMN was found to be associated with increased pain rumination (Kucyi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury

Sours

George

Zhuo

et al. 2015

Brain Imaging and Behavior

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The thalamo-cortical resting state functional connectivity of 7 sub-thalamic regions were examined in a prospectively recruited population of 77 acute mild TBI (mTBI) patients within the first 10 days (mean 6±3 days) of injury and 35 neurologically intact control subjects using the Oxford thalamic connectivity atlas. Neuropsychological assessments were conducted using the Automated Neuropsychological Assessment Metrics (ANAM). A subset of participants received a magentic resonance spectroscopy (MRS) exam to determine metabolite concentrations in the thalamus and posterior cingulate cortex. Results show that patients performed worse than the control group on various subtests of ANAM and the weighted throughput score, suggesting reduced cognitive performance at this early stage of injury. Both voxel and region of interest based analysis of the resting state fMRI data demonstrated that acute mTBI patients have increased functional connectivity between the various sub-thalamic regions and cortical regions associated with sensory processing and the default mode network (DMN). In addition, a significant reduction in NAA/Cr was observed in the thalamus in the mTBI patients. Furthermore, an increase in Cho/Cr ratio specific to mTBI patients with self-reported sensory symptoms was observed compared to those without self-reported sensory symptoms. These results provide novel insights into the neural mechanisms of the brain state related to internal rumination and arousal, which have implications for new interventions for mTBI patients with persistent symptoms. Furthermore, an understanding of heightened sensitivity to sensory related inputs during early stages of injury may facilitate enhanced prediction of safe return to work.

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Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness

Abstract: Our results suggest that functional connections between the mediodorsal thalamus and the DMN may play important roles in the pathogenesis of DOC.

Cited by 39 publications

References 25 publications

Structural and functional connectivity of the precuneus and thalamus to the default mode network

Structural and functional connectivity of the precuneus and thalamus to the default mode network

Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states

Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury

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