2010
DOI: 10.1053/j.ajkd.2009.12.028
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Decreased Kidney Function and Crystal Deposition in the Tubules After Kidney Transplant

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Cited by 29 publications
(33 citation statements)
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“…2,10 With vigorous treatment, even improvement of allograft dysfunction may be achieved. 10,11 Asymptomatic individuals likely benefit from the same treatment. 12 It is not known if individuals with APRT deficiency on dialysis benefit from allopurinol therapy, but all individuals undergoing renal transplantation require treatment with allopurinol.…”
Section: Discussionmentioning
confidence: 99%
“…2,10 With vigorous treatment, even improvement of allograft dysfunction may be achieved. 10,11 Asymptomatic individuals likely benefit from the same treatment. 12 It is not known if individuals with APRT deficiency on dialysis benefit from allopurinol therapy, but all individuals undergoing renal transplantation require treatment with allopurinol.…”
Section: Discussionmentioning
confidence: 99%
“…In some catastrophic situations, APRT remains unrecognized and untreated after ESRD has occurred, allowing DHA nephropathy to recur after renal transplantation, which often leads to irremediable loss of allograft function within a few weeks, unless adequate therapy is rapidly implemented (5,8,(34)(35)(36).…”
Section: Clinical Presentationmentioning
confidence: 99%
“…Several other cases of crystalline nephropathy recurring after renal transplantation and leading to irremediable loss of allograft function within a few weeks have been reported [6,[8][9][10]26,27]. In most tragic cases, several renal transplantations failed before APRT deficiency was properly recognized and treated [8,10].…”
Section: Number Of Families 56mentioning
confidence: 99%
“…Recent reports highlight the risk of renal allograft loss in patients with undiagnosed APRT deficiency [8][9][10][11] and the need for improved early detection of the disease. Early diagnosis of APRT deficiency is critical because patients may develop chronic kidney disease (CKD) and in some case irreversible kidney failure that may have been efficiently prevented by allopurinol, a XDH inhibitor (Figure 1).…”
Section: Introductionmentioning
confidence: 99%
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