Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and Alzheimer's disease

Wang, Ruitao; Jin, Di; Li, Ying; Liang, Qi

doi:10.1016/j.jpsychires.2013.01.014

Cited by 52 publications

(41 citation statements)

References 47 publications

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“…However, there are conflicting results about MPV in AD patients. Wang et al reported decreased MPV level, but Yesil et al reported increased MPV level in AD [32, 33]. It is well known that high MPV associates with low-grade inflammatory conditions [34].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

Koçer

Yaman

Niftaliyev

et al. 2013

Current Gerontology and Geriatrics Research

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Platelets induce chronic inflammation which is a key step in atherosclerosis and may be involved in the progression of neurodegenerative diseases (NDD). We aimed to measure the mean platelet volume (MPV) and platelet count (PLC) in NDD patients. The present study was designed to investigate the platelet function by measuring MPV and PLC in NDD. A total of 182 outpatients with Alzheimer's (AD) or Parkinson's diseases (PD) were included. The control group consisted of 104 healthy subjects. Platelet count was similar between groups. MPV values of PD patients were higher than those of AD patients and controls (P < 0.001). MPV correlated negatively with Heohn and Yahr scale (HYS) score (P < 0.001). Increased MPV in patients with PD may point to a platelet dysfunction. High-grade inflammation presents with low levels of MPV as seen in PD patients with high HYS scores.

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Section: Discussionmentioning

confidence: 99%

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

Koçer

Yaman

Niftaliyev

et al. 2013

Current Gerontology and Geriatrics Research

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“…6 Moreover, platelets release more than 90% of circulating amyloid precursor protein (APP), which has been regarded as a diagnostic biomarker for AD. 13,14 The idea that AD is treated through the inhibition of pathologically excessive release of Aβ by platelets was suggested as an alternative therapeutic strategy. [10][11][12] Our previous reports confirmed that activated platelets, measured by mean platelet volume and platelet distribution width, are positively correlated with Mini-Mental State Examination (MMSE) score and have the potential to be used to differentiate between distinct dementia subtypes.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] Our previous reports confirmed that activated platelets, measured by mean platelet volume and platelet distribution width, are positively correlated with Mini-Mental State Examination (MMSE) score and have the potential to be used to differentiate between distinct dementia subtypes. 13,14 The idea that AD is treated through the inhibition of pathologically excessive release of Aβ by platelets was suggested as an alternative therapeutic strategy. 15 C-type lectin-like receptor 2 (CLEC-2), which belongs to a c-type lectin super family, is a receptor on the platelet surface and binds to a sialoglycoprotein, podoplanin.…”

Section: Introductionmentioning

confidence: 99%

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

et al. 2019

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Objective: Increased permeability and changes in gut microbiota contributed to the pathogenesis of Alzheimer's disease (AD). Zonulin is a key modulator that regulates intestinal barrier function. Peripheral platelet alterations have been involved in AD pathology. C-type lectin-like receptor 2 (CLEC-2) is a receptor on the platelet surface for activation. The purpose of this study was to determine zonulin and CLEC-2 levels in mild cognitive impairment (MCI) and AD, and investigate the relationship between zonulin and CLEC-2. Methods:In this study, CLEC-2 and zonulin levels were measured using ELISA assay in 110 AD patients, 110 MCI patients, and 110 non-demented control subjects.Results: Increased CLEC-2 and zonulin levels were observed in MCI and AD patients. Furthermore, AD patients had higher CLEC-2 and zonulin levels compared with MCI patients. In addition, CLEC-2 levels were positively correlated with zonulin levels, after adjusting confounding factors (r = .592, P < .001). Multivariate analysis revealed that increased CLEC-2 and zonulin levels were significantly associated with reduced Mini-Mental State Examination (MMSE) score.Conclusions: C-type lectin-like receptor 2 is correlated with zonulin after adjusting confounding covariates. Moreover, increased CLEC-2 and zonulin are the significant factors for reduced MMSE score in MCI and AD. Further studies are needed. K E Y W O R D SAlzheimer's disease, C-type lectin-like receptor 2, mild cognitive impairment, zonulin

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“…Elevated MPV was indicated as an independent risk factor for myocardial infarction and CVE, while a low MPV value was shown to be associated with the activity of inflammatory rheumatologic diseases. [25][26][27] In a study comparing patients with AD and mild cognitive impairment to patients 13 reported that neuroinflammation caused by abnormal thrombocyte activation was the major underlying reason of these diseases. They found that patients with AD had lower MPV and PDW levels than those of the patients with mild cognitive impairment and without cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 On the other hand, to the best of our knowledge, there is no study investigating the alterations of these parameters in patients with CRPS. Accordingly, in this study, we aimed to compare the levels of platelet and erythrocyte indexes including MPV, PDW, and RDW values between CRPS type I patients and healthy controls to establish a marker of neuroinflammation that might be a potential factor involved in CRPS etiopathogenesis.…”

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confidence: 99%

Platelet and Erythrocyte Indexes in Complex Regional Pain Syndrome Type I

et al. 2016

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Objectives:This study aims to compare the levels of platelet and erythrocyte indexes including mean platelet volume, platelet distribution width (PDW), and red blood cell distribution (RDW) values between complex regional pain syndrome (CRPS) type I patients and healthy controls to establish a marker of neuroinflammation that might be a potential factor involved in CRPS etiopathogenesis. Patients and methods: A total of 21 patients (14 males, 7 females; mean age 35.0±15.4 years; range 15 to 69 years) with a diagnosis of CRPS type I and 44 age-and sex-similar healthy controls (29 males, 15 females; mean age 35.8±8.5 years; range 16 to 53 years) were included in this study. Mean platelet volume, PDW, RDW, white blood count, hemoglobin, erythrocyte sedimentation rate, and C-reactive protein levels, and neutrophil to lymphocyte ratio and thrombocyte to lymphocyte ratio were compared between the patient and control groups. Results: No differences were noted between patient and control groups in terms of erythrocyte sedimentation rate and C-reactive protein levels, white blood cell, neutrophil, lymphocyte and thrombocyte counts, and neutrophil to lymphocyte and thrombocyte to lymphocyte ratios (all p>0.05). When compared with controls, patients had significantly higher mean corpuscular volume (p=0.019) and RDW (p=0.002) values, and a lower PDW level (p=0.006). Conclusion: Differences in PDW, RDW, and mean corpuscular volume values between patients and controls might support the potential role of neuroinflammation in the etiopathogenesis of CRPS type I. Prospective studies with larger sample sizes are warranted in the early detection and differential diagnosis of CRPS type I.

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Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and Alzheimer's disease

Cited by 52 publications

References 47 publications

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

Platelet and Erythrocyte Indexes in Complex Regional Pain Syndrome Type I

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