Decreased photoreceptor inner segment/outer segment junction reflectivity in patients with idiopathic epimacular membrane

Toprak, İ̇brahim; Yaylalı, Volkan; Yıldırım, Cem

doi:10.1038/eye.2014.147

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…Hood et al [20] showed that decreased cone function was correlated with the intensity of the inner segment ellipsoid (ISe) band. With this, Yılmaz Tugan et al [21] and Toprak et al [22] determined that the reflectivities of the EZ (formerly known as IS/OS) may be related to prognosis in patients with macular hole and epiretinal membrane. For these reasons, the reflectivities of these structures reflect their functions.…”

Section: Discussionmentioning

confidence: 99%

Decreased peri-parafoveal RPE, EZ and ELM intensity: A novel predictive biomarker for hydroxychloroquine retinal toxicity

Yucel Gencoglu,

Ağın,

Colak

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate the reflectivities of the retinal pigment epithelium (RPE), ellipsoid zone (EZ), and external limiting membrane (ELM) in the central fovea, perifoveal, and parafoveal regions with Optical Coherence Tomography (OCT) and the change in choroid vascular index (CVI) in patients using hydroxychloroquine (HCQ). Methods Sixty-one patients underwent HCQ treatment; age and sex-matched 44 control group subjects were included in the study. The RPE, EZ, and ELM reflectivities were measured with the ImageJ program at 5 points, and CVI was calculated. Results RPE, EZ, and ELM reflectivities in the central fovea were higher in the HCQ group than in the control group (p < 0.001, p = 0.013, p = 0.022). In the HCQ group, there was a decrease in RPE reflectivities in the temporal, nasal parafovea, and nasal perifovea (p = 0.001, p = 0.03, p = < 0.001). EZ and ELM reflectivity in the nasal parafovea and nasal perifovea was lower in the patient group than in the control group (p = 0.007, p = 0.005, p = 0.009, p = 0.001). In the HCQ group, all absolute para and perifoveal reflectivities relative to the fovea decreased significantly more than in the control group (p < 0.05). Conclusion In patients who underwent HCQ treatment, there is a decrease in the reflectivities of the para and perifoveal RPE, EZ, and ELM compared to the fovea. This decrease is more pronounced than the decrease in reflectivity in the para and perifoveal regions compared to the fovea in people who do not use HCQ. This situation can be considered as a sign of toxicity that is a precursor to overt maculopathy.

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Section: Discussionmentioning

confidence: 99%

Decreased peri-parafoveal RPE, EZ and ELM intensity: A novel predictive biomarker for hydroxychloroquine retinal toxicity

Yucel Gencoglu,

Ağın,

Colak

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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“…with ectopic inner foveal layers) with, respectively, one and one error for the SS-OCT and three and five errors for the PCI device (p = 0.02) (Figs 2 and 3 ). These findings resulted in a clinically relevant difference in terms of refractive PE, that would have brought to a significantly greater mean myopic shift of 0.69 D with the PCI compared to 0.24 D for the SS-OCT device (p<0.05).The cause of AL measurement errors in patients with severe ERM could be related to: (1) a thick ERM / posterior hyaloid (that being highly reflective accentuate the vitreo-retinal interface), (2) the attenuation of the RPE reflectivity caused by the ERM itself, and (3) by a thicker retina and the presence of ectopic inner foveal layers [ 8 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Swept-source OCT reduces the risk of axial length measurement errors in eyes with cataract and epiretinal membranes

et al. 2021

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Aims To compare the biometric data from partial coherence interferometry (PCI) and swept-source OCT (SS-OCT) in patients with age-related cataract and epiretinal membrane (ERM): ERM, ERM with foveoschisis and macular pseudohole. Methods 49 eyes of 49 subjects including 36 ERM, 9 ERM foveoschisis and 4 macular pseudohole were analysed to evaluate the axial length (AL) measurements and the presence of AL measurement errors, defined basing on the shape of the biometric output graphs and on the concordance of AL values between instruments. Eyes with ERM were divided in four stages according to OCT features (i.e. presence/absence of the foveal pit, presence of ectopic inner foveal layers, disrupted retinal layers). Results The devices provided similar mean AL measurements in all subgroups, with differences <0.1 mm in 41/49 cases (83.6%). AL measurement errors were observed in ERM stages 3 and 4, characterized by ectopic inner foveal layers, and were significantly more frequent with the PCI (8/17, 47%) as compared with the SS-OCT device (2/17, 12%), p = 0.02. The refractive prediction error in cases with AL measurement errors was significantly greater using the PCI compared to the SS-OCT device (p<0.05). Conclusion Both devices provide reliable biometric data in the majority of patients and can be used in the preoperative assessment of patients with age-related cataract and ERM. In eyes with ectopic inner foveal layers, attention should be paid as AL measurement and refractive prediction errors may occur, more frequently with the PCI device.

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“…Reflectance profiles were taken in an automated fashion using a customized script including plot profile extraction in Fiji. This approach has been described elsewhere as a robust method to access EZ integrity [ 11 , 19 , 20 ]. Manual adjustment was not applied.…”

Section: Methodsmentioning

confidence: 99%

“…However, the long-term outcome of EZR during anti-VEGF treatment remains unknown. Additionally, in several studies, the quantitative analysis of EZR was laborious and time consuming as the measurements were manually obtained and mostly at a limited number of regions of interest [ 16 , 19 , 20 ]. The aim of this study is to evaluate the ellipsoid zone outcome (EZR and EZ-RPE distance) during a 3- to 5-year follow-up of DME patients under anti-VEGF therapy and to find potential correlation with the visual acuity outcome beyond 1 year after treatment initiation.…”

Section: Introductionmentioning

confidence: 99%

Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study

Kessler

Bagautdinov

Khoramnia

2021

Journal of Diabetes Research

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Purpose. Ellipsoid zone (EZ) integrity is identified as a potential biomarker for therapy surveillance and outcome prediction of visual acuity (VA). However, only a few studies report long-term results of over 1 year of clinical and anatomical changes in patients with diabetic macular edema (DME). This study is aimed at describing the long-term VA and anatomical outcomes in spectral domain optical coherence tomography (OCT) (relative ellipsoid zone reflectivity ratio, central macular thickness, and volume) in patients with DME treated with antivascular endothelial growth factor (anti-VEGF) therapy. Furthermore, we studied the correlation between EZ integrity and changes in visual acuity. Methods. 71 eyes of 71 patients were included in this retrospective study. Clinical characteristics were reviewed yearly. OCT data were assessed at baseline and after 1, 3, and 5 years. EZ parameters were quantified automatically. OCT parameters and visual outcome were correlated and analyzed in multivariable regression models. Results. EZ reflectivity ratio correlated with functional outcome in DME patients from baseline to fifth year at all time points (for all p < 0.05 ). EZ reflectivity improved the most in the first year of treatment (0.68 to 0.75; p < 0.05 ) and declined gradually until year 5 of therapy (0.71; compared to baseline p > 0.05 ). Similarly, best VA was achieved after 1 year (0.40 logarithm of the minimum angle of resolution (logMAR) to 0.28 logMAR; p < 0.001 ) and declined gradually until year 5. Final VA in year 5 was comparable to baseline (0.45 logMAR, compared to baseline p > 0.05 ). Together with baseline VA, baseline EZ parameters did predict VA outcome after 1 year ( p < 0.05 ). Concordantly, VA and EZ parameters from year 1 were associated with VA outcome in year 2. Conclusion. This study described the long-term course of EZ changes during anti-VEGF treatment in DME patients. In addition, our results underlined the potential of EZ parameters as novel OCT biomarkers for prediction of VA outcomes during therapy.

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Decreased photoreceptor inner segment/outer segment junction reflectivity in patients with idiopathic epimacular membrane

Cited by 10 publications

References 21 publications

Decreased peri-parafoveal RPE, EZ and ELM intensity: A novel predictive biomarker for hydroxychloroquine retinal toxicity

Decreased peri-parafoveal RPE, EZ and ELM intensity: A novel predictive biomarker for hydroxychloroquine retinal toxicity

Swept-source OCT reduces the risk of axial length measurement errors in eyes with cataract and epiretinal membranes

Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study

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