Decreased resting-state alpha peak frequency in children and adolescents with fetal alcohol spectrum disorders or prenatal alcohol exposure

Candelaria‐Cook, Felicha T.; Flynn, Lucinda; Cerros, Cassandra; Kodituwakku, Piyadasa; Bakhireva, Ludmila N.; Hill, Dina E.; Stephen, Julia M.

doi:10.1016/j.dcn.2022.101137

Cited by 5 publications

(5 citation statements)

References 74 publications

(119 reference statements)

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“…In our study, middle and higher SES children had greater right-lateralized frontal alpha activity than low SES children, but these differences did not reach statistical significance. We also did not find an association between SES and another reliable measure of cortical maturation, alpha peak frequency, consistent with prior literature ( Candelaria-Cook et al, 2022 ). SES is a broad indicator of many genetic and environmental factors that can influence brain development, such as nutrition, trauma, learning disorders, and exposure to language and reading.…”

Section: Discussionsupporting

confidence: 92%

Resting EEG correlates of neurodevelopment in a socioeconomically and linguistically diverse sample of toddlers: Wave 1 of the Kia Tīmata Pai best start New Zealand study

Arnett,

Guiney,

Bakir-Demir

et al. 2024

Developmental Cognitive Neuroscience

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Section: Discussionsupporting

confidence: 92%

Resting EEG correlates of neurodevelopment in a socioeconomically and linguistically diverse sample of toddlers: Wave 1 of the Kia Tīmata Pai best start New Zealand study

Arnett,

Guiney,

Bakir-Demir

et al. 2024

Developmental Cognitive Neuroscience

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“…TDC did not have known prenatal exposure to alcohol or other substances; nor did they have histories of developmental delays or neurological or psychological problems. For the present study, data were pooled from 2 separate studies with similar exclusion and inclusion criteria (Candelaria‐Cook et al, 2021; Candelaria‐Cook, Schendel, et al, 2022; Stephen et al, 2021). For data to be included in the current analysis, participants with 1 min of continuous movement‐free, artifact‐free data were included.…”

Section: Methodsmentioning

confidence: 99%

“…Interhemispheric connectivity has also been found to be impaired in children with PAE (Wozniak et al, 2011), along with an overall reduction in path length and global efficiency (Wozniak et al, 2013). Other evidence of altered local dynamics is the increased entropy in the right hemisphere of children with FAS (Candelaria‐Cook et al, 2021) and significantly reduced alpha peak frequency in children and adolescents with PAE/FASD (Candelaria‐Cook, Schendel, et al, 2022). While differences in sFNC are important to highlight, group differences in dynamic functional network connectivity (dFNC) have not yet been studied.…”

Section: Introductionmentioning

confidence: 99%

Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders

Candelaria‐Cook

Flynn

Cerros

et al. 2023

Alcohol: Clinical and Experimental Research

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Background: Prenatal alcohol exposure (PAE) can result in harmful and long-lasting neurodevelopmental changes. Children with PAE or a fetal alcohol spectrum disorder (FASD) have decreased white matter volume and resting-state spectral power compared to typically developing controls (TDC) and impaired resting-state static functional connectivity. The impact of PAE on resting-state dynamic functional network connectivity (dFNC) is unknown. Methods: Using eyes-closed and eyes-open magnetoencephalography (MEG) restingstate data, global dFNC statistics and meta-states were examined in 89 children aged 6-16 years (51 TDC, 38 with FASD). Source analyzed MEG data were used as input to group spatial independent component analysis to derive functional networks from which the dFNC was calculated. Results: During eyes-closed, relative to TDC, participants with FASD spent a significantly longer time in state 2, typified by anticorrelation (i.e., decreased connectivity) within and between default mode network (DMN) and visual network (VN), and state 4, typified by stronger internetwork correlation. The FASD group exhibited greater dynamic fluidity and dynamic range (i.e., entered more states, changed from one meta-state to another more often, and traveled greater distances) than TDC. During eyes-open, TDC spent significantly more time in state 1, typified by positive intra-and interdomain connectivity with modest correlation within the frontal network (FN), while participants with FASD spent a larger fraction of time in state 2, typified by anticorrelation within and between DMN and VN and strong correlation within and between FN, attention network, and sensorimotor network. Conclusions: There are important resting-state dFNC differences between children with FASD and TDC. Participants with FASD exhibited greater dynamic fluidity and dynamic range and spent more time in states typified by anticorrelation within and between DMN and VN, and more time in a state typified by high internetwork connectivity. Taken together, these network aberrations indicate that prenatal alcohol exposure has a global effect on resting-state connectivity.

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“…There has been a growing interest in the use of MEG to assess the spontaneous cortical oscillations, with intentions of identifying clinically relevant biomarkers ( 28 , 30 , 52 , 53 ). Prior experimental work has shown that MEG assessments of the spontaneous relative power of the respective frequency bands are reliable within the week and across several years ( 54 , 55 ).…”

Section: Discussionmentioning

confidence: 99%

Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy

et al. 2023

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IntroductionCerebral Palsy (CP) is the most common neurodevelopmental motor disability, resulting in life-long sensory, perception and motor impairments. Moreover, these impairments appear to drastically worsen as the population with CP transitions from adolescents to adulthood, although the underlying neurophysiological mechanisms remain poorly understood.MethodsWe began to address this knowledge gap by utilizing magnetoencephalographic (MEG) brain imaging to study how the amplitude of spontaneous cortical activity (i.e., resting state) is altered during this transition period in a cohort of 38 individuals with spastic diplegic CP (Age range = 9.80–47.50 years, 20 females) and 67 neurotypical controls (NT) (Age range = 9.08–49.40 years, Females = 27). MEG data from a five-minute eyes closed resting-state paradigm were source imaged, and the power within the delta (2–4 Hz), theta (5–7 Hz), alpha (8–12 Hz), beta (15–29 Hz), and gamma (30–59 Hz) frequency bands were computed.ResultsFor both groups, the delta and theta spontaneous power decreased in the bilateral temporoparietal and superior parietal regions with age, while alpha, beta, and gamma band spontaneous power increased in temporoparietal, frontoparietal and premotor regions with age. We also found a significant group x age interaction, such that participants with CP demonstrated significantly less age-related increases in the spontaneous beta activity in the bilateral sensorimotor cortices compared to NT controls.DiscussionOverall, these results demonstrate that the spontaneous neural activity in individuals with CP has an altered trajectory when transitioning from adolescents to adulthood. We suggest that these differences in spontaneous cortical activity may play a critical role in the aberrant motor actions seen in this patient group, and may provide a neurophysiological marker for assessing the effectiveness of current treatment strategies that are directed at improving the mobility and sensorimotor impairments seen in individuals with CP.

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Decreased resting-state alpha peak frequency in children and adolescents with fetal alcohol spectrum disorders or prenatal alcohol exposure

Cited by 5 publications

References 74 publications

Resting EEG correlates of neurodevelopment in a socioeconomically and linguistically diverse sample of toddlers: Wave 1 of the Kia Tīmata Pai best start New Zealand study

Resting EEG correlates of neurodevelopment in a socioeconomically and linguistically diverse sample of toddlers: Wave 1 of the Kia Tīmata Pai best start New Zealand study

Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders

Aberrant age-related alterations in spontaneous cortical activity in participants with cerebral palsy

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