Decreased Resting-State Functional Complexity in Elderly with Subjective Cognitive Decline

Ni, Huangjing; Song, Zijie; Liu, Liang; Xing, Qiaowen; Jiang, Qin; Wu, Xuedong

doi:10.3390/e23121591

Cited by 6 publications

(1 citation statement)

References 52 publications

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“…These brain regions with altered activity intensity were primarily associated with the executive (SFG&CPL), language (IPL&CPL), and motor (SFG&IPL) functions. Previous studies have indicated that sALFF increased in the SFG region for CSVD patients (Dong et al, 2021;Ni et al, 2021;Pelkmans et al, 2019;Pena et al, 2019;Ren et al, 2023;Su, Wang et al, 2019;Wang et al, 2015), consistent with our findings. SFG is a core brain region for executing many cognitive tasks and motor control (Li et al, 2013;Wang et al, 2019).…”

Section: F I G U R E 4 Results Of the Relationship Between Dynamic Am...supporting

confidence: 93%

Aberrant spontaneous static and dynamic amplitude of low‐frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment

Zhang,

Wang,

Zheng

et al. 2023

Brain and Behavior

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BackgroundCerebral small vessel disease (CSVD) is considered an age‐related degenerative neurological disorder and the most common risk factor for vascular cognitive impairment (VCI). The amplitude of fluctuation of low frequency (ALFF) can detect altered intrinsic brain activity in CSVD. This study explored the static and dynamic ALFFs in the early stage of CSVD with (CSVD‐M) or without (CSVD‐W) mild cognitive impairment (MCI) in these patients and how these changes contribute to cognitive deterioration.MethodsThirty consecutive CSVD cases and 18 healthy controls (HC) were included in this study. All the participants underwent a 3D magnetization‐prepared rapid gradient‐echo (MPRAGE) sequence to obtain structural T1‐weighted images. Simultaneous multislice imaging 5(SMS5) was used for resting‐state functional MRI (rs‐fMRI), and Data Processing and Analysis of Brain Imaging software helped determine static ALFF (sALFF). The dynamic ALFF (dALFF) was calculated using the sliding window method of DynamicBC software. Analysis of Covariance (ANCOVA) and two‐sample t‐test were used to evaluate the sALFF and temporal variability of dALFF among the three groups. The subjects were rated on a broad standard neuropsychological scale. Partial correlation analysis was used to evaluate the correlation between sALFF and dALFF variability and cognition (Bonferroni correction, statistical threshold set at p < .05).ResultsCompared with HCs, the CSVD‐M group indicated decreased sALFF values in the bilateral cerebellum posterior lobe (CPL) and the left inferior Parietal Lobule (IPL), with increased sALFF values in the right SFG. For dALFF analysis, the CSVD‐W group had significant dALFF variability in the right fusiform gyrus compared with HC. Moreover, the postcentral gyrus (PoCG) was significantly high in the CSVD‐W group. While in the CSVD‐M group, the bilateral paracentral lobules (PL) revealed significantly elevated dALFF variability and low dALFF variability in the left CPL and right IPL compared with HCs. The CSVD‐M group had high dALFF variability in the bilateral PL but low dALFF variability in the left middle temporal gyrus (MTG) and right PoCG compared with the CSVD‐W group. The partial correlation analysis indicated that dALFF variability in the left MTG was positively associated with EM (r = 0.713, p = .002) in CSVD‐W and CSVD‐M groups. In the groups with CSVD‐M and HC, altered dALFF variability in the bilateral PL was negatively correlated with EM (r = −0.560, p = .002).ConclusionThere were significant changes in sALFF and dALFF variability in CSVD patients. Abnormal spontaneous static and dynamic ALFFs may provide new insights into cognitive dysfunction in CSVD with MCI and may be valuable biomarkers for early diagnosis.

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Section: F I G U R E 4 Results Of the Relationship Between Dynamic Am...supporting

confidence: 93%

Aberrant spontaneous static and dynamic amplitude of low‐frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment

Zhang,

Wang,

Zheng

et al. 2023

Brain and Behavior

View full text Add to dashboard Cite

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Disrupted morphological brain network organization in subjective cognitive decline and mild cognitive impairment

Chen,

Liang,

Wei

et al. 2023

Brain Imaging and Behavior

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We aim to investigate the underlying neuropathological mechanisms of alternations in gray matter for subjective cognitive decline (SCD) and mild cognitive impairment (MCI) from the perspective of the human connectome. High-resolution T1-weighted images were acquired from 54 SCD patients, 95 MCI, and 65 healthy controls (HC). Morphological brain networks (MBN) were constructed using similarities in the distribution of grey matter volumes between regions. Structural connectivity strength and topographic metrics were compared, and the relationship to disease severity was assessed. We found signi cantly decreased structural connectivity strength of MBN between the SMN and VAN subnetworks was observed for SCD. The graph-theoretic analysis illustrated disruptions in the whole network organization, where the normalized shortest path increased and the global e ciency decreased in the MCI group compared to the SCD group. In addition, Montreal Cognitive Assessment scores of SCD patients had a signi cantly negative correlation with global e ciency. In summary, the SCD and MCI groups showed different patterns of disruptions in the morphological grey matter network. The present study could provide new sight into the mechanism of AD in terms of MBN.

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Dynamic brain entropy predicts risky decision-making across transdiagnostic dimensions of psychopathology

Ji,

Chen,

et al. 2025

Behavioural Brain Research

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Decreased Resting-State Functional Complexity in Elderly with Subjective Cognitive Decline

Cited by 6 publications

References 52 publications

Aberrant spontaneous static and dynamic amplitude of low‐frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment

Aberrant spontaneous static and dynamic amplitude of low‐frequency fluctuations in cerebral small vessel disease with or without mild cognitive impairment

Disrupted morphological brain network organization in subjective cognitive decline and mild cognitive impairment

Dynamic brain entropy predicts risky decision-making across transdiagnostic dimensions of psychopathology

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