Decreasing Free Radicals Level on High Risk Person After Vitamin C and E Supplement Treatment

Sitorus, Marshall; Anggraini, Dwi Rita; Hidayat,

doi:10.1088/1757-899x/180/1/012093

Cited by 7 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GSH-Px and SOD are important enzymes of the antioxidant system, and their activities are directly proportional to the body's ability to fight against free radicals [ 28 ]. MDA is a product of lipid peroxidation in cell membranes, and its concentrations can indirectly reflect the degree of oxidative tissue damage [ 29 ]. T-AOC indicates the overall level of enzymes and nonenzymatic antioxidants in the body [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Paper Mulberry (Broussonetia papyrifera) Leaf Extract on Growth Performance and Fecal Microflora of Weaned Piglets

Chen

Shui

Chai

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

The paper mulberry (Broussonetia papyrifera) leaf is rich in alkaloids and flavonoids, which has high medicinal and feeding value. We aimed to analyze the effects of B. papyrifera leaf extract on growth performance, antioxidant capacity, immune functions, and fecal microflora of weaned piglets. Thirty healthy, 28-day-old piglets were randomly assigned to three groups and fed with a basal diet supplemented with 0, 150, and 300 g/t B. papyrifera leaf extract for 42 days (control group, group I, and group II) separately. The result revealed that the final weight of piglets in group II was higher than the other groups, and the diarrhea rate in this group was 62.9% lower than in the control group. The feed conversion ratio in group I was significantly lower than the other two groups. Higher blood urine nitrogen concentration was noted in group II, higher glutathione peroxidase and catalase in group II, higher superoxide dismutase in the control group, and higher immune globulins (Ig) IgG, IgA, and IgM in group II. There was no significant difference in community richness and community diversity among the three groups of fecal samples. The relative level of Roseburia was higher in groups I and II, while Lactobacillus was higher in the control group. In conclusion, supplementation with B. papyrifera leaf extract at a certain dosage can increase growth performance and antioxidant capacity of weaned piglets, reduce the occurrence of diarrhea, enhance immune functions and disease resistance, and affect the composition of fecal microflora.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Paper Mulberry (Broussonetia papyrifera) Leaf Extract on Growth Performance and Fecal Microflora of Weaned Piglets

Chen

Shui

Chai

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…MDA level is generally and widely used as a marker of oxidative stress [6]. In vivo and reactive oxygen species (ROS) were suppressed by antioxidant enzymes activity, vitamins C and E [7], [8]. Superoxide dismutase (SOD) is an antioxidant enzyme that is important to inhibit oxidative stress that plays a role in converting free radicals to superoxide anion (O2-).…”

Section: Introductionmentioning

confidence: 99%

Biomarker of Oxidative Stress in Premature Hair Graying at Young Age

Anggraini

Feriyawati

Sitorus

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Gray hair is a physiological process of aging that occurs in everyone. Premature hair graying (PHG) is the term when early hair gray at an unusual age. The causes of PHG are multifactorial, genetic, nutritional, and environmental, including oxidative stress. Free radicals caused interference with cellular responses that cause direct damage to various proteins and DNA in the long term. The body’s defense mechanisms likely antioxidant enzymes, including catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD) was activated against free radicals. AIM: We aimed to evaluate markers of oxidative stress and associated with severe graying at young age. MATERIALS AND METHODS: We recruited consecutive 40 respondents with PHG and healthy controls, male sex and aged <25 years. The severe graying was graded with total of gray hair. The serum samples were collected to detect oxidative stress markers through malondialdehyde (MDA), SOD, catalase, and GPx measurement with enzyme-linked immunosorbent assay. RESULTS: Serum MDA concentration was higher but not significantly (p > 0.05), while serum SOD, catalase, and GPx level, indicators of antioxidant were significantly lower (p < 0.001, p = 0.017 and p < 0.001, respectively) in PHG compared to controls. The correlation between oxidative stress and graying severity was not significant (p > 0.05), but the association between onset and severity of graying was significant (p < 0.001). CONCLUSIONS: Respondents with PHG had increased of pro-oxidants and decreased of antioxidants compared than controls. The severity of graying is equivalent to the level of oxidative stress. The supplement of antioxidants is likely recommended in PHG.

show abstract

“…Heavy air pollution from motor vehicle fumes and cigarettes can increase the formation of free radicals in the body. Free radicals give impact on the pathogenesis of several diseases in humans due to the occurrence of oxidative cell stress (Sitorus et al, 2017). Under normal circumstances, radicals in the body will be eliminated by the body's natural defence mechanism.…”

Section: Introductionmentioning

confidence: 99%

ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC, AND FLAVONOID CONTENTS OF THE EXTRACT OF ENDOPHYTIC FUNGI DERIVED FROM TURMERIC (Curcuma longa) LEAVES

Septiana¹,

Rahmawati²,

Izzati³

et al. 2020

J.Pharm.Sci.Community

View full text Add to dashboard Cite

Air pollution can increase free radicals that may worsen some diseases. Antioxidants such as phenol and flavonoid compounds are known to counteract these free radicals. Long term use of synthetic antioxidants is known to cause bad effects on the body. Therefore, the necessity to search for natural antioxidants from plants and its endophytic microbes continues with the hope to obtain potential natural antioxidants with minimum side effects. The purpose of this study was to determine the antioxidant activity, total phenolic, and flavonoid contents of the extract of endophytic fungi which were derived from the Bogor-originated turmeric leaves via in vitro isolation. DPPH free radical scavenging method was used to determine in vitro antioxidant activity. The total phenolic and flavonoid contents assays were based on the Follin-Ciocalteu and aluminium chloride reagents, respectively. The extract of endophytic fungi of Bo.Ci.Cl.D1 and Bo.Ci.Cl.D2 showed antioxidant activity with IC50 value at 24.04 and 96.08 mg/L, respectively. Total phenolic content of Bo.Ci.Cl.D1 and Bo.Ci.Cl.D2 extracts were 113.47 and 81.83 mg gallic acid equivalent/g extract respectively. Total flavonoid content of Bo.Cl.D1 and Bo.Ci.Cl.D2 extracts were 41.79 and 38.50 mg quercetin equivalent/g extract, respectively. Based on these assays, it could be concluded that the extract of Bo.Ci.Cl.D1 has better antioxidant activities than Bo.Ci.Cl.D2.

show abstract

Decreasing Free Radicals Level on High Risk Person After Vitamin C and E Supplement Treatment

Cited by 7 publications

References 17 publications

Effects of Paper Mulberry (Broussonetia papyrifera) Leaf Extract on Growth Performance and Fecal Microflora of Weaned Piglets

Effects of Paper Mulberry (Broussonetia papyrifera) Leaf Extract on Growth Performance and Fecal Microflora of Weaned Piglets

Biomarker of Oxidative Stress in Premature Hair Graying at Young Age

ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC, AND FLAVONOID CONTENTS OF THE EXTRACT OF ENDOPHYTIC FUNGI DERIVED FROM TURMERIC (Curcuma longa) LEAVES

Contact Info

Product

Resources

About