Decreasing postoperative cognitive deficits after heart surgery: Protocol for a randomized controlled trial on cognitive training

Abstract

Background The occurrence of postoperative cognitive deficits, especially after heart surgery, has been demonstrated in several studies. These deficits can clearly be noticed by the patients as well as by their close relatives in daily life. Furthermore, postoperative cognitive deficits can decrease quality of life in social functioning and earning capacity. The aim of this study is to investigate whether early postoperative cognitive training can reduce subjective and objective postoperative cognitive deficits Methods The proposed study is a multicenter, 2-arm randomized controlled trial involving 144 elderly patients undergoing elective heart valve surgery with extracorporeal circulation. Patients will be assigned to either a training group or a control group. The intervention involves a paper-and-pencil-based cognitive training, which is conducted for 36 minutes over a period of 18 days. The training starts about 1 week after surgery and is carried out during the hospitalized rehabilitation phase. The control group will not receive a cognitive training or a placebo intervention. A detailed assessment of psychological functions and health-related quality of life prior to surgery at discharge from rehabilitation and 3 and 12 months after discharge will be performed. The Primary outcome of this trial is the training effect on objective cognitive functions at discharge from rehabilitation. Secondary outcomes are the training effect on objective and subjective cognitive functions (3 and 12 months after discharge), depression, health-related quality of life, and the impact of perioperative cerebral ischemia on the training effect. Perioperative cerebral ischemia will be measured with postoperative magnetic resonance imaging including diffusion-weighted sequences. Discussion Should it be shown that our cognitive training can improve postoperative cognitive deficits as well as quality of life, one possibility could be to integrate this intervention into early rehabilitation. Furthermore, we hope that the investigation of perioperative ischemia by diffusion-weighted magnetic resonance imaging will improve our understanding of neurobiological factors influencing the course of postoperative cognitive plasticity.

Delirium and depression in cardiac surgery: A comprehensive review of risk factors, pathophysiology, and management

“…These measures help to stimulate and mobilize patients' physical and psychological capabilities. 101 HASSANABAD ET AL.…”

“…Approaches, such as paper‐and‐pencil‐based cognitive training programs, have been utilized to provide patients with postoperative support. These measures help to stimulate and mobilize patients' physical and psychological capabilities 101 …”

“…These measures help to stimulate and mobilize patients' physical and psychological capabilities. 101 Postoperative patient education aims to convey enough and appropriate self-care information to reduce symptoms and complications after discharge and improve QoL. 102 Education also helps patients learn more about their surgery and the recovery process so that they can effectively manage postoperative complications and prevent mortality and rehospitalization.…”