Decreasing the Expression Level of Macrophage Cell, Pro-Inflammatory Cytokines and NF-κB by Using VipAlbumin® in vitro

Dwij, Dinia Rizqi; Dj, Mitchell; Rifa’i, Muhaimin

doi:10.3923/ajcb.2015.43.56

Cited by 4 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pro-inflammatory cytokine TNF-α, IFN-γ and IL-6 are included among the group pro-inflammatory cytokines that can cause chronic inflammation (Dwijayanti et al, 2015). As shown in Figure 1, this study showed that the relative amount of TNF-α and IFN-γ secreted by CD4 + T cells, and IL-6 and IFN-γ secreted by macrophages (CD11b + ), was significantly increased (p < .05) in inflammatory conditions when compared to the control.…”

Section: Resultsmentioning

confidence: 99%

“…These chemical factors are released by inflammation-mediating cells that act in the immune system to protect tissue from infection. Prolonged inflammation (called chronic inflammation) can lead to various diseases such as autoimmune diseases, diabetes mellitus, cardiovascular diseases, pulmonary diseases and cancer (Dwijayanti, Djati, & Rifa'i, 2015;Yen et al, 2006). Therefore, chronic inflammation must be treated immediately to prevent these dangerous diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-Inflammatory evaluation of black rice extract inhibits TNF-α, IFN-γ and IL-6 cytokines produced by immunocompetent cells

Hartati

Widjanarko

Widyaningsih

et al. 2017

Food and Agricultural Immunology

View full text Add to dashboard Cite

Black rice has been known for its many beneficial effects to our body because it contains several chemical compounds that act as antiinflammatory agents. This study aims to compare the antiinflammatory activity of ethanol extract and aqueous extract of black rice. Anti-inflammatory activity test was performed in vitro on splenocytes of diabetes mellitus mice model as the control of inflammation. Cells were cultured in Roswell Park Memorial Institute medium with 10% fetal bovine serum, anti-CD3 and lipopolysaccharide and black rice extract 50, 100 and 200 µg/mL. In day 3, cells were harvested, stained and analyzed by flow cytometry. The result shows that the ethanol extract and aqueous extract of black rice have anti-inflammatory activity. 50 µg/mL black rice aqueous extract has the most extensive antiinflammatory activity indicated by increased T reg cells, decreased nuclear factor kappa B activity on CD4 + , CD8 + T cells, decreased production of TNF-α by CD4 + T cells, decreased production of IL-6 and IFN-γ by macrophages.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory evaluation of black rice extract inhibits TNF-α, IFN-γ and IL-6 cytokines produced by immunocompetent cells

Hartati

Widjanarko

Widyaningsih

et al. 2017

Food and Agricultural Immunology

View full text Add to dashboard Cite

show abstract

“…It can also increase IGF-1 levels and decrease IL-6 levels, which are important factors in sarcopenia. Several studies have shown decreases in IL-6 and TNF-α levels after using Ophiocephalus striatus extract [ 12 , 18 , 22 ]. A study on cancer patients with cachexia found a significant reduction in IL-6 levels after two weeks of using Ophiocephalus striatus extract [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Ophiocephalus striatus Extract Supplementation Decreases Serum IL-6 Levels in Older People with Sarcopenia—A Single-Center Experience

Riviati,

Legiran,

Saleh

et al. 2024

Geriatrics

View full text Add to dashboard Cite

Sarcopenia, a condition characterized by muscle loss and decreased function in older adults, is a growing public health concern. This study aimed to investigate the effects of Ophiocephalus striatus extract on insulin-like growth factor-1 serum, interleukin-6 serum levels, and sarcopenia-related parameters in older adults with sarcopenia. This double-blind randomized controlled trial included 80 older adults with sarcopenia. Participants were randomly assigned to receive Ophiocephalus striatus extract or a placebo for two weeks. The IGF-1 serum and IL-6 serum levels were assessed as primary outcomes. The Ophiocephalus striatus extract intervention resulted in a significant reduction in serum IL-6 levels. Although the IGF-1 levels did not show significant changes, there was an increase for the intervention group. This study demonstrated that a 2-week intervention with Ophiocephalus striatus extract positively impacted the serum IL-6 levels in older adults with sarcopenia. While the IGF-1 levels did not change significantly in this short intervention period, the observed improvements in IGF-1, calf circumference, muscle mass, and muscle strength are promising. The findings suggest that Ophiocephalus striatus extract may offer a valuable intervention for managing sarcopenia, particularly in regions with abundant Ophiocephalus striatus production, such as South Sumatera. This study was registered with trial number NCT05869383.

show abstract

Tapak liman (Elephantopus scaber L) extract–induced CD4+ and CD8+ differentiation from hematopoietic stem cells and progenitor cell proliferation in mice (Mus musculus L)

Djati

Habibu²,

Jatiatmaja³

et al. 2017

AIP Conference Proceedings

View full text Add to dashboard Cite

Decreasing the Expression Level of Macrophage Cell, Pro-Inflammatory Cytokines and NF-κB by Using VipAlbumin® in vitro

Abstract: Inflammation is a physiological response to an injury and disruption by the external factor. VipAlbumin ® is a one of the supplement that has anti-inflammatory activity. This study wants to know the effect of VipAlbumin

Cited by 4 publications

References 35 publications

Anti-Inflammatory evaluation of black rice extract inhibits TNF-α, IFN-γ and IL-6 cytokines produced by immunocompetent cells

Anti-Inflammatory evaluation of black rice extract inhibits TNF-α, IFN-γ and IL-6 cytokines produced by immunocompetent cells

Ophiocephalus striatus Extract Supplementation Decreases Serum IL-6 Levels in Older People with Sarcopenia—A Single-Center Experience

Tapak liman (Elephantopus scaber L) extract–induced CD4+ and CD8+ differentiation from hematopoietic stem cells and progenitor cell proliferation in mice (Mus musculus L)

Contact Info

Product

Resources

About