Decreasing urinary organophosphate pesticide metabolites among pregnant women and their offspring in Jerusalem: Impact of regulatory restrictions on agricultural organophosphate pesticides use?

Ein-Mor, Eliana; Ergaz‐Shaltiel, Zivanit; Berman, Tamar; Göen, Thomas; Natsheh, Juma; Ben-Chetrit, Avraham; Haimov‐Kochman, Ronit; Calderon‐Margalit, Ronit

doi:10.1016/j.ijheh.2018.03.013

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…To the best of our knowledge, this is the first study to investigate urinary DAP concentrations of Japanese pregnant women on this scale. Urinary DAP concentrations were comparable with those in another Japanese study [ 21 ] and in previous studies from other countries [ 3 , 6 , 48 , 49 , 50 , 51 , 52 ]. In this study, strict QC measures were employed such as reproducibility, repeatability (intermediate precision), blank test, linearity of the calibration curves, duplicated measurements, recovery of IS samples, target ion/qualifier ion ratio and external QC.…”

Section: Discussionsupporting

confidence: 88%

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Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose10.

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Section: Discussionsupporting

confidence: 88%

“…This study found that urinary DAP concentrations of pregnant women were lower than in previous studies [ 3 , 6 , 48 , 49 , 50 , 51 , 52 ]. The month of urine sampling, consumption of apple and maternal BMI were the main predictors of urinary OPP metabolites, similar to previous studies [ 10 , 11 ].…”

Section: Discussioncontrasting

confidence: 76%

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Nishihama

Nakayama

Isobe

et al. 2021

IJERPH

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“…2). With a detection frequency of 53% for DEP and 47% for DETP with respective median contents values of 0.87 mg/L and <0.5 mg/L, this study has presented a slightly lower DAPs exposure when compared to studies on 240 Belgian children (with 1.8 mg/L of DEP) [15], on 136 Thai farmers (with DEP median value <LOQ and 1.2 mg/L of DETP) [37], and on 273 pregnant women in Jerusalem (with 2.72 mg/L of DEP and 0.55 mg/L of DETP) [38] (Table 4).…”

Section: Pyrethroids and Dialkylphosphate Pesticidescontrasting

confidence: 58%

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): A small pilot study

Bayebila

Dufour

Pirard

et al. 2021

Preprint

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BackgroundEnvironmental pollutants are known to be ubiquitous and may present toxic effects (endocrine-disruption properties, carcinogenicity…). Therefore, they represent a real threat to human health. The aim of the present study was to assess the content of environmental pollutants (inorganic, persistent, and non-persistent pollutants) in biological samples (urine, serum, and whole blood), collected from volunteers in Kinshasa, capital of Democratic Republic of Congo, in order to estimate the exposure level in the population of Kinshasa to environmental pollutants.MethodsFrom randomly selected 15 volunteers living in Kinshasa, aged from 25 to 66 years, including 10 men and 5 women, urine, whole blood, and serum samples were used in this study to estimate the contents in these environmental pollutants, using Inductively Coupled Plasma Mass Spectrometry, Gas Chromatography coupled to Mass Spectrometry, and Liquid Chromatography coupled to Mass Spectrometry.ResultsWhen compared to data nationally and internationally available, the preliminary outcomes of this study indicated a high level of exposure to environmental pollutants in the population of Kinshasa, especially for arsenic, cadmium, lead, benzophenone-3, methyl-paraben, propyl-paraben, triclosan, mono-ethyl phthalate, mono-n-butyl phthalate, 3-phenoxybenzoic acid, cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid, and for 3,5,6-trichloro-2-pyridinol. The levels of 4,4’dichloro-diphenyl-dichloro-ethylene and glyphosate were also significant although some heavily exposed populations showed higher level of contamination. In contrast, the investigated population of Kinshasa was found to weakly exposed to other pollutants like bisphenol A, dialkyl phosphates, polychlorinated biphenyls, brominated flame retardants, phenolic organo-halogens, and perfluoroalkyl substances.ConclusionAlthough the biologic fluids were collected from a limited number of volunteers (n = 15), the results of the present report clearly indicate that the population of Kinshasa is not spared by the investigated environmental pollutants.Trial registration: this study was retrospectively registered by the national health ethics committee in the Congo under the series number of 159/CNES/BN/PMMF/2020.

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“…2 ). With a detection frequency of 53% for DEP and 47% for DETP with respective median contents values of 0.87 μg/L and < 0.5 μg/L, this study has presented a slightly lower DAPs exposure when compared to studies on 240 Belgian children (with 1.8 μg/L of DEP) [ 15 ], on 136 Thai farmers (with DEP median value <LOQ and 1.2 μg/L of DETP) [ 37 ], and on 273 pregnant women in Jerusalem (with 2.72 μg/L of DEP and 0.55 μg/L of DETP) [ 38 ] (Table 4 ).…”

Section: Discussionmentioning

confidence: 85%

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): a small pilot study

et al. 2021

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Background Environmental pollutants are known to be ubiquitous and may present toxic effects (endocrine-disruption properties, carcinogenicity …) and represent a real threat to human health. The aim of the present pilot study was to assess the content of environmental pollutants (inorganic, persistent, and non-persistent pollutants) in biological samples (urine, serum, and whole blood), collected from volunteers in Kinshasa, capital of Democratic Republic of Congo, in order to identify pollutants of interest and to design a protocol for a larger scale study. Methods From randomly selected 15 volunteers living in Kinshasa, aged from 25 to 66 years, (mean age = 43.4 years), including 10 men and 5 women, urine, whole blood, and serum samples were used in this study to estimate the contents in these environmental pollutants, using inductively coupled plasma mass spectrometry, gas chromatography coupled to mass spectrometry, and liquid chromatography coupled to mass spectrometry. Results When compared to data nationally and internationally available, the preliminary outcomes of this study indicated a very high level of exposure to environmental pollutants in the population of Kinshasa, especially for heavy metals, parabens and triclosan. To a lesser extent, contamination measured for glyphosate, phthalates, organochlorine pesticides, pyrethroids and dialkylphosphate pesticides was also significant. In contrast, the investigated population of Kinshasa was found to be weakly exposed to other persistent organic pollutants like polychlorinated biphenyls, brominated flame retardants, phenolic organohalogens, and perfluoroalkyl substances. Conclusion Although the biologic fluids were collected from a limited number of volunteers (n = 15), the results of the present report clearly indicate that the population of Kinshasa is not spared by the investigated environmental pollutants. Moreover, this study gives us important information to design a larger scale study protocol.

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Decreasing urinary organophosphate pesticide metabolites among pregnant women and their offspring in Jerusalem: Impact of regulatory restrictions on agricultural organophosphate pesticides use?

Cited by 12 publications

References 24 publications

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): A small pilot study

Bio-surveillance of environmental pollutants in the population of Kinshasa, Democratic Republic of Congo (DRC): a small pilot study

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