Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Schillaci, Orazio; Danieli, Roberta

doi:10.1007/s00259-010-1526-x

Cited by 22 publications

(18 citation statements)

References 17 publications

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“…High liver radioactivity accumulation may interfere with visualization of the inferior wall of the heart using the standard SPECT cameras. For ultra-fast cardiac SPECT cameras, it is possible to position the patient upright during image acquisition, which would be helpful in minimizing the interference from the liver radioactivity because liver tends to drop downward in this position, allowing better separation of the cardiac and hepatic radioactivity [9,51,52]. As a result of their fast heart washout and prolonged liver radioactivity accumulation, we believe that 99m Tc-Teboroxime and 99m Tc-Teboroxime(N 3 ) are better suited for early image acquisition with ultra-fast cardiac SPECT cameras.…”

Section: Discussionmentioning

confidence: 99%

Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime)

Zheng

Tomaselli

et al. 2014

Nuclear Medicine and Biology

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Introduction 99mTc-Teboroxime ([99mTcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of 99mTc(III) complexes. This study sought to explore the impact of co-ligands on solution stability, heart uptake and myocardial retention of [99mTc(L)(CDO)(CDOH)2BMe] (99mTc-Teboroxime: L = Cl; 99mTc-Teboroxime(F): L = F; 99mTc-Teboroxime(SCN): L = SCN; and 99mTc-Teboroxime(N3): L = N3). Methods Radiotracers 99mTc-Teboroxime(L) (L = F, SCN and N3) were prepared by reacting 99mTc-Teboroxime with NaF, NaSCN and NaN3, respectively. Biodistribution and imaging studies were carried out in Sprague-Dawley rats. Image quantification was performed to compare their heart retention and liver clearance kinetics. Results Complexes 99mTc-Teboroxime(L) (L = F, SCN and N3) were prepared in high yield with high radiochemical purity. All new radiotracers were stable for >6 h in the kit matrix. In its HPLC chromatogram, 99mTc-Teboroxime showed one peak at ~15.5 min, which was shorter than that of 99mTc-Teboroxime(F) (~16.4 min). There were two peaks for 99mTc-Teboroxime(SCN) at 16.5 and 18.3 min. 99mTc-Teboroxime(N3) appeared as a single peak at 18.4 min. Their heart retention and liver clearance curves were best fitted to the bi-exponential decay function. The half-times of fast/slow components were 1.6 ± 0.4/60.7±8.9 min for 99mTc-Teboroxime, 0.8±0.2/101.7±20.7 min for 99mTc-Teboroxime(F), 1.2±0.3/84.8±16.6 min for 99mTc-Teboroxime(SCN), and 2.9±0.9/51.6±5.0 min for 99mTc-Teboroxime(N3). The 2-min heart uptake followed the order of 99mTc-Teboroxime (3.00±0.37%ID/g) > 99mTc-Teboroxime(N3) (2.66±0.01 %ID/g) ≈ 99mTc-Sestamibi (2.55±0.46 %ID/g) > 99mTcN-MPO (2.38±0.15 %ID/g). 99mTc-Teboroxime remains the best in first-pass extraction. The best image acquisition window is 0 – 5 min for 99mTc-Teboroximine and 0 – 15 min for 99mTc-Teboroximine(N3). Conclusion Co-ligands had significant impact on the heart uptake and myocardial retention of complexes [99mTc(L)(CDO)(CDOH)2BMe] (L = Cl, F, SCN and N3). Future studies should be directed towards minimizing the liver uptake and radioactivity accumulation in the blood vessels while maintaining their high heart uptake.

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Section: Discussionmentioning

confidence: 99%

Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime)

Zheng

Tomaselli

et al. 2014

Nuclear Medicine and Biology

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“…These improved systems enhance the sensitivity of count detection and thereby enable recording times or tracer doses to be reduced, a property that has highly favorable consequences on patient comfort and radiation exposure (1)(2)(3)(4). This enhancement is based mainly on acquisitions that are heart-centric but obtained with very different technologies: first, for the IQÁSPECT system (Siemens Medical Solutions (5-8)), an Anger camera equipped with collimators convergent on the image center (astigmatic collimators); second, for the DSPECT system (Spectrum Dynamics (9-13)), mobile columns of CZT detectors with wide parallel-hole collimators; and third, for the Discovery NM 530c system (GE Healthcare (14)(15)(16)(17)(18)(19)(20)(21)), fixed CZT detectors with multipinhole collimators.…”

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confidence: 99%

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

et al. 2012

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Differences in the performance of cadmium-zinc-telluride (CZT) cameras or collimation systems that have recently been commercialized for myocardial SPECT remain unclear. In the present study, the performance of 3 of these systems was compared by a comprehensive analysis of phantom and human SPECT images. Methods: We evaluated the Discovery NM 530c and DSPECT CZT cameras, as well as the Symbia Anger camera equipped with an astigmatic (IQÁSPECT) or parallel-hole (conventional SPECT) collimator. Physical performance was compared on reconstructed SPECT images from a phantom and from comparable groups of healthy subjects. Results: Classifications were as follows, in order of performance. For count sensitivity on cardiac phantom images (countsÁs 21 ÁMBq 21 ), DSPECT had a sensitivity of 850; Discovery NM 530c, 460; IQÁSPECT, 390; and conventional SPECT, 130. This classification was similar to that of myocardial counts normalized to injected activities from human images (respective mean values, in countsÁs 21 ÁMBq 21 : 11.4 6 2.6, 5.6 6 1.4, 2.7 6 0.7, and 0.6 6 0.1). For central spatial resolution: Discovery NM 530c was 6.7 mm; DSPECT, 8.6 mm; IQÁSPECT, 15.0 mm; and conventional SPECT, 15.3 mm, also in accordance with the analysis of the sharpness of myocardial contours on human images (in cm 21 : 1.02 6 0.17, 0.92 6 0.11, 0.64 6 0.12, and 0.65 6 0.06, respectively). For contrast-to-noise ratio on the phantom: Discovery NM 530c had a ratio of 4.6; DSPECT, 4.1; IQÁSPECT, 3.9; and conventional SPECT, 3.5, similar to ratios documented on human images (5.2 6 1.0, 4.5 6 0.5, 3.9 6 0.6, and 3.4 6 0.3, respectively). Conclusion: The performance of CZT cameras is dramatically higher than that of Anger cameras, even for human SPECT images. However, CZT cameras differ in that spatial resolution and contrast-to-noise ratio are better with the Discovery NM 530c, whereas count sensitivity is markedly higher with the DSPECT.Key Words: CZT-cameras; high-speed SPECT; myocardial perfusion imaging; count sensitivity St ress myocardial SPECT has been markedly enhanced by the recent commercialization of cameras with semiconductor (cadmium-zinc-telluride [CZT]) detectors or new collimation systems. These improved systems enhance the sensitivity of count detection and thereby enable recording times or tracer doses to be reduced, a property that has highly favorable consequences on patient comfort and radiation exposure (1-4). This enhancement is based mainly on acquisitions that are heart-centric but obtained with very different technologies: first, for the IQÁSPECT system (Siemens Medical Solutions (5-8)), an Anger camera equipped with collimators convergent on the image center (astigmatic collimators); second, for the DSPECT system (Spectrum Dynamics (9-13)), mobile columns of CZT detectors with wide parallel-hole collimators; and third, for the Discovery NM 530c system (GE Healthcare (14-21)), fixed CZT detectors with multipinhole collimators.The respective performance of these new cameras and collimation systems has been analyzed, but ...

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“…Cependant, c'est très certainement l'arrivée de caméras à semi-conducteurs CZT qui constitue la plus importante évolution technologique [21][22][23][24][25][26]. En comparaison aux caméras conventionnelles à scintillation, la sensibilité de détection de ces caméras CZT (qui représente le pourcentage de l'activité myocardique pouvant être détectée) est augmentée d'un facteur 6 à 10.…”

Section: Confort Et Sécurité Des Patientsunclassified

“…En comparaison aux caméras conventionnelles à scintillation, la sensibilité de détection de ces caméras CZT (qui représente le pourcentage de l'activité myocardique pouvant être détectée) est augmentée d'un facteur 6 à 10. Ceci permet de diminuer de manière encore plus drastique les activités injectées ainsi que les temps d'enregistrement [21][22][23][24]. Dans ces conditions, les doses absorbées par les patients peuvent être très faibles : de l'ordre de 3 mSv pour une séquence d'examen eff ortrepos réalisée avec un traceur marqué par le technétium-99m (Sestamibi ou Té-trofosmine), voire 1 mSv seulement si l'acquisition d'eff ort est normale et qu'il n'y a pas besoin d'eff ectuer une deuxième acquisition au repos [24].…”

Section: Confort Et Sécurité Des Patientsunclassified

Limites de la tomoscintigraphie myocardique (TSM)

Manrique

2013

Imagerie en Coupes Du Cœur Et Des Vaisseaux

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Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Cited by 22 publications

References 17 publications

Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime)

Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L=Cl, F, SCN and N3; CDOH2=cyclohexanedione dioxime)

Compared Performance of High-Sensitivity Cameras Dedicated to Myocardial Perfusion SPECT: A Comprehensive Analysis of Phantom and Human Images

Limites de la tomoscintigraphie myocardique (TSM)

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