Deep and precise lighting-up/combat diseases through sonodynamic agents integrating molecular imaging and therapy modalities

Yang, Huocheng; Tu, Le; Li, Jie; Bai, Suya; Hu, Zongxing; Yin, Peng; Lin, Huiyu; Qi, Yu; Zhu, Hongda; Sun, Yao

doi:10.1016/j.ccr.2021.214333

Cited by 39 publications

(16 citation statements)

References 84 publications

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“…Besides, the properties of long wavelength and ideal fluorescence brightness are often not available at the same time. 40,41 In addition, fluorescent imaging results are always better in small animals than in humans. Therefore, we will move on to balancing the properties of wavelength and fluorescence brightness, and strive to build stable and bright fluorescent dyes and fluorescent probes with low background interference and large penetration depth in the future, to provide ideal opti-…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

New High-Performance Fluorescent Dye Scaffolds: Applications for Bioimaging and Biosensing

Cheng

Lei

2023

Synlett

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Fluorescence imaging in the short-wave infrared region (SWIR, 850-2500 nm) window has become an indispensable tool in biomedical research with weaker absorption, less light scattering, and less background fluorescence in this window. As we know, the design and synthesis of fluorescent dyes and fluorescent probes are the cores of fluorescence imaging and biosensing. Thus, their photophysical mechanisms exploring and bioanalytical applications are multidisciplinary and cutting-edge research topics. In this regard, we have been working on high-performance fluorescent dyes and fluorescent probes for years. In short, we have developed a series of bright, stable, aggregation-resistant, SWIR fluorescent dyes ECXs, based on a carbon-bridged spiro ring strategy. Besides, we also developed a series of high-performance SWIR fluorescent dyes CXs and Chrodols, which combine the structural advantages of cyanine and xanthenoid dyes. Based on these new SWIR scaffolds, we further constructed some activatable SWIR fluorescent probes with OFF-ON or ratiometric properties for biosensing in vivo. Therefore, the mainline of our work is to deeply understand the photophysical mechanisms of fluorescent dyes, to create high-performance luminescent dyes, and further develop fluorescent probes for bioimaging and biosensing.

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Section: Conclusion and Future Prospectsmentioning

confidence: 99%

New High-Performance Fluorescent Dye Scaffolds: Applications for Bioimaging and Biosensing

Cheng

Lei

2023

Synlett

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“…12−16 Sonodynamic therapy (SDT), which is developed on the basis of photodynamic therapy (PDT), is a compelling sonosensitizer-mediated technology under ultrasound (US) irradiation. 17,18 Actually, US irradiation has been early utilized in the biomedical applications expanding from clinical imaging to therapeutic applications, and accordingly, it often serves as a typical tool for cancer diagnoses and treatments. For example, sonography is a known diagnostic technique because US irradiation intrinsically features the ability of high penetration at the targeting sites with a minimal damage to the surrounding normal tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Sonodynamic therapy (SDT), which is developed on the basis of photodynamic therapy (PDT), is a compelling sonosensitizer-mediated technology under ultrasound (US) irradiation. , Actually, US irradiation has been early utilized in the biomedical applications expanding from clinical imaging to therapeutic applications, and accordingly, it often serves as a typical tool for cancer diagnoses and treatments. For example, sonography is a known diagnostic technique because US irradiation intrinsically features the ability of high penetration at the targeting sites with a minimal damage to the surrounding normal tissues. , In therapeutics, US irradiation has a wide application range since different biological effects are induced by its different intensities and frequencies: Low-intensity US irradiation can produce nonthermal biological effects for the therapeutics, where ultrasonic cavitation acts as a stimulus of microbubbles to accelerate the delivery of therapeutic drugs to those deep tumors or solid tumors. , Also, the biological effects of high-intensity US irradiation can be used in therapeutics: High-intensity focused US (HIFU) irradiation has completed tumor ablation by inducing hyperthermia, and high-intensity pulsed US irradiation has carried out thermal tumor fractionation. − In a broad sense, SDT can be consider as a biological effect from low-intensity US irradiation, or specifically, it integrates the localized cytotoxicity of sonosensitizers and low-intensity US irradiation.…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Yang

Dong

et al. 2023

ACS Nano

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Sonodynamic therapy (SDT) has emerged as a promising therapeutic modality for anticancer treatments and is becoming a cutting-edge interdisciplinary research field. This review starts with the latest developments of SDT and provides a brief comprehensive discussion on ultrasonic cavitation, sonodynamic effect, and sonosensitizers in order to popularize the basic principles and probable mechanisms of SDT. Then the recent progress of MOF-based sonosensitizers is overviewed, and the preparation methods and properties (e.g., morphology, structure, and size) of products are presented in a fundamental perspective. More importantly, many deep observations and understanding toward MOF-assisted SDT strategies were described in anticancer applications, aiming to highlight the advantages and improvements of MOF-augmented SDT and synergistic therapies. Last but not least, the review also pointed out the probable challenges and technological potential of MOF-assisted SDT for the future advance. In all, the discussions and summaries of MOF-based sonosensitizers and SDT strategies will promote the fast development of anticancer nanodrugs and biotechnologies.

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“…With the development of technology, many novelty methods have been designed to augment the antitumor therapy efficiency. For example, the chemodynamic therapy (CDT), 2–5 sonodynamic therapy (SDT), 6–10 photothermal therapy (PTT), 11–13 photodynamic therapy (PDT), 14–17 radiotherapy (RT), 18 immunotherapy, 19–21 and starvation therapy (ST) 22 . However, limited to the tumor microenvironment and the complexity, and heterogeneity of the cancers, each of the modality aboved has its drawbacks and advantages.…”

Section: Introductionmentioning

confidence: 99%

Precision gas therapy by ultrasound‐triggered for anticancer therapeutics

Guo

Feng

et al. 2023

MedComm – Oncology

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In recent years, ultrasound, as an external stimuli that can activate different types of naonocatalysts for therapy, has attracted extensive attention. One characteristic that makes ultrasound a particularly attractive trigger stimulus for nanomedicine is that it can be applied to the deep regions of the body noninvasively in a focused way. Different biological effects can be achieved by integrating ultrasound with nanocatalysts, and nanodroplets. Gas therapy, as a green antitumor treatment, has attracted substantial attention. The development of nanotechnology and nanomedicine has made gas therapy more precious by controlled release under internal, and outside factors and targeted delivery. In this article, an overview of ultrasound-based gas therapy on antitumor therapy has been provided. First, we explored the mechanism of ultrasound-triggered gas release. Second, we list the common gas release pathways and their mechanism in response to ultrasound activity. Third, exemplary instances of gas-generating facilities under ultrasound controllable are explored, with an emphasis on their originality and guiding principles. The impact of the gas-generating platform as a tumor therapy has also been considered. Finally, the difficulties and future prospects for this effective therapeutic approach are examined.

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Deep and precise lighting-up/combat diseases through sonodynamic agents integrating molecular imaging and therapy modalities

Cited by 39 publications

References 84 publications

New High-Performance Fluorescent Dye Scaffolds: Applications for Bioimaging and Biosensing

New High-Performance Fluorescent Dye Scaffolds: Applications for Bioimaging and Biosensing

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Precision gas therapy by ultrasound‐triggered for anticancer therapeutics

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