Deep brain stimulation for treatment-resistant depression: Predicting response and optimizing treatment

Are modern neuromodulation therapies too precise?

“…Investigational trials in deep brain stimulation (DBS) for TRD have also shown efficacy using very specific neuroanatomical targets (e.g., subgenual cingulate cortex) in some of the most treatment resistant patients (e.g., patients who failed ECT). Conroy and Holtzheimer et al [26] review the available data on the use of the most precisely targeted neuromodulation therapy. Research in DBS received a setback when the Broaden trial was halted due to a lack of efficacy.…”