Deep Cerebellar Nuclei Functional Connectivity with Cerebral Cortex in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic–Clonic Seizures: a Resting-State fMRI Study

Nie, Liluo; Jiang, Yanchun; Lv, Zongxia; Pang, Xiaomin; Liang, Xiulin; Chang, Weiwei; Li, Jian; Zheng, Jinou

doi:10.1007/s12311-021-01266-3

Cited by 7 publications

(10 citation statements)

References 41 publications

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“…In addition, the volume alteration of the vermis is correlated with the temporal lobe volume ( 63 ). However, functional studies of the cerebellum failed to confirm a relationship between disease burden and functional alterations ( 2 , 3 ). Notably, cerebellar functional abnormalities also did not correlate with the clinical features in this study.…”

Section: Discussionmentioning

confidence: 99%

“…During the attentional network test, activation in the cerebellum was reduced in patients with MTLE compared to healthy controls (HC) ( 27 ). Impaired functional connectivity between the right dentate nuclei and the left cerebral hemisphere was related to cognitive impairment in MTLE ( 2 , 3 ). Graph theory analyses provided additional knowledge regarding the role of cerebellar regions in TLE.…”

Section: Introductionmentioning

confidence: 99%

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Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy

et al. 2023

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BackgroundCerebellar functional alterations are common in patients with mesial temporal lobe epilepsy (MTLE), which contribute to cognitive decline. This study aimed to deepen our knowledge of cerebellar functional alterations in patients with MTLE.MethodsIn this study, participants were recruited from an ongoing prospective cohort of 13 patients with left TLE (LTLE), 17 patients with right TLE (RTLE), and 30 healthy controls (HCs). Functional magnetic resonance imaging data were collected during a Chinese verbal fluency task. Group independent component (IC) analysis (group ICA) was applied to segment the cerebellum into six functionally separated networks. Functional connectivity was compared among cerebellar networks, cerebellar activation maps, and the centrality parameters of cerebellar regions. For cerebellar functional profiles with significant differences, we calculated their correlation with clinical features and neuropsychological scores.ResultCompared to HCs and patients with LTLE, patients with RTLE had higher cerebellar functional connectivity between the default mode network (DMN) and the oculomotor network and lower cerebellar functional connectivity from the frontoparietal network (FPN) to the dorsal attention network (DAN) (p < 0.05, false discovery rate- (FDR-) corrected). Cerebellar degree centrality (DC) of the right lobule III was significantly higher in patients with LTLE compared to HC and patients with RTLE (p < 0.05, FDR-corrected). Higher cerebellar functional connectivity between the DMN and the oculomotor network, as well as lower cerebellar degree centrality of the right lobule III, was correlated with worse information test performance.ConclusionCerebellar functional profiles were altered in MTLE and correlated with long-term memory in patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy

et al. 2023

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“…A lesion in the PCL can result in cerebellar cognitive-affective syndrome, characterized by issues with executive function, visual-spatial processing, linguistic abilities, and emotional regulation. In TLE with or without FBTCS as well as right TLE, we previously described aberrant FC between deep cerebellar nuclei and the cerebral cortex ( 38 , 39 ). In the current study, we found decreased rsFC between Ch1-3 and the left posterior cerebellar lobe in FBTCS patients, which is consistent with earlier findings.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure

Fan

Pang

et al. 2022

Front. Psychiatry

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PurposePrevious research has shown that subcortical brain regions are related to vigilance in temporal lobe epilepsy (TLE). However, it is unknown whether alterations in the function and structure of basal forebrain (BF) subregions are associated with vigilance impairment in distinct kinds of TLE. We aimed to investigate changes in the structure and function BF subregions in TLE patients with and without focal to bilateral tonic-clonic seizures (FBTCS) and associated clinical features.MethodsA total of 50 TLE patients (25 without and 25 with FBTCS) and 25 healthy controls (HCs) were enrolled in this study. The structural and functional alterations of BF subregions in TLE were investigated using voxel-based morphometry (VBM) and resting-state functional connectivity (rsFC) analysis. Correlation analyses were utilized to investigate correlations between substantially altered imaging characteristics and clinical data from patients.ResultsFBTCS patients had a lower rsFC between Ch1-3 and the bilateral striatum as well as the left cerebellum posterior lobe than non-FBTCS patients. In comparison to non-FBTCS patients, the rsFC between Ch4 and the bilateral amygdala was also lower in FBTCS patients. Compared to HCs, the TLE patients had reduced rsFC between the BF subregions and the cerebellum, striatum, default mode network, frontal lobe, and occipital lobes. In the FBTCS group, the rsFC between the left Ch1-3 and striatum was positive correlated with the vigilance measures. In the non-FBTCS group, the rsFC between the left Ch4 and striatum was significantly negative correlated with the alertness measure.ConclusionThese results extend current understanding of the pathophysiology of impaired vigilance in TLE and imply that the BF subregions may serve as critical nodes for developing and categorizing TLE biomarkers.

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“…The authors registered the facilitation of limbic seizures at the early stage of amygdalar kindling with the prevention of secondarily generalized seizures caused by ES of superior cerebellar peduncles with the involvement of the red nucleus in such an effect [39]. Conversely, a decrease in functional links between the nucleus dentatus and contralateral hemisphere, including the forebrain complex determined with fMRI, is followed by a transition from focal to generalized seizures in temporal lobe epilepsy [17]. Similarly, severely changed links between different cortical zones and the cerebellum determined with fMRI in patients with idiopathic generalized epilepsy pointed to the signi cant role of cerebellar structures in epileptic activity modulation [40].…”

Section: Discussionmentioning

confidence: 99%

“…The cerebellum contributes to different types of epileptic manifestations [for review, 8]. Thus, data on the cerebellar role in the development of generalized absence and seizure forms (petit and grand mal) are mainly in the scope of experimental observations [11,[16][17][18], while its contribution to the occurrence of myoclonic manifestations is less clear. Meanwhile, the role of LCN as a part of the myoclonic triangle [19,20] in the pathogenesis of myoclonus might be assumed.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ

Godlevsky

Pervak

Poshyvak

et al. 2022

Preprint

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Background In recent years, the cerebellum and its nuclei have become important targets for understanding and suppressing the mechanisms of seizures. The aim of this study was to investigate the effects of electrical stimulation (ES) applied to the lateral cerebellar nucleus (LCN) in rats with early and fully developed pentylenetetrazol (PTZ)-kindled seizures. MethodsThe experimental groups were represented by rats kindled with PTZ (35.0 mg/kg, i.p.) to myoclonus (9-11 PTZ injections) and generalized tonic-clonic seizures (21 PTZ injections). Unilateral ES (100 Hz, 0.25 ms, 4.5-5.0 duration) was delivered daily for five days after the last kindled PTZ administration with PTZ seizure testing after the last ES. Results ES of LCN performed at the early stage of kindling facilitated the appearance of myoclonus and increased seizure severity by 30.2% - up to 2.25+0.46 scored points compared to the control group (P<0.05). In fully developed kindling, ES prevented generalized seizure and reduced seizure severity by 27.5% - to 3.11+0.31 scored points (P<0.02). In both groups,spikes in the frontal and ventral hippocampus corresponding to myoclonuswere noticed. The linear density of PC in the cerebellar hemisphere cortex was reduced to 9.67±1.12in fully kindled rats, while in the control group, it was 20.17±2.10 per mm (P<0.05). Conclusion The data obtained showed that repeated ES of the LCN at the early kindling stage facilitates myoclonus appearance, while in fully PTZ-kindled rats causes suppression of generalized seizure fits, which were substituted with myoclonus.

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Deep Cerebellar Nuclei Functional Connectivity with Cerebral Cortex in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic–Clonic Seizures: a Resting-State fMRI Study

Cited by 7 publications

References 41 publications

Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy

Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy

Correlation Between the Functional Connectivity of Basal Forebrain Subregions and Vigilance Dysfunction in Temporal Lobe Epilepsy With and Without Focal to Bilateral Tonic-Clonic Seizure

Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ

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