Deep eutectic solvents as sustainable extraction media for plants and food samples: A review

Kaoui, Soukaina; Chebli, Bouchra; Zaidouni, safa; Basaid, Khadija; Mir, Youssef

doi:10.1016/j.scp.2022.100937

Cited by 44 publications

(19 citation statements)

References 98 publications

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“…111,112 A recent review defines NADES as "one of the most promising discoveries in the field of green chemistry", even though high commercial costs of these solvents still limit their use. 113 We refer the readers interested in classifying these peculiar substances to the recent comprehensive review of Justyna Płotka-Wasylka et al (2020). 109 It is impossible to generalize the physical properties of ILs and DESs because of the wide variety of substances that can be obtained by combining the precursors mentioned above.…”

Section: Microwave Assisted Solvent Extraction Of Metabolitesmentioning

confidence: 99%

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Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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Section: Microwave Assisted Solvent Extraction Of Metabolitesmentioning

confidence: 99%

“…111,112 A recent review defines NADES as “one of the most promising discoveries in the field of green chemistry”, even though high commercial costs of these solvents still limit their use. 113…”

Section: Design Of Experiments Approach To Set Up Mase Protocolsmentioning

confidence: 99%

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Cavalloro,

Marrubini,

Rossino

et al. 2024

Green Chem.

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“…Deep eutectic solvents (DESs), showing the merits of easy preparation and generating no waste in the process, have been extensively regarded as a new type of sustainable solvent system . They have been widely explored in a series of fields like active substance extraction, material preparation, biomass processing, water treatment, etc. − In recent decades, active pharmaceutical ingredient (API)-based DESs (generally known as THEDES) have been proposed and shown excellent efficiency in enhancing the solubility, permeation ability, and/or bioavailability of API, , where API can be dissolved in DES or as an ingredient of DES. For instance, Duarte et al reported an obvious enhancement in the solubility and permeability of ibuprofen when transferring it into THEDESs; Jeliński et al showed that the solubility of curcumin in DES prepared from glycerol and choline chloride can be 12 000-fold of that in water, and no degradation of curcumin was observed in this DES within 2 h, while about 95% curcumin in an aqueous solution was degraded …”

Section: Introductionmentioning

confidence: 99%

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Li,

Yuan,

Liu

et al. 2024

Langmuir

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As a serious public health issue, malaria threatens the health of millions of people. Artemisinin, a gift from traditional Chinese medicine, has been used in the treatment of malaria and has shown good therapeutic efficiency. However, due to its low solubility, poor bioavailability, and short half-life time, some smart delivery strategies are still required. Herein, a multifunctional DES prepared from ibuprofen and menthol was prepared. This DES was shown to efficiently promote the solubility of artemisinin up to 400-fold. Then, it was further applied as the oil phase to construct an O/W microemulsion with the help of Tween-80 + Span-20 mixed surfactants. The prepared microemulsion displayed high efficiency in improving the permeability of artemisinin, which can be ascribed to the presence of the permeation enhancer menthol in DES and the microstructure of the O/W microemulsion. Moreover, the simultaneous permeation of artemisinin and ibuprofen further indicated the potential benefits of the presented formulation in the treatment of malaria. To sum up, the microemulsion based on multifunctional DES presented herein provided an effective method for transdermal delivery of artemisinin.

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“…NADES possess numerous advantages, including biocompatibility, ease of preparation, cost‐effectiveness, biodegradability, non‐volatility, and tailor‐made properties compared to organic solvents and ionic liquids (da Silva et al, 2021). These attributes position NADES as a green solution for extracting phenolics, terpenoids, biomacromolecules, and flavonoids (Kaoui et al, 2023). The synergy between NADES and innovative extraction techniques holds excellent potential by improving mass transfer, shortening extraction time, and increasing extraction efficiency (Liu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Green extraction of phenolics and terpenoids from passion fruit peels using natural deep eutectic solvents

Vo,

Phan,

Nguyen

et al. 2023

J Food Process Engineering

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This work aimed to optimize the ultrasonic‐assisted extraction (UAE) and microwave‐assisted extraction (MAE) of phenolics and terpenoids from passion fruit peels using natural deep eutectic solvents (NADES). NADES formulated with choline chloride and polyols with organic acids were used to investigate the solubility of phenolics and flavonoids in the solvent. Among these formulations, those derived from lactic acid‐glycerine (LGLY) and citric acid‐glucose (CGLU) exhibited the highest efficiency in extracting phenolics and terpenoids, respectively, when combined with UAE. Then one‐factor experiments were conducted to examine the influence of the UAE conditions (liquid‐to‐solid ratios [LSR], water content in NADES, ultrasonic power, time, and temperature) and MAE conditions (LSR, water content in NADES, ultrasonic power, and time) on the extraction yield of phenolics and terpenoids. The Box‐Behnken design (BBD) model was employed to optimize the extraction conditions with conditional ranges determined based on the results of the one‐factor experiments. The optimal conditions for the CGLU‐based MAE of terpenoids were 387 W of microwave power, 30% water content, 2.4 min, and 20 mL/g of LSR. The optimized conditions for LGLY‐based MAE of phenolics were 299 W, 18.7%, 1.3 min, and 10 mL/g. Total terpenoid content acquired from NADES‐based UAE was higher than NADES‐based MAE, while total phenolic content obtained at the optimal conditions of NADES‐based UAE and MAE was statistically insignificant. The efficiency of the two extraction ways was compared to selecting the favorable extraction method for acquiring phenolics and flavonoids from passion fruit peels. The research proposed that NADES‐based UAE was a green and effective method for attaining phenolics and terpenoids from passion fruit peel.Practical applicationPassion fruit peels are a by‐product of beverage production, which causes environmental pollution and increases treatment costs in the factory. These peels contain various bioactive compounds which benefit human health. The traditional extraction method shows low efficiency and high energy consumption. Thus, the appropriate extraction method and green solvents are needed to improve the extraction efficiency of bioactive compounds and can be directly applied to food products. Ultrasonic‐assisted extraction (UAE) and microwave‐assisted extraction (MAE) combined with natural deep eutectic solvents can enhance the extraction efficiency of bioactive compounds. However, the detailed conditions of UAE and MAE are necessary to compare the performance of the two methods. In addition to showing the significant superiority of UAE with MAE, the research showed the optimized conditions of the UAE process, which can be applied on the industrial scale to extract bioactive compounds and directly add them to food products.

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Deep eutectic solvents as sustainable extraction media for plants and food samples: A review

Cited by 44 publications

References 98 publications

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Combining DoE and MASE: a winning strategy for the isolation of natural bioactive compounds from plant materials

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Green extraction of phenolics and terpenoids from passion fruit peels using natural deep eutectic solvents

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