Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery

Abstract

Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector. ■ SIGNIFICANCE• DES as solubility enhancer for API.• Drug delivery methods incorporating DES.• Recent developments in techniques using DES to improve API solubility. • Increasing stability of API with DES.• Different models and machine learning models analyzing DES for API solubility. • Future challenges with directions.