Deep eutectic solvents—Hydrogels for the topical management of rheumatoid arthritis

Li, Mingjian; Chen, Hao; Cao, Yubiao; Lin, Yameng; Yang, Ye; Gao, Ming; Zhang, Wen; Wang, Chengxiao

doi:10.1016/j.jconrel.2023.01.050

Cited by 14 publications

(9 citation statements)

References 56 publications

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“…This formulated DES-MSN hydrogel system was applied to the skin of rats to test the skin irritation and the in vivo toxicity of this system. They observed a sustained penetration and accumulation of MSNs at subcutaneous inflammation sites [88].…”

Section: Animal Modelsmentioning

confidence: 98%

“…Previous studies are shown according to their routes of administration and are summarized in Table 3. Injection: topical and subcutaneous (in vivo) Arginine (Arg)-citric acid (CA) + Methotrexate Male Wistar rats [88] Oral (in vivo) Betaine, Mandelic acid (Bet-Man NADES) + RA-XII Healthy male Sprague Dawley rats [89] Oral (in vivo) Fumaric acid + Diacerein 2,4-dihydroxybenzoic acid + Diacerein Healthy Sprague Dawley rats [90,91] Oral (in vivo)…”

Section: Animal Modelsmentioning

confidence: 99%

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Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

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Therapeutic Deep Eutectic Systems (THEDESs) are a mixture of components, including an active pharmaceutical ingredient, that have recently emerged because of their interesting properties for drug therapies. In general, they have been recognized to increase the solubility and permeability of some drugs, and consequently, their bioavailability. Moreover, they have also been used for novel formulations of pharmaceuticals. Despite the potential benefits of THEDESs, concerns about their safety and toxicity remain. In this review, we summarize previous studies that have investigated the toxicity of THEDESs. These studies evaluate the toxicity of THEDESs using various methods, including cell cultures, animal models, and human trials. The results of previous findings suggest that THEDESs are generally well-tolerated and have low toxicity. However, further research is needed to fully understand the long-term effects of these systems on human health and to identify any potential adverse effects.

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Section: Animal Modelsmentioning

confidence: 98%

Section: Animal Modelsmentioning

confidence: 99%

Has the Toxicity of Therapeutic Deep Eutectic Systems Been Assessed?

et al. 2023

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“…itraconazole [a] anti-fungal [136] posaconazole [a] anti-fungal choline chloride glycolic acid piroxicam [a] non-steroidal anti-inflammatory drug solubility enhancement of itraconazole, piroxicam, lidocaine, and posaconazole by 6700, 430, 28, and 6400-fold, respectively, as compared to their water solubility lidocaine [a] local anesthetic choline chloride propylene glycol dapsone [a] FDA-approved for acne treatment. It also has therapeutic activities for a range of dermatological diseases solubility enhancement and topical delivery of dapsone with solubility of 500 mg/mL in DES compared with its solubility in water (380 mg/L) [137] betaine ethylene glycol mesalazine [a] treatment of Crohn's disease and ulcerative colitis the mesalazine solubility in DES + water mixtures increased by increasing mass fractions of DES [138] choline (or acetyl choline) glycolate, lactate, propionate, hexenoate, or geranate insulin [a] and monoclonal antibodies subcutaneous delivery of protein therapeutics incorporation of insulin and monoclonal antibodies in DESs showed an improvement in the pharmacokinetics of insulin and the bioavailability of monoclonal antibodies [139] citric acid arginine mesoporous silica nanoparticles containing nanoceria and methotrexate topical management of rheumatoid arthritis using DES-NPs hydrogel DES-NPs hydrogel formulation resulted in sustained penetration and accumulation of NPs at rheumatoid arthritis sites [140] choline chloride malonic acid tadalafil [a] wound healing and antimicrobial activity tadalafil was dissolved in DES for topical application to avoid systemic exposure. Then, Lidocaine was added to the formulation to provide a local anesthetic effect.…”

Section: Des As a Solvent For Active Pharmaceutical Ingredientsmentioning

confidence: 99%

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

et al. 2023

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In the spirit of circular economy and sustainable chemistry, the use of environmentally friendly chemical products in pharmacy has become a hot topic. In recent years, organic solvents have been the subject of a great range of restriction policies due to their harmful effects on the environment and toxicity to human health. In parallel, deep eutectic solvents (DESs) have emerged as suitable greener solvents with beneficial environmental impacts and a rich palette of physico‐chemical advantages related to their low cost and biocompatibility. Additionally, DESs can be accompanied by a remarkable solubilizing effect for several active pharmaceutical ingredients (APIs), thus forming therapeutic DESs (TheDESs). In this work, special attention is paid to DESs, presenting a precise definition, classification, methods of preparation, and characterization. A description of natural DESs (NaDESs), i.e., eutectic solvents present in natural sources, is also reported. Moreover, the present review article is the first one to detail the different approaches for judiciously selecting the constituents of DESs in order to minimize the number of experiments. The role of DESs in the biomedical and pharmaceutical sectors and their impact on the development of successful therapies are also discussed.

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“…1,2 Particularly, this approach has shown great success in cancer treatment. 3,4 For instance, monoclonal antibodies targeting specific proteins on cancer cells can effectively block or modulate cancerpromoting signals, leading to improved patient outcomes. 5,6 Ribonuclease A (RNase A) is a naturally occurring protein that has gained significant attention in the field of protein therapy, [7][8][9] as it can specifically recognize and bind to the abnormal RNA structure and further cleave the dysregulated RNA molecules to induce the apoptosis of cancer cells.…”

Section: Introductionmentioning

confidence: 99%