Deep eutectic solvents in the extraction of active compounds from Eucommia Ulmoides Oliv. leaves

Liu, Zheng; Ma, Wei; Chen, Bowen; Pan, Hongfang; Zhu, Ming-Qiang; Pang, XiaoLing; Zhang, Qiang

doi:10.1007/s11694-022-01427-w

Cited by 8 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The solubility and stability of the substances can be significantly influenced by hydrogen bonds. Liu et al's research indicates that the strong hydrogen interaction between DESs and the solvent, which masks the phenolic hydroxyl groups and reduces the sturdiness of the structural elements consisting of the stacked rings of aromatic compounds, is the primary cause of the unique solubilization effect of DESs on phenolic compounds [37] . After conducting our analysis, DES-1 (Chl-Mali (1:1)) was selected as the extraction solvent for CGA in E. ulmoides .…”

Section: Resultsmentioning

confidence: 99%

An integrated process by ultrasonic enhancement in the deep eutectic solvents system for extraction and separation of chlorogenic acid from Eucommia ulmoides leaves

Meng,

Sui,

Pan

et al. 2023

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

An integrated process by ultrasonic enhancement in the deep eutectic solvents system for extraction and separation of chlorogenic acid from Eucommia ulmoides leaves

Meng,

Sui,

Pan

et al. 2023

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

“…There are pieces of evidence to suggest that active plant compounds like flavonoids and phenols may be more soluble in alcohol solutions. For instance, 60% ethanol extract from Eucommia ulmoides leaves had higher total phenol and flavonoid levels and a larger antioxidant potential when compared to water extract [ 36 ]. An earlier investigation found that antioxidants in tea prepared from Malus toringoides leaves are more likely to dissolve in medium-polarity organic solvents [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling

et al. 2022

View full text Add to dashboard Cite

Eucommia ulmoides Oliver staminate flower (ESF) tea enjoys a good reputation in folk medicine and displays multiple bioactivities, such as antioxidant and antifatigue properties. However, the underlying biological mechanisms remain largely unknown. In this study, we aimed to investigate whether ESF tea can mitigate cellular oxidative stress. Crude ethyl alcohol extract and its three subfractions prepared by sequential extraction with chloroform, n-butyl alcohol and residual water were prepared from ESF tea. The results of antioxidant activity tests in vitro manifested n-butyl alcohol fraction (n-BUF) showed the strongest antioxidant capacity (DPPH: IC50 = 24.45 ± 0.74 μg/mL, ABTS: IC50 = 17.25 ± 0.04 μg/mL). Moreover, all subfractions of ESF tea, especially the n-BUF, exhibited an obvious capacity to scavenge the reactive oxygen species (ROS) and stimulate the NRF2 antioxidative response in human keratinocytes HaCaT treated by H2O2. Using ultra-high-performance liquid chromatography, we identified geniposidic acid (GPA) as the most abundant component in ESF tea extract. Furthermore, it was found that GPA relieved oxidative stress in H2O2-induced HaCaT cells by activating the Akt/Nrf2/OGG1 pathway. Our findings indicated that ESF tea may be a source of natural antioxidants to protect against skin cell oxidative damage and deserves further development and utilization.

show abstract

“…In China, Eucommia ulmoides (E. ulmoides) has been employed as a traditional Chinese medicine for more than 2000 years [1][2][3]. It has a variety of biological activities including antioxidative [4,5], anti-hypertensive [6,7], anti-inflammatory [8,9], and anti-obesity [10,11] impacts to fortify the immune system and internal organs of humans. When considering the availability of resources, E. ulmoides leaves (EULs) have been regarded as a very useful option compared to E. ulmoides bark due to their rich resources and excellent ability to regenerate and recover [12].…”

Section: Introductionmentioning

confidence: 99%

Combination of a Deep Eutectic Solvent and Macroporous Resin for Green Recovery of Iridoids, Chlorogenic Acid, and Flavonoids from Eucommia ulmoides Leaves

Liao,

Chen,

Tang

et al. 2024

Molecules

View full text Add to dashboard Cite

To increase the effectiveness of using typical biomass waste as a resource, iridoids, chlorogenic acid, and flavonoids from the waste biomass of Eucommia ulmoides leaves (EULs) were extracted by deep eutectic solvents (DESs) in conjunction with macroporous resin. To optimize the extract conditions, the experiment of response surface was employed with the single-factor of DES composition molar ratio, liquid–solid ratio, water percentage, extraction temperature, and extraction time. The findings demonstrated that the theoretical simulated extraction yield of chlorogenic acid (CGA), geniposidic acid (GPA), aucubin (AU), geniposide (GP), rutin (RU), and isoquercetin (IQU) were 42.8, 137.2, 156.7, 5.4, 13.5, and 12.8 mg/g, respectively, under optimal conditions (hydrogen bond donor–hydrogen bond acceptor molar ratio of 1.96, liquid–solid ratio of 28.89 mL/g, water percentage of 38.44%, temperature of 317.36 K, and time of 55.59 min). Then, 12 resins were evaluated for their adsorption and desorption capabilities for the target components, and the HPD950 resin was found to operate at its optimum. Additionally, the HPD950 resin demonstrated significant sustainability and considerable potential in the recyclability test. Finally, the hypoglycemic in vitro, hypolipidemic in vitro, immunomodulatory, and anti-inflammatory effects of EUL extract were evaluated, and the correlation analysis of six active components with biological activity and physicochemical characteristics of DESs by heatmap were discussed. The findings of this study can offer a theoretical foundation for the extraction of valuable components by DESs from waste biomass, as well as specific utility benefits for the creation and development of natural products.

show abstract

Deep eutectic solvents in the extraction of active compounds from Eucommia Ulmoides Oliv. leaves

Cited by 8 publications

References 41 publications

An integrated process by ultrasonic enhancement in the deep eutectic solvents system for extraction and separation of chlorogenic acid from Eucommia ulmoides leaves

An integrated process by ultrasonic enhancement in the deep eutectic solvents system for extraction and separation of chlorogenic acid from Eucommia ulmoides leaves

Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling

Combination of a Deep Eutectic Solvent and Macroporous Resin for Green Recovery of Iridoids, Chlorogenic Acid, and Flavonoids from Eucommia ulmoides Leaves

Contact Info

Product

Resources

About