Deep Learning-Assisted Intelligent Artificial Vision Platform Based on Dual-Luminescence Eu(III)-Functionalized HOF for the Diagnosis of Breast and Ovarian Cancer

Hu, Zhongqian; Yan, Bing

doi:10.1021/acs.analchem.3c04624

Anal. Chem.

2023

DOI: 10.1021/acs.analchem.3c04624

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Deep Learning-Assisted Intelligent Artificial Vision Platform Based on Dual-Luminescence Eu(III)-Functionalized HOF for the Diagnosis of Breast and Ovarian Cancer

Zhongqian Hu,

Bing Yan

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Cited by 14 publications

References 48 publications

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Hydrogen‐Bonded Organic Frameworks as an Appealing Platform for Luminescent Sensing

Xiong,

Xiang,

et al. 2024

Adv Funct Materials

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Hydrogen‐bonded organic frameworks (HOFs), a novel subclass of porous crystalline materials self‐assembled from organic linkers through hydrogen bonding and other intermolecular interactions, have emerged as an exciting platform for developing multifunctional materials. Recently, luminescent HOF sensors have drawn considerable attention due to their unique advantages, such as hydrogen‐bonding flexibility, inherent luminescent centers in organic linkers, ease of functionalization, low density and toxicity, and good stability. However, a comprehensive study on the design strategies, functionalities, and applications of HOFs in sensing is lacking. In this review, the uniqueness and development of luminescent sensing HOFs are outlined. The design principles and strategies to enable the sensing performance are summarized, including the pre‐design of luminescent organic linkers and post‐modification with additional luminescent species. The state‐of‐the‐art advances in diverse sensing applications are overviewed, such as the detection of chemical pollutants, biomolecules, gases, and physical factors like temperature and mechanical forces. Moreover, the current challenges and corresponding potential avenues are discussed. This review aims to inspire more innovative research on the fabrication of advanced HOFs for luminescent sensing functions.

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Hydrogen‐Bonded Organic Frameworks as an Appealing Platform for Luminescent Sensing

Xiong,

Xiang,

et al. 2024

Adv Funct Materials

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Hydrogen‐Bonded Organic Framework Enhanced Antifouling Property for Efficient In Situ Electrochemical Assay of Cerebral Ascorbic Acid

Zheng,

Liu,

et al. 2024

Small

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Accurate determination of cerebral ascorbic acid (AA) is crucial for understanding ischemic stroke (IS) related pathological events. Carbon fiber microelectrodes (CFEs) have proven to be robust tools with high sensitivity toward AA, however, they face ongoing challenges for in situ measurement due to the non‐specific adsorption of proteins in brain tissue. In this study, the hydrogen‐bonded organic framework PFC‐71 is synthesized and modified on CFEs through π‐π stacking interactions with carboxylated carbon nanotubes (CNT‐COOH). It is found that the gating effect and hydrophilicity of PFC‐71 provided the CFE with excellent antibiofouling properties. As a result, AA exhibited a low oxidation potential of −30 mV on the CFE/CNT‐COOH/PFC‐71, even in the presence of 20 mg mL−1 bovine serum albumin. Given the structural advantages of CFE/CNT‐COOH/PFC‐71, a ratiometric electrochemical strategy for AA is established, enabling the in situ assay of cerebral AA in a middle cerebral artery occlusion (MCAO) model with high accuracy and stability.

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Dual-emission rare-earth fluorescent nanomaterials for ratiometric and visual detection of N-acetylneuraminic acid and applications in information encryption and anti-counterfeiting

Wei,

Gu,

et al. 2024

Analytica Chimica Acta

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Deep Learning-Assisted Intelligent Artificial Vision Platform Based on Dual-Luminescence Eu(III)-Functionalized HOF for the Diagnosis of Breast and Ovarian Cancer

Cited by 14 publications

References 48 publications

Hydrogen‐Bonded Organic Frameworks as an Appealing Platform for Luminescent Sensing

Hydrogen‐Bonded Organic Frameworks as an Appealing Platform for Luminescent Sensing

Hydrogen‐Bonded Organic Framework Enhanced Antifouling Property for Efficient In Situ Electrochemical Assay of Cerebral Ascorbic Acid

Dual-emission rare-earth fluorescent nanomaterials for ratiometric and visual detection of N-acetylneuraminic acid and applications in information encryption and anti-counterfeiting

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