Deep-penetration functionalized cuttlefish ink nanoparticles for combating wound infections with synergetic photothermal-immunologic therapy

Qu, Wenqiang; Fan, Jin‐Xuan; Zheng, Di‐Wei; Gu, Hui-Yun; Yu, Yifeng; Xiao, Yajun; Zhao, Kai; Hu, Zhidong; Qi, Baiwen; Zhang, Xian‐Zheng; Yu, Aixi

doi:10.1016/j.biomaterials.2023.122231

Cited by 18 publications

(5 citation statements)

References 41 publications

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“…In the case of bacterial infection, the immunosuppressive microenvironment will cause a switch of host infection-associated macrophages, from pro-inflammatory macrophages (M1) to anti-inflammatory macrophages (M2) in order to evade immunologic eradication. The M1-type macrophages could not only phagocyte and kill pathogenic bacteria directly, but also secret inflammatory factors to induce DCs maturation and thus reverse immune suppression [ 27 , 28 ]. As a result, repolarizing macrophages into M1 phenotype is considered as a promising therapeutic strategy for bacterial infection.…”

Section: Methodsmentioning

confidence: 99%

Nanotheranostic Trojan Horse for visualization and photo-immunotherapy of multidrug-resistant bacterial infection

Pang,

Xu,

Geng

et al. 2023

J Nanobiotechnol

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Effective diagnosis and therapy for bacterial infections, especially those caused by multidrug-resistant (MDR) species, greatly challenge current antimicrobial stewardship. Monocytes, which can chemotactically migrate from the blood to infection site and elicit a robust infection infiltration, provide a golden opportunity for bacterial theranostics. Here, a nano-Trojan Horse was facilely engineered using mannose-functionalized manganese-eumelanin coordination nanoparticles (denoted as MP-MENP) for precise two-step localization and potent photothermal-immunotherapy of MDR bacterial infection. Taking advantage of the selective recognition between mannose and inflammation-associated monocytes, the MP-MENP could be passively piggybacked to infection site by circulating monocytes, and also actively target infiltrated monocytes that are already accumulated in infection microenvironment. Such dual-pronged targeting enabled an efficient imaging diagnosis of bacterial infection. Upon laser irradiation, the MP-MENP robustly produced local hyperemia to ablate bacteria, both extracellularly and intracellularly. Further combined with photothermal therapy-induced immunogenic cell death and MP-MENP-mediated macrophage reprogramming, the immunosuppressive infection microenvironment was significantly relieved, allowing an enhanced antibacterial immunity. Collectively, the proposed nanotheranostic Trojan Horse, which integrates dual-pronged targeting, precise imaging diagnosis, and high-performance photothermal immunotherapy, promises a new way for complete eradication of MDR bacterial infection.

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Section: Methodsmentioning

confidence: 99%

Nanotheranostic Trojan Horse for visualization and photo-immunotherapy of multidrug-resistant bacterial infection

Pang,

Xu,

Geng

et al. 2023

J Nanobiotechnol

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“…Melanin nanoparticles derived from cuttlefish ink and hairs have good photothermal effects. 70 Due to the strong NIR absorption and high drug loading efficiency of PDA, Xu et al utilized PDA to prepare a AuNBs@ PDA/Dox system for PAI/CT guided chemical−photothermal synergistic treatment. 71 AuNBs@PDA/Dox has strong NIR absorption capacity and higher PCE than AuNBs alone, which is more conducive to PAI and PTT.…”

Section: Organic Polymer Photothermal Agentsmentioning

confidence: 99%

“…There are also natural polymers in nature that can be used for PTT. Melanin nanoparticles derived from cuttlefish ink and hairs have good photothermal effects …”

Section: Types Of Photothermal Agents Commonly Used In Pttmentioning

confidence: 99%

Advances of Photothermal Agents with Fluorescence Imaging/Enhancement Ability in the Field of Photothermal Therapy and Diagnosis

Yuan,

Zhou,

Wang

et al. 2024

Mol. Pharmaceutics

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Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct and accurate local treatment can be performed in a noninvasive manner by PTT. This treatment strategy requires the use of photothermal agents to convert light energy into heat energy, thereby achieving local heating and triggering biochemical processes to kill tumor cells. As a key factor in PTT, the photothermal conversion ability of photothermal agents directly determines the efficacy of PTT. In addition, photothermal agents generally have photothermal imaging (PTI) and photoacoustic imaging (PAI) functions, which can not only guide the optimization of irradiation conditions but also achieve the integration of disease diagnosis. If the photothermal agents have function of fluorescence imaging (FLI) or fluorescence enhancement, they can not only further improve the accuracy in disease diagnosis but also accurately determine the tumor location through multimodal imaging for corresponding treatment. In this paper, we summarize recent advances in photothermal agents with FLI or fluorescence enhancement functions for PTT and tumor diagnosis. According to the different recognition sites, the application of specific targeting photothermal agents is introduced. Finally, limitations and challenges of photothermal agents with fluorescence imaging/enhancement in the field of PTT and tumor diagnosis are prospected.

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“…In addition, an appreciable increase in stability and efficiency was observed, attributed to the spherical and well-dispersed shape of the nanoparticles [151]. Finally, PBCTPNs were compared with PLGA nanoparticles (PN) and mPEG-C18/TPGS/PLGA (PCTPN) nanoparticles, demonstrating that ICG fluorescence was Photothermal therapy is used to target localized tumors [144], treatments in ophthalmological diseases [145], bacterial and microbial infection [146], dermatological diseases [147], tissue repair [148], and the release of chemotherapeutic drugs [149] in a highly selective and minimally invasive manner, with short treatment times [150]. Ting et al demonstrated that hybrid polymer nanoparticles composed of methoxy polyethylene glycol-benzoic-imino-1-octadecanamine (mPEG-b-C18), hydrophobic poly(lactic-coglycolic acid) (PLGA), and polyethylene glycol tocopheryl succinate (TPGS), called PBCTPN, and carrying indocyanine green (ICG) (a photothermal agent of amphiphilic nature approved by the FDA), improved the aggregation, photostability, and release of ICG.…”

Section: Photothermal Therapymentioning

confidence: 99%

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

Barba-Rosado,

Carrascal-Hernández,

Insuasty

et al. 2024

Nanomaterials

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Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.

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Deep-penetration functionalized cuttlefish ink nanoparticles for combating wound infections with synergetic photothermal-immunologic therapy

Cited by 18 publications

References 41 publications

Nanotheranostic Trojan Horse for visualization and photo-immunotherapy of multidrug-resistant bacterial infection

Nanotheranostic Trojan Horse for visualization and photo-immunotherapy of multidrug-resistant bacterial infection

Advances of Photothermal Agents with Fluorescence Imaging/Enhancement Ability in the Field of Photothermal Therapy and Diagnosis

Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis

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